BENZANILIDE DERIVATIVE

PURPOSE:To obtain a compound, having strong and selective bronchodilator actions and useful as a therapeutic agent for airway disorders such as reversible airway obstruction or asthma. CONSTITUTION:This compound is expressed by formula I (R is H, a 1-6C alkyl, a 1-6C alkoxy, a halogen, cyano, a trih...

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Hauptverfasser:	IKAWA HIROSHI, SHOJI TSUNEO, KAKUIRI AKIHITO
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Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator	IKAWA HIROSHI SHOJI TSUNEO KAKUIRI AKIHITO
description	PURPOSE:To obtain a compound, having strong and selective bronchodilator actions and useful as a therapeutic agent for airway disorders such as reversible airway obstruction or asthma. CONSTITUTION:This compound is expressed by formula I (R is H, a 1-6C alkyl, a 1-6C alkoxy, a halogen, cyano, a trihalomethyl or nitro), e.g. 2- isopropyloxy-5-nitrobenzanilide. The compound of formula I is obtained by reacting a benzoic acid derivative of formula II (Z is OH, a halogen, an acyloxy or an active ester residue) with an aniline derivative of formula III. When Z in the compound of formula II is OH, the reaction is carried out in the presence of a dehydration condensing agent (e.g. dicyclohexylcarbodiimide) in a solvent (e.g. dichloromethane) at 0-150 deg.C, preferably in an inert gas atmosphere (e.g. nitrogen gas).
format	Patent
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CONSTITUTION:This compound is expressed by formula I (R is H, a 1-6C alkyl, a 1-6C alkoxy, a halogen, cyano, a trihalomethyl or nitro), e.g. 2- isopropyloxy-5-nitrobenzanilide. The compound of formula I is obtained by reacting a benzoic acid derivative of formula II (Z is OH, a halogen, an acyloxy or an active ester residue) with an aniline derivative of formula III. When Z in the compound of formula II is OH, the reaction is carried out in the presence of a dehydration condensing agent (e.g. dicyclohexylcarbodiimide) in a solvent (e.g. dichloromethane) at 0-150 deg.C, preferably in an inert gas atmosphere (e.g. nitrogen gas).</description><edition>6</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960220&DB=EPODOC&CC=JP&NR=H0848663A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76419</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960220&DB=EPODOC&CC=JP&NR=H0848663A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IKAWA HIROSHI</creatorcontrib><creatorcontrib>SHOJI TSUNEO</creatorcontrib><creatorcontrib>KAKUIRI AKIHITO</creatorcontrib><title>BENZANILIDE DERIVATIVE</title><description>PURPOSE:To obtain a compound, having strong and selective bronchodilator actions and useful as a therapeutic agent for airway disorders such as reversible airway obstruction or asthma. 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CONSTITUTION:This compound is expressed by formula I (R is H, a 1-6C alkyl, a 1-6C alkoxy, a halogen, cyano, a trihalomethyl or nitro), e.g. 2- isopropyloxy-5-nitrobenzanilide. The compound of formula I is obtained by reacting a benzoic acid derivative of formula II (Z is OH, a halogen, an acyloxy or an active ester residue) with an aniline derivative of formula III. When Z in the compound of formula II is OH, the reaction is carried out in the presence of a dehydration condensing agent (e.g. dicyclohexylcarbodiimide) in a solvent (e.g. dichloromethane) at 0-150 deg.C, preferably in an inert gas atmosphere (e.g. nitrogen gas).</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title	BENZANILIDE DERIVATIVE
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