ISOTETRACENE COMPOUND

PROBLEM TO BE SOLVED: To obtain a new specific isotetracene compound that has cell adhesion inhibitory action on ICAM-1 participating in T-lymphocyte function manifestation and extravascular infiltration of phlogocytes and is used as an immunosuppressive agent, antiinflammatory agent, antirheumatic agent, etc. SOLUTION: This new isotetracene compound of formula I or II, which has an adhesion inhibitory action on a cell adhesion molecule, ICAM-1, which develops on antigen manifesting cells, autoimmune target cells and vascular endothelial cells, is combined with LFA-1 on T lmpocytes and inflammation- related immune cells, and fully participates in function manifestation of T lymphocytes and extravascular infiltration of phlogocytes, and is useful as an immunosuppressive agent, antiinflammatory agent, antirheumatic agent, etc., is obtained by inoculating Actinomadura rugatobispora TA-0281 (FERM P-15756) on a medium, culturing the inoculated medium at 28 deg.C for 96hr while stirring under condition of aeration, then passing the culture medium through an adsorption resin column, etc., eluting the adsorbate, and partitioning the elute through a column chromatography, etc.