INHIBITOR OF PROTEIN DEPHOSPHORYLASE
PROBLEM TO BE SOLVED: To obtain an inhibitor of a protein dephosphorylase, comprising a pyrrolidone derivative as an active ingredient and useful as an antitumor agent, an immunosuppressant, a therapeutic agent for diabetes, etc. SOLUTION: This inhibitor of a protein dephosphorylase comprises a comp...
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| creator | SATO MASAKAZU OSADA HIROYUKI ARAI YOSHIFUMI KAGAMIZONO TERUMI |
| description | PROBLEM TO BE SOLVED: To obtain an inhibitor of a protein dephosphorylase, comprising a pyrrolidone derivative as an active ingredient and useful as an antitumor agent, an immunosuppressant, a therapeutic agent for diabetes, etc. SOLUTION: This inhibitor of a protein dephosphorylase comprises a compound of formula I (R is methyl, or together with R denotes =CH2 ; R is OH, a 1-10C alkoxy, a halogen or nitroxy; R is cyano, a 2-10C alkanoyl or formula II) or its salt as an active ingredient. The compound of formula I is preferably obtained by condensing 2,3-dioxobutane with a compound of the formula R CH2 CONH2 and treating the resultant compound with an acid (e.g. 10-camphorsulfonic acid). The compound of formula I is directly used or formulated into a preparation according to a conventional method and used as the inhibitor of the protein dephosphorylase. 3-Cyano-4-methyl-5-vinylidene-2- pyrrolidone is exemplified as the compound of formula I. |
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The compound of formula I is preferably obtained by condensing 2,3-dioxobutane with a compound of the formula R CH2 CONH2 and treating the resultant compound with an acid (e.g. 10-camphorsulfonic acid). The compound of formula I is directly used or formulated into a preparation according to a conventional method and used as the inhibitor of the protein dephosphorylase. 3-Cyano-4-methyl-5-vinylidene-2- pyrrolidone is exemplified as the compound of formula I.</description><edition>6</edition><language>eng</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1997</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970916&DB=EPODOC&CC=JP&NR=H09241160A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19970916&DB=EPODOC&CC=JP&NR=H09241160A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SATO MASAKAZU</creatorcontrib><creatorcontrib>OSADA HIROYUKI</creatorcontrib><creatorcontrib>ARAI YOSHIFUMI</creatorcontrib><creatorcontrib>KAGAMIZONO TERUMI</creatorcontrib><title>INHIBITOR OF PROTEIN DEPHOSPHORYLASE</title><description>PROBLEM TO BE SOLVED: To obtain an inhibitor of a protein dephosphorylase, comprising a pyrrolidone derivative as an active ingredient and useful as an antitumor agent, an immunosuppressant, a therapeutic agent for diabetes, etc. SOLUTION: This inhibitor of a protein dephosphorylase comprises a compound of formula I (R is methyl, or together with R denotes =CH2 ; R is OH, a 1-10C alkoxy, a halogen or nitroxy; R is cyano, a 2-10C alkanoyl or formula II) or its salt as an active ingredient. The compound of formula I is preferably obtained by condensing 2,3-dioxobutane with a compound of the formula R CH2 CONH2 and treating the resultant compound with an acid (e.g. 10-camphorsulfonic acid). 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The compound of formula I is preferably obtained by condensing 2,3-dioxobutane with a compound of the formula R CH2 CONH2 and treating the resultant compound with an acid (e.g. 10-camphorsulfonic acid). The compound of formula I is directly used or formulated into a preparation according to a conventional method and used as the inhibitor of the protein dephosphorylase. 3-Cyano-4-methyl-5-vinylidene-2- pyrrolidone is exemplified as the compound of formula I.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | INHIBITOR OF PROTEIN DEPHOSPHORYLASE |
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