OPTICALLY ACTIVE AND CERAMIC 111OXOOPROSTAGLANDIN DERIVATIVES PROCESS FOR MANUFACTURE THEREOF AND PROSTAGLANDINNWORKING AGENTS CONTAINING SAID COMPOUNDS
11-Oxoprostaglandin derivatives of the formula wherein R2 is a hydrogen atom or alkyl of 1-5 carbon atoms, R3 is alkyl of 1-5 carbon atoms, alkylaryl, cycloalkyl of 5-6 ring carbon atoms and a total of 5-10 carbon atoms; benzodioxol-2-yl, phenyl, naphthyl or phenyl or naphthyl substituted by phenyl,...
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| creator | BARUTAA ERUGAA ETSUKEHARUTO SHIRINGAA HERUMUUTO FUORUBURIYUTSUGEN ORAFU ROGE BERUNAA SUKUBARA BERUNTO RADEYUTSUHERU |
| description | 11-Oxoprostaglandin derivatives of the formula wherein R2 is a hydrogen atom or alkyl of 1-5 carbon atoms, R3 is alkyl of 1-5 carbon atoms, alkylaryl, cycloalkyl of 5-6 ring carbon atoms and a total of 5-10 carbon atoms; benzodioxol-2-yl, phenyl, naphthyl or phenyl or naphthyl substituted by phenyl, halogen, alkyl of 1-4 carbon atoms, chloromethyl, fluoromethyl, carboxyl or hydroxy; A is -CH2-CH2-, cis-CH=CH-, or trans-CH=CH-; B is -CH2-CH2- or trans-CH=CH-, D and E collectively are a direct bond or D is alkylene of 1-5 carbon atoms and E is an oxygen or sulfur atom; esters thereof; readily cleavable 9,15 and 9,15 ethers thereof; methanesulfonylamides thereof, and physiologically acceptable salts thereof with bases; possess the activity of the corresponding natural prostaglandins with a surprisingly longer duration of effectiveness, greater selectivity, and better effects, and can be produced, e.g., by oxidation of the corresponding 9-hydroxy prostaglandins. |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | OPTICALLY ACTIVE AND CERAMIC 111OXOOPROSTAGLANDIN DERIVATIVES PROCESS FOR MANUFACTURE THEREOF AND PROSTAGLANDINNWORKING AGENTS CONTAINING SAID COMPOUNDS |
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