DISULFIDE COMPOUND

DISULFIDE COMPOUND

NEW MATERIAL:The compound of formula I (n is 1-5; R1 and R2 are H or R1 and R2 together form phthaloyl). EXAMPLE:5,5'-Dithiobis-3-oxapentylamine. USE:Useful as a synthetic raw material for medicines, especially the mitomycin derivative having antitumor activity and excellent water-solubility. P...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHIRAHATA KIMIKATSU, KASAI MASAJI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:NEW MATERIAL:The compound of formula I (n is 1-5; R1 and R2 are H or R1 and R2 together form phthaloyl). EXAMPLE:5,5'-Dithiobis-3-oxapentylamine. USE:Useful as a synthetic raw material for medicines, especially the mitomycin derivative having antitumor activity and excellent water-solubility. PREPARATION:The compound of formula I can be produced by dissolving the compound of formula II (X is halogen) in a mixture of water, methanol, etc., reacting with sodium thiosulfate at 50-80 deg.C, reacting the reaction product with iodine to obtain the compound of formula III, reacting the compound with hydrazine to eliminate the phthalimide group and if necessary, converting the product to a salt.