HYPOTENSOR

PURPOSE:The titled drug that contains omega-piperazinylalkoxy)-alkylenedioxybenzene as an active ingredient, thus developing hypotensive action rapidly and keeping it for hours with high safety. CONSTITUTION:The objective drug contains omega-piperazinylalkoxy)-alkylenedioxybenzene of formula I (m is...

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Hauptverfasser:	KIKUMOTO RIYOUJI, IKOMA EISHIN, SUGANO MAMORU, SHIMAZAKI SHIGEKI, NAKAO KENICHIROU, FUKAMI JIICHI
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	KIKUMOTO RIYOUJI IKOMA EISHIN SUGANO MAMORU SHIMAZAKI SHIGEKI NAKAO KENICHIROU FUKAMI JIICHI
description	PURPOSE:The titled drug that contains omega-piperazinylalkoxy)-alkylenedioxybenzene as an active ingredient, thus developing hypotensive action rapidly and keeping it for hours with high safety. CONSTITUTION:The objective drug contains omega-piperazinylalkoxy)-alkylenedioxybenzene of formula I (m is 1-3; n is 2-10; the group of formula II is phenyl which may be sustituted with halogen, trifluoromethyl, alkoxy, or alkylcarbonyl) or its acid adduct as an active ingredient. The compound of formula I is obtained by reaction between a halogenoalkoxyalkylenedioxybenzene of formula III(X is halogen) and a piperazine of formula IV in the presence or absence of an inert solvent such as THF at room temperature to 150 deg.C. The compound of formula I rapidly develops hypotensive action sufficiently even on oral administration, further, showing weak acute toxicity. The safety of the drug is very high considering its threshold value.
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CONSTITUTION:The objective drug contains omega-piperazinylalkoxy)-alkylenedioxybenzene of formula I (m is 1-3; n is 2-10; the group of formula II is phenyl which may be sustituted with halogen, trifluoromethyl, alkoxy, or alkylcarbonyl) or its acid adduct as an active ingredient. The compound of formula I is obtained by reaction between a halogenoalkoxyalkylenedioxybenzene of formula III(X is halogen) and a piperazine of formula IV in the presence or absence of an inert solvent such as THF at room temperature to 150 deg.C. The compound of formula I rapidly develops hypotensive action sufficiently even on oral administration, further, showing weak acute toxicity. The safety of the drug is very high considering its threshold value.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1983</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19831110&DB=EPODOC&CC=JP&NR=S58192824A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25555,76308</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19831110&DB=EPODOC&CC=JP&NR=S58192824A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KIKUMOTO RIYOUJI</creatorcontrib><creatorcontrib>IKOMA EISHIN</creatorcontrib><creatorcontrib>SUGANO MAMORU</creatorcontrib><creatorcontrib>SHIMAZAKI SHIGEKI</creatorcontrib><creatorcontrib>NAKAO KENICHIROU</creatorcontrib><creatorcontrib>FUKAMI JIICHI</creatorcontrib><title>HYPOTENSOR</title><description>PURPOSE:The titled drug that contains omega-piperazinylalkoxy)-alkylenedioxybenzene as an active ingredient, thus developing hypotensive action rapidly and keeping it for hours with high safety. 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The safety of the drug is very high considering its threshold value.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1983</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZODyiAzwD3H1C_YP4mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8V4BwaYWhpZGFkYmjsbEqAEAeMsccg</recordid><startdate>19831110</startdate><enddate>19831110</enddate><creator>KIKUMOTO RIYOUJI</creator><creator>IKOMA EISHIN</creator><creator>SUGANO MAMORU</creator><creator>SHIMAZAKI SHIGEKI</creator><creator>NAKAO KENICHIROU</creator><creator>FUKAMI JIICHI</creator><scope>EVB</scope></search><sort><creationdate>19831110</creationdate><title>HYPOTENSOR</title><author>KIKUMOTO RIYOUJI ; IKOMA EISHIN ; SUGANO MAMORU ; SHIMAZAKI SHIGEKI ; NAKAO KENICHIROU ; FUKAMI JIICHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS58192824A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1983</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KIKUMOTO RIYOUJI</creatorcontrib><creatorcontrib>IKOMA EISHIN</creatorcontrib><creatorcontrib>SUGANO MAMORU</creatorcontrib><creatorcontrib>SHIMAZAKI SHIGEKI</creatorcontrib><creatorcontrib>NAKAO KENICHIROU</creatorcontrib><creatorcontrib>FUKAMI JIICHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KIKUMOTO RIYOUJI</au><au>IKOMA EISHIN</au><au>SUGANO MAMORU</au><au>SHIMAZAKI SHIGEKI</au><au>NAKAO KENICHIROU</au><au>FUKAMI JIICHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HYPOTENSOR</title><date>1983-11-10</date><risdate>1983</risdate><abstract>PURPOSE:The titled drug that contains omega-piperazinylalkoxy)-alkylenedioxybenzene as an active ingredient, thus developing hypotensive action rapidly and keeping it for hours with high safety. CONSTITUTION:The objective drug contains omega-piperazinylalkoxy)-alkylenedioxybenzene of formula I (m is 1-3; n is 2-10; the group of formula II is phenyl which may be sustituted with halogen, trifluoromethyl, alkoxy, or alkylcarbonyl) or its acid adduct as an active ingredient. The compound of formula I is obtained by reaction between a halogenoalkoxyalkylenedioxybenzene of formula III(X is halogen) and a piperazine of formula IV in the presence or absence of an inert solvent such as THF at room temperature to 150 deg.C. The compound of formula I rapidly develops hypotensive action sufficiently even on oral administration, further, showing weak acute toxicity. The safety of the drug is very high considering its threshold value.</abstract><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	HYPOTENSOR
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