PYRIDINE COMPOUND

PROBLEM TO BE SOLVED: To obtain a pyridine compound having selectively excellent antimictibial action and gastric acid secretion-suppressing action on Halicobacter pylori and useful as an antiulcer agent hardly causing adverse effects or an agent for preventing recrudescence and relapse of ulcer. SO...

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Hauptverfasser: SANO MITSUHARU, SAKURAI NOBUHIRO, KAWAKITA TAKESHI, IKEDA TAKASHI
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creator SANO MITSUHARU
SAKURAI NOBUHIRO
KAWAKITA TAKESHI
IKEDA TAKASHI
description PROBLEM TO BE SOLVED: To obtain a pyridine compound having selectively excellent antimictibial action and gastric acid secretion-suppressing action on Halicobacter pylori and useful as an antiulcer agent hardly causing adverse effects or an agent for preventing recrudescence and relapse of ulcer. SOLUTION: This pyridine compound is represented by formula I R is H, a halogen, etc.; R and R are each H, an alkyl, an alkoxy, etc.; R is COOR , etc.; R is an alkyl, a haloalkyl, etc.; D is a cycloalkyl, a group, etc., expressed by formula II; R and R are each an acyl, etc.; E is an alkylene; Z and Y are each CH or N; (p) or (q) are each 0, 1 or 2; (m) is an integer of 1-1000}, e.g. 2-((3-methyl-4-(2-(2-(2,2,2-trifluoroethoxy)ethoxy)ethylsulfanyl)-2- pyridyl)methylsulfanyl)-1Hbenzimidazole. The compound of formula I is preferably jointly used with an antiulcer medicine, an antibiotic or an antiprotozoan medicine.
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SOLUTION: This pyridine compound is represented by formula I R is H, a halogen, etc.; R and R are each H, an alkyl, an alkoxy, etc.; R is COOR , etc.; R is an alkyl, a haloalkyl, etc.; D is a cycloalkyl, a group, etc., expressed by formula II; R and R are each an acyl, etc.; E is an alkylene; Z and Y are each CH or N; (p) or (q) are each 0, 1 or 2; (m) is an integer of 1-1000}, e.g. 2-((3-methyl-4-(2-(2-(2,2,2-trifluoroethoxy)ethoxy)ethylsulfanyl)-2- pyridyl)methylsulfanyl)-1Hbenzimidazole. 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SOLUTION: This pyridine compound is represented by formula I R is H, a halogen, etc.; R and R are each H, an alkyl, an alkoxy, etc.; R is COOR , etc.; R is an alkyl, a haloalkyl, etc.; D is a cycloalkyl, a group, etc., expressed by formula II; R and R are each an acyl, etc.; E is an alkylene; Z and Y are each CH or N; (p) or (q) are each 0, 1 or 2; (m) is an integer of 1-1000}, e.g. 2-((3-methyl-4-(2-(2-(2,2,2-trifluoroethoxy)ethoxy)ethylsulfanyl)-2- pyridyl)methylsulfanyl)-1Hbenzimidazole. The compound of formula I is preferably jointly used with an antiulcer medicine, an antibiotic or an antiprotozoan medicine.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAMiAzydPH0c1Vw9vcN8A_1c-FhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfFeAR6GBsZmxmbmjsZEKAEA-LEdtQ</recordid><startdate>19980210</startdate><enddate>19980210</enddate><creator>SANO MITSUHARU</creator><creator>SAKURAI NOBUHIRO</creator><creator>KAWAKITA TAKESHI</creator><creator>IKEDA TAKASHI</creator><scope>EVB</scope></search><sort><creationdate>19980210</creationdate><title>PYRIDINE COMPOUND</title><author>SANO MITSUHARU ; SAKURAI NOBUHIRO ; KAWAKITA TAKESHI ; IKEDA TAKASHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH1036367A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1998</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SANO MITSUHARU</creatorcontrib><creatorcontrib>SAKURAI NOBUHIRO</creatorcontrib><creatorcontrib>KAWAKITA TAKESHI</creatorcontrib><creatorcontrib>IKEDA TAKASHI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SANO MITSUHARU</au><au>SAKURAI NOBUHIRO</au><au>KAWAKITA TAKESHI</au><au>IKEDA TAKASHI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRIDINE COMPOUND</title><date>1998-02-10</date><risdate>1998</risdate><abstract>PROBLEM TO BE SOLVED: To obtain a pyridine compound having selectively excellent antimictibial action and gastric acid secretion-suppressing action on Halicobacter pylori and useful as an antiulcer agent hardly causing adverse effects or an agent for preventing recrudescence and relapse of ulcer. SOLUTION: This pyridine compound is represented by formula I R is H, a halogen, etc.; R and R are each H, an alkyl, an alkoxy, etc.; R is COOR , etc.; R is an alkyl, a haloalkyl, etc.; D is a cycloalkyl, a group, etc., expressed by formula II; R and R are each an acyl, etc.; E is an alkylene; Z and Y are each CH or N; (p) or (q) are each 0, 1 or 2; (m) is an integer of 1-1000}, e.g. 2-((3-methyl-4-(2-(2-(2,2,2-trifluoroethoxy)ethoxy)ethylsulfanyl)-2- pyridyl)methylsulfanyl)-1Hbenzimidazole. The compound of formula I is preferably jointly used with an antiulcer medicine, an antibiotic or an antiprotozoan medicine.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title PYRIDINE COMPOUND
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