NOVEL PREPARATION OF ANTIBIOTIC NEOVIRIDOGRISEINS

PURPOSE:To prepare antibiotic neoviridogriseins, especially neoviridogrisein IIselectively, by cultivating a bacterium belonging to the genus Streptomyces. CONSTITUTION:A variant such as Streptomyces sp.G-89 (FERM-P 184) belonging to the genus Streptomyces, capable of producing antibiotic neoviridog...

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Hauptverfasser:	OONISHI MASAHIRO, OKAMOTO ROKUROU, OKUMURA YASUSHI, NAGATO NOBUO, ISHIKURA TOMOYUKI
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	PURPOSE:To prepare antibiotic neoviridogriseins, especially neoviridogrisein IIselectively, by cultivating a bacterium belonging to the genus Streptomyces. CONSTITUTION:A variant such as Streptomyces sp.G-89 (FERM-P 184) belonging to the genus Streptomyces, capable of producing antibiotic neoviridogriseins shown by the formula (R is hydrogen, or hydroxyl group), deficient in prolylhydroxylase activity, is inoculated into a nutrient medium, cultivated at 24- 33 deg.C at 6-9pH under aerobic conditions, and antibiotic neoviridog riseins consisting essentially of antibiotic neoviridogrisein II wherein R is hydrogen atom in the formula is collected from the culture solution.