ACETAMIDE DERIVATIVE AND ITS USE
PROBLEM TO BE SOLVED: To obtain the novel subject acetamide derivative which has a strong cholesterol acyl transferase (Co-A) inhibitory action, particularly high effective for arteriosclerosis. SOLUTION: This acetamide derivative is represented by formula I [R1 and R2 are H, a halogen, a lower alhy...
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| creator | MAEDA KOJI YAMAGUCHI KATSUSHI SUZUKI TOMOO FUCHIGAMI MASAHIRO KATOU NORIYASU KIMURA HIROMOTO MITANI TAKAHIKO TASHIMO SATOSHI |
| description | PROBLEM TO BE SOLVED: To obtain the novel subject acetamide derivative which has a strong cholesterol acyl transferase (Co-A) inhibitory action, particularly high effective for arteriosclerosis. SOLUTION: This acetamide derivative is represented by formula I [R1 and R2 are H, a halogen, a lower alhyl, a lower alkoxy; X is a single bond, O, s, -CH=CH-, -N=CH-; Y is a single bond, >C=O, >CH-R3 (R3 is a lower alkyl); m is 0-4; n is 0 or 1], typically 3, 4-dihydro-N-(2,6-diisopropylphenyl)-1(2H)- quinolineacetoamide. The compound is prepared, for example, by formulating compounds of formula II and formula III at a molar ratio of 1/2-2/1 and allowing them to react with each other in a solvent such as toluene at a temperature of -70-+150 deg.C. The daily dose of this compound is usually about 0.1-100mg in the case of oral administration. |
| format | Patent |
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SOLUTION: This acetamide derivative is represented by formula I [R1 and R2 are H, a halogen, a lower alhyl, a lower alkoxy; X is a single bond, O, s, -CH=CH-, -N=CH-; Y is a single bond, >C=O, >CH-R3 (R3 is a lower alkyl); m is 0-4; n is 0 or 1], typically 3, 4-dihydro-N-(2,6-diisopropylphenyl)-1(2H)- quinolineacetoamide. The compound is prepared, for example, by formulating compounds of formula II and formula III at a molar ratio of 1/2-2/1 and allowing them to react with each other in a solvent such as toluene at a temperature of -70-+150 deg.C. The daily dose of this compound is usually about 0.1-100mg in the case of oral administration.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980414&DB=EPODOC&CC=JP&NR=H1095766A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980414&DB=EPODOC&CC=JP&NR=H1095766A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MAEDA KOJI</creatorcontrib><creatorcontrib>YAMAGUCHI KATSUSHI</creatorcontrib><creatorcontrib>SUZUKI TOMOO</creatorcontrib><creatorcontrib>FUCHIGAMI MASAHIRO</creatorcontrib><creatorcontrib>KATOU NORIYASU</creatorcontrib><creatorcontrib>KIMURA HIROMOTO</creatorcontrib><creatorcontrib>MITANI TAKAHIKO</creatorcontrib><creatorcontrib>TASHIMO SATOSHI</creatorcontrib><title>ACETAMIDE DERIVATIVE AND ITS USE</title><description>PROBLEM TO BE SOLVED: To obtain the novel subject acetamide derivative which has a strong cholesterol acyl transferase (Co-A) inhibitory action, particularly high effective for arteriosclerosis. SOLUTION: This acetamide derivative is represented by formula I [R1 and R2 are H, a halogen, a lower alhyl, a lower alkoxy; X is a single bond, O, s, -CH=CH-, -N=CH-; Y is a single bond, >C=O, >CH-R3 (R3 is a lower alkyl); m is 0-4; n is 0 or 1], typically 3, 4-dihydro-N-(2,6-diisopropylphenyl)-1(2H)- quinolineacetoamide. The compound is prepared, for example, by formulating compounds of formula II and formula III at a molar ratio of 1/2-2/1 and allowing them to react with each other in a solvent such as toluene at a temperature of -70-+150 deg.C. The daily dose of this compound is usually about 0.1-100mg in the case of oral administration.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBwdHYNcfT1dHFVcHEN8gxzDPEMc1Vw9HNR8AwJVggNduVhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfFeAR6GBpam5mZmjsZEKAEApIchiw</recordid><startdate>19980414</startdate><enddate>19980414</enddate><creator>MAEDA KOJI</creator><creator>YAMAGUCHI KATSUSHI</creator><creator>SUZUKI TOMOO</creator><creator>FUCHIGAMI MASAHIRO</creator><creator>KATOU NORIYASU</creator><creator>KIMURA HIROMOTO</creator><creator>MITANI TAKAHIKO</creator><creator>TASHIMO SATOSHI</creator><scope>EVB</scope></search><sort><creationdate>19980414</creationdate><title>ACETAMIDE DERIVATIVE AND ITS USE</title><author>MAEDA KOJI ; YAMAGUCHI KATSUSHI ; SUZUKI TOMOO ; FUCHIGAMI MASAHIRO ; KATOU NORIYASU ; KIMURA HIROMOTO ; MITANI TAKAHIKO ; TASHIMO SATOSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH1095766A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1998</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MAEDA KOJI</creatorcontrib><creatorcontrib>YAMAGUCHI KATSUSHI</creatorcontrib><creatorcontrib>SUZUKI TOMOO</creatorcontrib><creatorcontrib>FUCHIGAMI MASAHIRO</creatorcontrib><creatorcontrib>KATOU NORIYASU</creatorcontrib><creatorcontrib>KIMURA HIROMOTO</creatorcontrib><creatorcontrib>MITANI TAKAHIKO</creatorcontrib><creatorcontrib>TASHIMO SATOSHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MAEDA KOJI</au><au>YAMAGUCHI KATSUSHI</au><au>SUZUKI TOMOO</au><au>FUCHIGAMI MASAHIRO</au><au>KATOU NORIYASU</au><au>KIMURA HIROMOTO</au><au>MITANI TAKAHIKO</au><au>TASHIMO SATOSHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ACETAMIDE DERIVATIVE AND ITS USE</title><date>1998-04-14</date><risdate>1998</risdate><abstract>PROBLEM TO BE SOLVED: To obtain the novel subject acetamide derivative which has a strong cholesterol acyl transferase (Co-A) inhibitory action, particularly high effective for arteriosclerosis. SOLUTION: This acetamide derivative is represented by formula I [R1 and R2 are H, a halogen, a lower alhyl, a lower alkoxy; X is a single bond, O, s, -CH=CH-, -N=CH-; Y is a single bond, >C=O, >CH-R3 (R3 is a lower alkyl); m is 0-4; n is 0 or 1], typically 3, 4-dihydro-N-(2,6-diisopropylphenyl)-1(2H)- quinolineacetoamide. The compound is prepared, for example, by formulating compounds of formula II and formula III at a molar ratio of 1/2-2/1 and allowing them to react with each other in a solvent such as toluene at a temperature of -70-+150 deg.C. The daily dose of this compound is usually about 0.1-100mg in the case of oral administration.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ACETAMIDE DERIVATIVE AND ITS USE |
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