HYDRAZINOPYRIDAZINE DERIVATIVE

NEW MATERIAL:A compound of formula I [R1 is H, CN, halogen, alkyl, ethynyl, etc.; R2 is H, CN, alkoxyl, (substituted) alkyl, etc.; R3 is H, alkoxyl, etc.; R4 is H or alkyl; R5 is R4 or halogen; R6 and R7 are R4; Z is O, NR8 (R8 is H or alkyl), NHCO, etc.; Y is NH2, formula VIII; n is 1 or 2] and a s...

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Bibliographische Detailangaben
Hauptverfasser:	TANIMOTO YOSHITAKA, IZUMI AKIHIRO, OOUCHI RIKIO, YASUDA KIKUO, TAKEZAKI TAKAYUKI, HIMORI NORIO, ISHIMORI TSUTOMU, SEKI TOSHIMI, YAMAGUCHI TAKASHI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:A compound of formula I [R1 is H, CN, halogen, alkyl, ethynyl, etc.; R2 is H, CN, alkoxyl, (substituted) alkyl, etc.; R3 is H, alkoxyl, etc.; R4 is H or alkyl; R5 is R4 or halogen; R6 and R7 are R4; Z is O, NR8 (R8 is H or alkyl), NHCO, etc.; Y is NH2, formula VIII; n is 1 or 2] and a salt thereof. EXAMPLE:1-( 2-Ethynylphenoxy )-3-[1,1-dimethyl-2-( 3-hydrazino-6-pyridazinyloxy ) ethylamino]-2-propanol. USE:A hypotensive agent having improved vasodilator action and mostly improved beta-blocking action. PROCESS:A compound of formula II obtained from a compound expressed by formula III as a starting material according to the reaction formulas is reacted with hydrazine or hydrate thereof to give the compound of formula I in which Z is O. A compound of formula V is a novel substance.