PRODUCTION OF RACEMIC TYPE N-ACYLPHENYLALANINE

PURPOSE:In heating N-acyl-D-phenylalanine, etc., as a raw material in an organic solvent, to obtain the titled compound useful as an essential component of a medicine for promoting nutrition, etc., by a simple operation in a short time, by carrying out the heating in the presence of a catalytic amou...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	MIYASHITA YASUO, OSAI YOSHIO, AYABE MITSUKUNI, IKEDA TETSUMI, SHIMIZUI TSUNEHIKO
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

container_end_page
container_issue
container_start_page
container_title
container_volume
creator	MIYASHITA YASUO OSAI YOSHIO AYABE MITSUKUNI IKEDA TETSUMI SHIMIZUI TSUNEHIKO
description	PURPOSE:In heating N-acyl-D-phenylalanine, etc., as a raw material in an organic solvent, to obtain the titled compound useful as an essential component of a medicine for promoting nutrition, etc., by a simple operation in a short time, by carrying out the heating in the presence of a catalytic amount of a dehydrating agent. CONSTITUTION:N-Acyl-D-phenylalanine or N-acyl-L-phenylalanine is heated in the presence of a catalytic amount of a dehydrating agent (especially preferably acetic anhydride) in an aromatic hydrocarbon (preferably xylene) at >=130 deg.C, to give the titled compound. In order to obtain the titled compound from a reaction system, for example, after the reaction is over, the reaction solution is cooled while stirring, fine crystal is formed and dispersed in the solvent, so it is filtered. The amount of the dehydrating agent used is preferably 1-10wt% (0.02-0.2mol) based on the raw material N-acyl-D-phenylalanine.
format	Patent
fullrecord	<record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JPS61165354A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JPS61165354A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JPS61165354A3</originalsourceid><addsrcrecordid>eNrjZNALCPJ3CXUO8fT3U_B3UwhydHb19XRWCIkMcFXw03V0jvQJ8HD1i_Rx9HH08_Rz5WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8V4BwWaGhmamxqYmjsbEqAEA9uMmKQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PRODUCTION OF RACEMIC TYPE N-ACYLPHENYLALANINE</title><source>esp@cenet</source><creator>MIYASHITA YASUO ; OSAI YOSHIO ; AYABE MITSUKUNI ; IKEDA TETSUMI ; SHIMIZUI TSUNEHIKO</creator><creatorcontrib>MIYASHITA YASUO ; OSAI YOSHIO ; AYABE MITSUKUNI ; IKEDA TETSUMI ; SHIMIZUI TSUNEHIKO</creatorcontrib><description>PURPOSE:In heating N-acyl-D-phenylalanine, etc., as a raw material in an organic solvent, to obtain the titled compound useful as an essential component of a medicine for promoting nutrition, etc., by a simple operation in a short time, by carrying out the heating in the presence of a catalytic amount of a dehydrating agent. CONSTITUTION:N-Acyl-D-phenylalanine or N-acyl-L-phenylalanine is heated in the presence of a catalytic amount of a dehydrating agent (especially preferably acetic anhydride) in an aromatic hydrocarbon (preferably xylene) at >=130 deg.C, to give the titled compound. In order to obtain the titled compound from a reaction system, for example, after the reaction is over, the reaction solution is cooled while stirring, fine crystal is formed and dispersed in the solvent, so it is filtered. The amount of the dehydrating agent used is preferably 1-10wt% (0.02-0.2mol) based on the raw material N-acyl-D-phenylalanine.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1986</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860726&DB=EPODOC&CC=JP&NR=S61165354A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19860726&DB=EPODOC&CC=JP&NR=S61165354A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MIYASHITA YASUO</creatorcontrib><creatorcontrib>OSAI YOSHIO</creatorcontrib><creatorcontrib>AYABE MITSUKUNI</creatorcontrib><creatorcontrib>IKEDA TETSUMI</creatorcontrib><creatorcontrib>SHIMIZUI TSUNEHIKO</creatorcontrib><title>PRODUCTION OF RACEMIC TYPE N-ACYLPHENYLALANINE</title><description>PURPOSE:In heating N-acyl-D-phenylalanine, etc., as a raw material in an organic solvent, to obtain the titled compound useful as an essential component of a medicine for promoting nutrition, etc., by a simple operation in a short time, by carrying out the heating in the presence of a catalytic amount of a dehydrating agent. CONSTITUTION:N-Acyl-D-phenylalanine or N-acyl-L-phenylalanine is heated in the presence of a catalytic amount of a dehydrating agent (especially preferably acetic anhydride) in an aromatic hydrocarbon (preferably xylene) at >=130 deg.C, to give the titled compound. In order to obtain the titled compound from a reaction system, for example, after the reaction is over, the reaction solution is cooled while stirring, fine crystal is formed and dispersed in the solvent, so it is filtered. The amount of the dehydrating agent used is preferably 1-10wt% (0.02-0.2mol) based on the raw material N-acyl-D-phenylalanine.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1986</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNALCPJ3CXUO8fT3U_B3UwhydHb19XRWCIkMcFXw03V0jvQJ8HD1i_Rx9HH08_Rz5WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8V4BwWaGhmamxqYmjsbEqAEA9uMmKQ</recordid><startdate>19860726</startdate><enddate>19860726</enddate><creator>MIYASHITA YASUO</creator><creator>OSAI YOSHIO</creator><creator>AYABE MITSUKUNI</creator><creator>IKEDA TETSUMI</creator><creator>SHIMIZUI TSUNEHIKO</creator><scope>EVB</scope></search><sort><creationdate>19860726</creationdate><title>PRODUCTION OF RACEMIC TYPE N-ACYLPHENYLALANINE</title><author>MIYASHITA YASUO ; OSAI YOSHIO ; AYABE MITSUKUNI ; IKEDA TETSUMI ; SHIMIZUI TSUNEHIKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS61165354A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1986</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>MIYASHITA YASUO</creatorcontrib><creatorcontrib>OSAI YOSHIO</creatorcontrib><creatorcontrib>AYABE MITSUKUNI</creatorcontrib><creatorcontrib>IKEDA TETSUMI</creatorcontrib><creatorcontrib>SHIMIZUI TSUNEHIKO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MIYASHITA YASUO</au><au>OSAI YOSHIO</au><au>AYABE MITSUKUNI</au><au>IKEDA TETSUMI</au><au>SHIMIZUI TSUNEHIKO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PRODUCTION OF RACEMIC TYPE N-ACYLPHENYLALANINE</title><date>1986-07-26</date><risdate>1986</risdate><abstract>PURPOSE:In heating N-acyl-D-phenylalanine, etc., as a raw material in an organic solvent, to obtain the titled compound useful as an essential component of a medicine for promoting nutrition, etc., by a simple operation in a short time, by carrying out the heating in the presence of a catalytic amount of a dehydrating agent. CONSTITUTION:N-Acyl-D-phenylalanine or N-acyl-L-phenylalanine is heated in the presence of a catalytic amount of a dehydrating agent (especially preferably acetic anhydride) in an aromatic hydrocarbon (preferably xylene) at >=130 deg.C, to give the titled compound. In order to obtain the titled compound from a reaction system, for example, after the reaction is over, the reaction solution is cooled while stirring, fine crystal is formed and dispersed in the solvent, so it is filtered. The amount of the dehydrating agent used is preferably 1-10wt% (0.02-0.2mol) based on the raw material N-acyl-D-phenylalanine.</abstract><oa>free_for_read</oa></addata></record>
fulltext	fulltext_linktorsrc
identifier
ispartof
issn
language	eng
recordid	cdi_epo_espacenet_JPS61165354A
source	esp@cenet
subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY
title	PRODUCTION OF RACEMIC TYPE N-ACYLPHENYLALANINE
url	https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-06T10%3A57%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MIYASHITA%20YASUO&rft.date=1986-07-26&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EJPS61165354A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true