PREPARATION OF DISPERSION OF PULMONARY SURFACE ACTIVE SUBSTANCE
PURPOSE:To prepare the titled dispersion without deteriorating the surface activity, by agitating a dispersion obtained by dispersing a pulmonary surface active substance in water or an electrolytic solution under warming. CONSTITUTION:A pulmonary surface active substance is dispersed in water or an...
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| creator | KOBAYASHI TSUTOMU YOSHIDA TSUNEMASA KOKUBO MASAYUKI |
| description | PURPOSE:To prepare the titled dispersion without deteriorating the surface activity, by agitating a dispersion obtained by dispersing a pulmonary surface active substance in water or an electrolytic solution under warming. CONSTITUTION:A pulmonary surface active substance is dispersed in water or an electrolytic solution containing sodium ion, potassium ion or magnesium ion, preferably in 0.05-10wt% dispersion concentration. The resultant dispersion is then agitated under warming, preferably at 30-100 deg.C warming temperature, to give the aimed dispersion. The pulmonary surface active substance contains dipalmitoyllecithin which is a phospholipid as a main constituent and is said to have a specific surface activity of changing the surface tension on the inner surface of air cells at expiration and inspiration and exhibit the anti-atelectatic action. The surface activity can be improved easily by the above-mentioned warming treatment. |
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CONSTITUTION:A pulmonary surface active substance is dispersed in water or an electrolytic solution containing sodium ion, potassium ion or magnesium ion, preferably in 0.05-10wt% dispersion concentration. The resultant dispersion is then agitated under warming, preferably at 30-100 deg.C warming temperature, to give the aimed dispersion. The pulmonary surface active substance contains dipalmitoyllecithin which is a phospholipid as a main constituent and is said to have a specific surface activity of changing the surface tension on the inner surface of air cells at expiration and inspiration and exhibit the anti-atelectatic action. The surface activity can be improved easily by the above-mentioned warming treatment.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PREPARATION OF DISPERSION OF PULMONARY SURFACE ACTIVE SUBSTANCE |
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