BICYCLIC AROMATIC AMIDINE DERIVATIVE

PROBLEM TO BE SOLVED: To obtain the subject new compound shown by a specific formula, having blood coagulation factor Xa inhibitory activity, thus useful as a preventive/therapeutic agent for diseases due to thrombus, embolism, etc. SOLUTION: This new compound is shown by formula I (Ar is benzene ri...

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Hauptverfasser:	KAWAMOTO HIROSHI, NOMOTO TAKASHI, HAYASHI KYOKO, MIYAJI MITSURU, SATO YOSHIYUKI, TAKAENOKI YOUKO
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Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	KAWAMOTO HIROSHI NOMOTO TAKASHI HAYASHI KYOKO MIYAJI MITSURU SATO YOSHIYUKI TAKAENOKI YOUKO
description	PROBLEM TO BE SOLVED: To obtain the subject new compound shown by a specific formula, having blood coagulation factor Xa inhibitory activity, thus useful as a preventive/therapeutic agent for diseases due to thrombus, embolism, etc. SOLUTION: This new compound is shown by formula I (Ar is benzene ring or a heteroaromatic ring bearing 1 to 3 heteroatom(s); Q is a 3-7C alkylene, alkenylene or alkynylene; Y is a 5- to 10-membered monocyclic or bicyclic heterocyclic group bearing at least one N (atom), e.g. (E)-2-(7-amidino-2- naphthyl)-5-(isoindolin-5-yl)-4-pentenonic ethyl ester dihydrochloride. This compound of formula I is obtained, pref., for example, by reaction of a compound of formula II with hydrogen chloride directly in an alcohol solvent. The compound of formula II is prepared, pref. by uncleophilic substitution reaction between a compound of formula III and a compound of formula IV.
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This compound of formula I is obtained, pref., for example, by reaction of a compound of formula II with hydrogen chloride directly in an alcohol solvent. The compound of formula II is prepared, pref. by uncleophilic substitution reaction between a compound of formula III and a compound of formula IV.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1998</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980120&DB=EPODOC&CC=JP&NR=H1017549A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19980120&DB=EPODOC&CC=JP&NR=H1017549A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KAWAMOTO HIROSHI</creatorcontrib><creatorcontrib>NOMOTO TAKASHI</creatorcontrib><creatorcontrib>HAYASHI KYOKO</creatorcontrib><creatorcontrib>MIYAJI MITSURU</creatorcontrib><creatorcontrib>SATO YOSHIYUKI</creatorcontrib><creatorcontrib>TAKAENOKI YOUKO</creatorcontrib><title>BICYCLIC AROMATIC AMIDINE DERIVATIVE</title><description>PROBLEM TO BE SOLVED: To obtain the subject new compound shown by a specific formula, having blood coagulation factor Xa inhibitory activity, thus useful as a preventive/therapeutic agent for diseases due to thrombus, embolism, etc. SOLUTION: This new compound is shown by formula I (Ar is benzene ring or a heteroaromatic ring bearing 1 to 3 heteroatom(s); Q is a 3-7C alkylene, alkenylene or alkynylene; Y is a 5- to 10-membered monocyclic or bicyclic heterocyclic group bearing at least one N (atom), e.g. (E)-2-(7-amidino-2- naphthyl)-5-(isoindolin-5-yl)-4-pentenonic ethyl ester dihydrochloride. 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The compound of formula II is prepared, pref. by uncleophilic substitution reaction between a compound of formula III and a compound of formula IV.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1998</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBx8nSOdPbxdFZwDPL3dQwBMXw9XTz9XBVcXIM8w4AiYa48DKxpiTnFqbxQmptBwc01xNlDN7UgPz61uCAxOTUvtSTeK8DD0MDQ3NTE0tGYCCUANcgivQ</recordid><startdate>19980120</startdate><enddate>19980120</enddate><creator>KAWAMOTO HIROSHI</creator><creator>NOMOTO TAKASHI</creator><creator>HAYASHI KYOKO</creator><creator>MIYAJI MITSURU</creator><creator>SATO YOSHIYUKI</creator><creator>TAKAENOKI YOUKO</creator><scope>EVB</scope></search><sort><creationdate>19980120</creationdate><title>BICYCLIC AROMATIC AMIDINE DERIVATIVE</title><author>KAWAMOTO HIROSHI ; NOMOTO TAKASHI ; HAYASHI KYOKO ; MIYAJI MITSURU ; SATO YOSHIYUKI ; TAKAENOKI YOUKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH1017549A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1998</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KAWAMOTO HIROSHI</creatorcontrib><creatorcontrib>NOMOTO TAKASHI</creatorcontrib><creatorcontrib>HAYASHI KYOKO</creatorcontrib><creatorcontrib>MIYAJI MITSURU</creatorcontrib><creatorcontrib>SATO YOSHIYUKI</creatorcontrib><creatorcontrib>TAKAENOKI YOUKO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KAWAMOTO HIROSHI</au><au>NOMOTO TAKASHI</au><au>HAYASHI KYOKO</au><au>MIYAJI MITSURU</au><au>SATO YOSHIYUKI</au><au>TAKAENOKI YOUKO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>BICYCLIC AROMATIC AMIDINE DERIVATIVE</title><date>1998-01-20</date><risdate>1998</risdate><abstract>PROBLEM TO BE SOLVED: To obtain the subject new compound shown by a specific formula, having blood coagulation factor Xa inhibitory activity, thus useful as a preventive/therapeutic agent for diseases due to thrombus, embolism, etc. SOLUTION: This new compound is shown by formula I (Ar is benzene ring or a heteroaromatic ring bearing 1 to 3 heteroatom(s); Q is a 3-7C alkylene, alkenylene or alkynylene; Y is a 5- to 10-membered monocyclic or bicyclic heterocyclic group bearing at least one N (atom), e.g. (E)-2-(7-amidino-2- naphthyl)-5-(isoindolin-5-yl)-4-pentenonic ethyl ester dihydrochloride. This compound of formula I is obtained, pref., for example, by reaction of a compound of formula II with hydrogen chloride directly in an alcohol solvent. The compound of formula II is prepared, pref. by uncleophilic substitution reaction between a compound of formula III and a compound of formula IV.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	BICYCLIC AROMATIC AMIDINE DERIVATIVE
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