PREPARATION OF SYNTHETIC INTERMEDIATE OF METHANOCYCLINE
PURPOSE:To prepare the titled substance useful as a synthetic intermediate of pharmaceuticals, in high yield, by protecting the hydroxyl group of a specific compound, e.g. (1S, 2R, 3R, 5R)-2-carboxy-3-hydroxy-7,7-ethylenedioxy-bicyclo [3,3,0]octane, and reducing the protected compound. CONSTITUTION:...
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| creator | AMAMIYA SHIGEO KOJIMA KOUICHI |
| description | PURPOSE:To prepare the titled substance useful as a synthetic intermediate of pharmaceuticals, in high yield, by protecting the hydroxyl group of a specific compound, e.g. (1S, 2R, 3R, 5R)-2-carboxy-3-hydroxy-7,7-ethylenedioxy-bicyclo [3,3,0]octane, and reducing the protected compound. CONSTITUTION:The compound of formula I (Z is protecting group of carbonyl group), e.g. (1S,2R,3R,5R)-2-carboxy-3-hydroxy-7,7-ethylenedioxy-bicyclo[3,3,0] octane, is made to react with excessive reagent for forming a protective group of the hydroxyl group in the presence of a solvent. The resultant compound of formula II (R is OH-protecting group; R is same as R or H) is made to react with a reducing agent such as lithium aluminum hydride in the presence of a solvent at about room temperature to obtain the compound of formula III which is useful as a synthetic intermediate of methanocycline derivative having strong blood platelet coagulation inhibiting action. |
| format | Patent |
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CONSTITUTION:The compound of formula I (Z is protecting group of carbonyl group), e.g. (1S,2R,3R,5R)-2-carboxy-3-hydroxy-7,7-ethylenedioxy-bicyclo[3,3,0] octane, is made to react with excessive reagent for forming a protective group of the hydroxyl group in the presence of a solvent. The resultant compound of formula II (R is OH-protecting group; R is same as R or H) is made to react with a reducing agent such as lithium aluminum hydride in the presence of a solvent at about room temperature to obtain the compound of formula III which is useful as a synthetic intermediate of methanocycline derivative having strong blood platelet coagulation inhibiting action.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS ; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC ; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY ; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS ; TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</subject><creationdate>1984</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840220&DB=EPODOC&CC=JP&NR=S5931773A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25553,76306</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840220&DB=EPODOC&CC=JP&NR=S5931773A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AMAMIYA SHIGEO</creatorcontrib><creatorcontrib>KOJIMA KOUICHI</creatorcontrib><title>PREPARATION OF SYNTHETIC INTERMEDIATE OF METHANOCYCLINE</title><description>PURPOSE:To prepare the titled substance useful as a synthetic intermediate of pharmaceuticals, in high yield, by protecting the hydroxyl group of a specific compound, e.g. (1S, 2R, 3R, 5R)-2-carboxy-3-hydroxy-7,7-ethylenedioxy-bicyclo [3,3,0]octane, and reducing the protected compound. CONSTITUTION:The compound of formula I (Z is protecting group of carbonyl group), e.g. (1S,2R,3R,5R)-2-carboxy-3-hydroxy-7,7-ethylenedioxy-bicyclo[3,3,0] octane, is made to react with excessive reagent for forming a protective group of the hydroxyl group in the presence of a solvent. The resultant compound of formula II (R is OH-protecting group; R is same as R or H) is made to react with a reducing agent such as lithium aluminum hydride in the presence of a solvent at about room temperature to obtain the compound of formula III which is useful as a synthetic intermediate of methanocycline derivative having strong blood platelet coagulation inhibiting action.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS</subject><subject>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</subject><subject>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</subject><subject>TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1984</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDAPCHINcAxyDPH091Pwd1MIjvQL8XAN8XRW8PQLcQ3ydXXxdAxxBcn4uoZ4OPr5O0c6-3j6ufIwsKYl5hSn8kJpbgYFN9cQZw_d1IL8-NTigsTk1LzUknivgGBTS2NDc3NjR2MilAAAGrcocg</recordid><startdate>19840220</startdate><enddate>19840220</enddate><creator>AMAMIYA SHIGEO</creator><creator>KOJIMA KOUICHI</creator><scope>EVB</scope></search><sort><creationdate>19840220</creationdate><title>PREPARATION OF SYNTHETIC INTERMEDIATE OF METHANOCYCLINE</title><author>AMAMIYA SHIGEO ; KOJIMA KOUICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS5931773A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1984</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS</topic><topic>GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC</topic><topic>GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS</topic><topic>TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE</topic><toplevel>online_resources</toplevel><creatorcontrib>AMAMIYA SHIGEO</creatorcontrib><creatorcontrib>KOJIMA KOUICHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>AMAMIYA SHIGEO</au><au>KOJIMA KOUICHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PREPARATION OF SYNTHETIC INTERMEDIATE OF METHANOCYCLINE</title><date>1984-02-20</date><risdate>1984</risdate><abstract>PURPOSE:To prepare the titled substance useful as a synthetic intermediate of pharmaceuticals, in high yield, by protecting the hydroxyl group of a specific compound, e.g. (1S, 2R, 3R, 5R)-2-carboxy-3-hydroxy-7,7-ethylenedioxy-bicyclo [3,3,0]octane, and reducing the protected compound. CONSTITUTION:The compound of formula I (Z is protecting group of carbonyl group), e.g. (1S,2R,3R,5R)-2-carboxy-3-hydroxy-7,7-ethylenedioxy-bicyclo[3,3,0] octane, is made to react with excessive reagent for forming a protective group of the hydroxyl group in the presence of a solvent. The resultant compound of formula II (R is OH-protecting group; R is same as R or H) is made to react with a reducing agent such as lithium aluminum hydride in the presence of a solvent at about room temperature to obtain the compound of formula III which is useful as a synthetic intermediate of methanocycline derivative having strong blood platelet coagulation inhibiting action.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE |
| title | PREPARATION OF SYNTHETIC INTERMEDIATE OF METHANOCYCLINE |
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