DIBENZO(B,E)OXEPIN DERIVATIVE AND ANTIALLERGIC AGENT CONTAINING SAID DERIVATIVE AS ACTIVE COMPONENT

NEW MATERIAL:The dibenzo[b,e]oxepin derivative of formula I {R1 is cyano, 5-tetrazolyl, carbamoyl or -CO2R3 [R3 is H, alkyl or 1-(ethoxycarbonyloxy)ethyl]; R2 is 4-alkylpiperazino, 3-quinuclidylamino or -X-(CH2)n-NR4R5 (X is -NH, S or O; R4 and R5 are alkyl; n is 2 or 3)}, its acid addition salt or...

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Hauptverfasser:	OOMORI TAKEMORI, SHIYUTOU KATSUICHI, TAKIZAWA HIROSHI, IKUJI YOSHIMASA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	OOMORI TAKEMORI SHIYUTOU KATSUICHI TAKIZAWA HIROSHI IKUJI YOSHIMASA
description	NEW MATERIAL:The dibenzo[b,e]oxepin derivative of formula I {R1 is cyano, 5-tetrazolyl, carbamoyl or -CO2R3 [R3 is H, alkyl or 1-(ethoxycarbonyloxy)ethyl]; R2 is 4-alkylpiperazino, 3-quinuclidylamino or -X-(CH2)n-NR4R5 (X is -NH, S or O; R4 and R5 are alkyl; n is 2 or 3)}, its acid addition salt or metallic salt. EXAMPLE:11-(4-Methylpiperazino)-6,11-dihydrodibenzo[ b,e ]oxepin-2-carboxylic acid ethyl ester. USE:It has antiallergic activity and is useful as a remedy for asthma, etc. as an antiallergic agent. It is administered preferably by oral administration or injection. PREPARATION:The compound of formula I is prepared from the o-halomethylbenzoic acid of formula II and the alkali metal salt of formula III via various reaction steps.
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EXAMPLE:11-(4-Methylpiperazino)-6,11-dihydrodibenzo[ b,e ]oxepin-2-carboxylic acid ethyl ester. USE:It has antiallergic activity and is useful as a remedy for asthma, etc. as an antiallergic agent. It is administered preferably by oral administration or injection. 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EXAMPLE:11-(4-Methylpiperazino)-6,11-dihydrodibenzo[ b,e ]oxepin-2-carboxylic acid ethyl ester. USE:It has antiallergic activity and is useful as a remedy for asthma, etc. as an antiallergic agent. It is administered preferably by oral administration or injection. PREPARATION:The compound of formula I is prepared from the o-halomethylbenzoic acid of formula II and the alkali metal salt of formula III via various reaction steps.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	DIBENZO(B,E)OXEPIN DERIVATIVE AND ANTIALLERGIC AGENT CONTAINING SAID DERIVATIVE AS ACTIVE COMPONENT
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