NOVEL METHOD FOR PREPARING O-DIFLUOROBENZENE

NOVEL METHOD FOR PREPARING O-DIFLUOROBENZENE

PURPOSE:To prepare the titled compound useful as a synthetic intermediate for antimicrobial agents in high yield, by adding a small amount of a silicone oil to 2-fluoro-1-benzenediazonium tetrafluoroborate in the thermal decomposition thereof. CONSTITUTION:o-Fluoroaniline is diazotized and then reac...

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Hauptverfasser: INAKA YUTAKA, OOTSUBO JIYUNICHIROU, KANOU MASANOBU
Format: Patent
Sprache:eng
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator INAKA YUTAKA
OOTSUBO JIYUNICHIROU
KANOU MASANOBU
description PURPOSE:To prepare the titled compound useful as a synthetic intermediate for antimicrobial agents in high yield, by adding a small amount of a silicone oil to 2-fluoro-1-benzenediazonium tetrafluoroborate in the thermal decomposition thereof. CONSTITUTION:o-Fluoroaniline is diazotized and then reacted with a fluoronating agent, e.g. borofluoric acid to give 2-fluoro-1-benzenediazonium tetrafluoroborate. A small amount, preferably about 4-5wt% based on the above-mentioned raw material, of a silicone oil is added to the 2-fluoro-1-benzenediazonium tetrafluoroborate and decomposed thermally under heating at 100- 180 deg.C, preferably 130-160 deg.C, for about 1-5hr to afford the aimed o-difluorobenzene. EFFECT:The reaction proceeds very mildly, and a reaction vessel of relatively small volume is enough.
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CONSTITUTION:o-Fluoroaniline is diazotized and then reacted with a fluoronating agent, e.g. borofluoric acid to give 2-fluoro-1-benzenediazonium tetrafluoroborate. A small amount, preferably about 4-5wt% based on the above-mentioned raw material, of a silicone oil is added to the 2-fluoro-1-benzenediazonium tetrafluoroborate and decomposed thermally under heating at 100- 180 deg.C, preferably 130-160 deg.C, for about 1-5hr to afford the aimed o-difluorobenzene. EFFECT:The reaction proceeds very mildly, and a reaction vessel of relatively small volume is enough.</abstract><oa>free_for_read</oa></addata></record>
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title NOVEL METHOD FOR PREPARING O-DIFLUOROBENZENE
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