PREPARATION OF DRUG HAVING ENTERIC COATING
PURPOSE:To prepare the titled drug without using an organic solvent, by using a solution obtained by dissolving an enteric cellulose derivative in an alkaline aqueous solution, and adding a carboxylic acid to the solution. CONSTITUTION:An enteric cellulose derivative such as hydroxypropyl methyl cel...
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| creator | NAGURA SHIGEHIRO MARUYAMA KAZUMASA MINEMURA KATSUYOSHI MUTOU YASUAKI CHIBA TOORU |
| description | PURPOSE:To prepare the titled drug without using an organic solvent, by using a solution obtained by dissolving an enteric cellulose derivative in an alkaline aqueous solution, and adding a carboxylic acid to the solution. CONSTITUTION:An enteric cellulose derivative such as hydroxypropyl methyl cellulose phthalate, carboxymethyl ethyl cellulose, etc. is dissolved in an alkaline aqueous solution (the alkali is e.g. alkali metal hydroxide or carbonate, or ammonia), a carboxylic acid is added to the solution in an amount of >=50%, preferably >=60% equivalent of the alkali, and the resultant solution is applied to a solid drug such as tablet, capsule, etc. by conventional method. To prevent the precipitation of large gelatinous lumps, the carboxylic acid is diluted with water (usually to a concentration of |
| format | Patent |
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CONSTITUTION:An enteric cellulose derivative such as hydroxypropyl methyl cellulose phthalate, carboxymethyl ethyl cellulose, etc. is dissolved in an alkaline aqueous solution (the alkali is e.g. alkali metal hydroxide or carbonate, or ammonia), a carboxylic acid is added to the solution in an amount of >=50%, preferably >=60% equivalent of the alkali, and the resultant solution is applied to a solid drug such as tablet, capsule, etc. by conventional method. To prevent the precipitation of large gelatinous lumps, the carboxylic acid is diluted with water (usually to a concentration of <=5wt%) and added slowly to the solution under vigorous agitation. 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EFFECT:The problems inevitable to organic solvents, e.g. hazards of fire and explosion, pollution of working, environment residual solvent in the coating layer, etc. can be solved.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1983</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNAKCHINcAxyDPH091Pwd1NwCQp1V_BwDPP0c1dw9QtxDfJ0VnD2B0r7ufMwsKYl5hSn8kJpbgZFN9cQZw_d1IL8-NTigsTk1LzUknivgGBTC0NjUwsDc0djYtQAAFKkJOs</recordid><startdate>19830812</startdate><enddate>19830812</enddate><creator>NAGURA SHIGEHIRO</creator><creator>MARUYAMA KAZUMASA</creator><creator>MINEMURA KATSUYOSHI</creator><creator>MUTOU YASUAKI</creator><creator>CHIBA TOORU</creator><scope>EVB</scope></search><sort><creationdate>19830812</creationdate><title>PREPARATION OF DRUG HAVING ENTERIC COATING</title><author>NAGURA SHIGEHIRO ; MARUYAMA KAZUMASA ; MINEMURA KATSUYOSHI ; MUTOU YASUAKI ; CHIBA TOORU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPS58135807A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1983</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>NAGURA SHIGEHIRO</creatorcontrib><creatorcontrib>MARUYAMA KAZUMASA</creatorcontrib><creatorcontrib>MINEMURA KATSUYOSHI</creatorcontrib><creatorcontrib>MUTOU YASUAKI</creatorcontrib><creatorcontrib>CHIBA TOORU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NAGURA SHIGEHIRO</au><au>MARUYAMA KAZUMASA</au><au>MINEMURA KATSUYOSHI</au><au>MUTOU YASUAKI</au><au>CHIBA TOORU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PREPARATION OF DRUG HAVING ENTERIC COATING</title><date>1983-08-12</date><risdate>1983</risdate><abstract>PURPOSE:To prepare the titled drug without using an organic solvent, by using a solution obtained by dissolving an enteric cellulose derivative in an alkaline aqueous solution, and adding a carboxylic acid to the solution. CONSTITUTION:An enteric cellulose derivative such as hydroxypropyl methyl cellulose phthalate, carboxymethyl ethyl cellulose, etc. is dissolved in an alkaline aqueous solution (the alkali is e.g. alkali metal hydroxide or carbonate, or ammonia), a carboxylic acid is added to the solution in an amount of >=50%, preferably >=60% equivalent of the alkali, and the resultant solution is applied to a solid drug such as tablet, capsule, etc. by conventional method. To prevent the precipitation of large gelatinous lumps, the carboxylic acid is diluted with water (usually to a concentration of <=5wt%) and added slowly to the solution under vigorous agitation. EFFECT:The problems inevitable to organic solvents, e.g. hazards of fire and explosion, pollution of working, environment residual solvent in the coating layer, etc. can be solved.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PREPARATION OF DRUG HAVING ENTERIC COATING |
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