PRODUCTION OF AZITHROMYCIN DIHYDRATE

PROBLEM TO BE SOLVED: To obtain an azithromycin dihydrate thermodynamically stable and useful as a medicine in a high yield by adding a base to an aqueous solution of azithromycin using a specific solvent. SOLUTION: This azithromycin dihydrate is obtained by adding a base (preferably sodium hydroxid...

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Hauptverfasser:	BANDARRA JOAO, MENDEZ ZITA, HEGGIE WILLIAM DR
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Sprache:	eng
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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creator	BANDARRA JOAO MENDEZ ZITA HEGGIE WILLIAM DR
description	PROBLEM TO BE SOLVED: To obtain an azithromycin dihydrate thermodynamically stable and useful as a medicine in a high yield by adding a base to an aqueous solution of azithromycin using a specific solvent. SOLUTION: This azithromycin dihydrate is obtained by adding a base (preferably sodium hydroxide) to an aqueous solution of azithromycin having a pH of 1-5 and containing acetone. Preferably, the aqueous solution is formed by dissolving azithromycin in acidified water (preferably water adjusted with dilute aqueous solution of hydrochloric acid) having a pH of 1-5 and adding acetone. Preferably, the aqueous solution contains water of 3-7 volume times of a weight of azithromycin. Preferably, the weight ratio of (acetone/water) in the aqueous solution is (7/3)-(3/7). A suspension in the reagent of the resultant crystallized azithromycin is stirred at a temp. of 0-25 deg.C for 6-30 hrs to obtain the objective azithromycin dihydrate having high purity in a high yield.
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SOLUTION: This azithromycin dihydrate is obtained by adding a base (preferably sodium hydroxide) to an aqueous solution of azithromycin having a pH of 1-5 and containing acetone. Preferably, the aqueous solution is formed by dissolving azithromycin in acidified water (preferably water adjusted with dilute aqueous solution of hydrochloric acid) having a pH of 1-5 and adding acetone. Preferably, the aqueous solution contains water of 3-7 volume times of a weight of azithromycin. Preferably, the weight ratio of (acetone/water) in the aqueous solution is (7/3)-(3/7). A suspension in the reagent of the resultant crystallized azithromycin is stirred at a temp. of 0-25 deg.C for 6-30 hrs to obtain the objective azithromycin dihydrate having high purity in a high yield.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; DERIVATIVES THEREOF ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991124&DB=EPODOC&CC=JP&NR=H11322776A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991124&DB=EPODOC&CC=JP&NR=H11322776A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>BANDARRA JOAO</creatorcontrib><creatorcontrib>MENDEZ ZITA</creatorcontrib><creatorcontrib>HEGGIE WILLIAM DR</creatorcontrib><title>PRODUCTION OF AZITHROMYCIN DIHYDRATE</title><description>PROBLEM TO BE SOLVED: To obtain an azithromycin dihydrate thermodynamically stable and useful as a medicine in a high yield by adding a base to an aqueous solution of azithromycin using a specific solvent. SOLUTION: This azithromycin dihydrate is obtained by adding a base (preferably sodium hydroxide) to an aqueous solution of azithromycin having a pH of 1-5 and containing acetone. Preferably, the aqueous solution is formed by dissolving azithromycin in acidified water (preferably water adjusted with dilute aqueous solution of hydrochloric acid) having a pH of 1-5 and adding acetone. Preferably, the aqueous solution contains water of 3-7 volume times of a weight of azithromycin. Preferably, the weight ratio of (acetone/water) in the aqueous solution is (7/3)-(3/7). 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SOLUTION: This azithromycin dihydrate is obtained by adding a base (preferably sodium hydroxide) to an aqueous solution of azithromycin having a pH of 1-5 and containing acetone. Preferably, the aqueous solution is formed by dissolving azithromycin in acidified water (preferably water adjusted with dilute aqueous solution of hydrochloric acid) having a pH of 1-5 and adding acetone. Preferably, the aqueous solution contains water of 3-7 volume times of a weight of azithromycin. Preferably, the weight ratio of (acetone/water) in the aqueous solution is (7/3)-(3/7). A suspension in the reagent of the resultant crystallized azithromycin is stirred at a temp. of 0-25 deg.C for 6-30 hrs to obtain the objective azithromycin dihydrate having high purity in a high yield.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
title	PRODUCTION OF AZITHROMYCIN DIHYDRATE
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