MANUFACTURE OF CEPHALOSPORIN DERIVATIVE
A process for the manufacture of a cephalosporin derivative of the formula I: in which X is sulphur, oxygen or sulphinyl; R is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R is hydrogen or 1-6C alkyl; R is hydrogen or 1-6C alkyl; and the pharmaceutical...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | FUREDERIKU HENRI YUNGU FURANKU ROFUTASU ANII ANTOWANETSUTO ORIBUIE |
| description | A process for the manufacture of a cephalosporin derivative of the formula I: in which X is sulphur, oxygen or sulphinyl; R is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R is hydrogen or 1-6C alkyl; R is hydrogen or 1-6C alkyl; and the pharmaceutically-acceptable acid-addition and base-addition salts thereof, characterised by cyclisation of a compound of the formula II: or a derivative thereof in which the carbonyl group is masked, or an acid-addition salt thereof, in which R and R individually have one of the values for R and R , R is a nitrogen-protecting group and R is hydrogen or any one of the cephalosporin 3-carboxylic acid protecting groups known in the art; whereafter when the product from the cyclisation reatains the protecting group R (when R is other than hydrogen) the protecting group R is replaced by hydrogen by conventional means; and whereafter when the compound of the formula I is obtained in the form of the free base or salt, and a pharmaceutically-acceptable salt or free base respectively is required, any necessary conversion between free base and salt is carried out by conventional means. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JPS59122492A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JPS59122492A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JPS59122492A3</originalsourceid><addsrcrecordid>eNrjZFD3dfQLdXN0DgkNclXwd1Nwdg3wcPTxDw7wD_L0U3BxDfIMcwzxDHPlYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxXgHBppaGRkYmlkaOxsSoAQAGESRk</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>MANUFACTURE OF CEPHALOSPORIN DERIVATIVE</title><source>esp@cenet</source><creator>FUREDERIKU HENRI YUNGU ; FURANKU ROFUTASU ; ANII ANTOWANETSUTO ORIBUIE</creator><creatorcontrib>FUREDERIKU HENRI YUNGU ; FURANKU ROFUTASU ; ANII ANTOWANETSUTO ORIBUIE</creatorcontrib><description>A process for the manufacture of a cephalosporin derivative of the formula I: in which X is sulphur, oxygen or sulphinyl; R is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R is hydrogen or 1-6C alkyl; R is hydrogen or 1-6C alkyl; and the pharmaceutically-acceptable acid-addition and base-addition salts thereof, characterised by cyclisation of a compound of the formula II: or a derivative thereof in which the carbonyl group is masked, or an acid-addition salt thereof, in which R and R individually have one of the values for R and R , R is a nitrogen-protecting group and R is hydrogen or any one of the cephalosporin 3-carboxylic acid protecting groups known in the art; whereafter when the product from the cyclisation reatains the protecting group R (when R is other than hydrogen) the protecting group R is replaced by hydrogen by conventional means; and whereafter when the compound of the formula I is obtained in the form of the free base or salt, and a pharmaceutically-acceptable salt or free base respectively is required, any necessary conversion between free base and salt is carried out by conventional means.</description><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1984</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840714&DB=EPODOC&CC=JP&NR=S59122492A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19840714&DB=EPODOC&CC=JP&NR=S59122492A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FUREDERIKU HENRI YUNGU</creatorcontrib><creatorcontrib>FURANKU ROFUTASU</creatorcontrib><creatorcontrib>ANII ANTOWANETSUTO ORIBUIE</creatorcontrib><title>MANUFACTURE OF CEPHALOSPORIN DERIVATIVE</title><description>A process for the manufacture of a cephalosporin derivative of the formula I: in which X is sulphur, oxygen or sulphinyl; R is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R is hydrogen or 1-6C alkyl; R is hydrogen or 1-6C alkyl; and the pharmaceutically-acceptable acid-addition and base-addition salts thereof, characterised by cyclisation of a compound of the formula II: or a derivative thereof in which the carbonyl group is masked, or an acid-addition salt thereof, in which R and R individually have one of the values for R and R , R is a nitrogen-protecting group and R is hydrogen or any one of the cephalosporin 3-carboxylic acid protecting groups known in the art; whereafter when the product from the cyclisation reatains the protecting group R (when R is other than hydrogen) the protecting group R is replaced by hydrogen by conventional means; and whereafter when the compound of the formula I is obtained in the form of the free base or salt, and a pharmaceutically-acceptable salt or free base respectively is required, any necessary conversion between free base and salt is carried out by conventional means.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1984</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD3dfQLdXN0DgkNclXwd1Nwdg3wcPTxDw7wD_L0U3BxDfIMcwzxDHPlYWBNS8wpTuWF0twMim6uIc4euqkF-fGpxQWJyal5qSXxXgHBppaGRkYmlkaOxsSoAQAGESRk</recordid><startdate>19840714</startdate><enddate>19840714</enddate><creator>FUREDERIKU HENRI YUNGU</creator><creator>FURANKU ROFUTASU</creator><creator>ANII ANTOWANETSUTO ORIBUIE</creator><scope>EVB</scope></search><sort><creationdate>19840714</creationdate><title>MANUFACTURE OF CEPHALOSPORIN DERIVATIVE</title><author>FUREDERIKU HENRI YUNGU ; FURANKU ROFUTASU ; ANII ANTOWANETSUTO ORIBUIE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS59122492A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1984</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>FUREDERIKU HENRI YUNGU</creatorcontrib><creatorcontrib>FURANKU ROFUTASU</creatorcontrib><creatorcontrib>ANII ANTOWANETSUTO ORIBUIE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FUREDERIKU HENRI YUNGU</au><au>FURANKU ROFUTASU</au><au>ANII ANTOWANETSUTO ORIBUIE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>MANUFACTURE OF CEPHALOSPORIN DERIVATIVE</title><date>1984-07-14</date><risdate>1984</risdate><abstract>A process for the manufacture of a cephalosporin derivative of the formula I: in which X is sulphur, oxygen or sulphinyl; R is any one of the C-3 substituents from antibacterially-active cephalosporins known in the art; R is hydrogen or 1-6C alkyl; R is hydrogen or 1-6C alkyl; and the pharmaceutically-acceptable acid-addition and base-addition salts thereof, characterised by cyclisation of a compound of the formula II: or a derivative thereof in which the carbonyl group is masked, or an acid-addition salt thereof, in which R and R individually have one of the values for R and R , R is a nitrogen-protecting group and R is hydrogen or any one of the cephalosporin 3-carboxylic acid protecting groups known in the art; whereafter when the product from the cyclisation reatains the protecting group R (when R is other than hydrogen) the protecting group R is replaced by hydrogen by conventional means; and whereafter when the compound of the formula I is obtained in the form of the free base or salt, and a pharmaceutically-acceptable salt or free base respectively is required, any necessary conversion between free base and salt is carried out by conventional means.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_JPS59122492A |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | MANUFACTURE OF CEPHALOSPORIN DERIVATIVE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-12T02%3A25%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=FUREDERIKU%20HENRI%20YUNGU&rft.date=1984-07-14&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EJPS59122492A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |