DITERPENES
PURPOSE: To obtain new diterpenes isolated from Stellerae radix as a specific kind of herb crude drug, expressed by a specific formula, having potent anti- AIDS virus action, thus useful as an anti-AIDS virus agent. CONSTITUTION: The subject new compounds are expressed by formula I (R1 is CH2 CO or...
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| creator | IKEGAWA AKIKO IKEGAWA TETSUO |
| description | PURPOSE: To obtain new diterpenes isolated from Stellerae radix as a specific kind of herb crude drug, expressed by a specific formula, having potent anti- AIDS virus action, thus useful as an anti-AIDS virus agent. CONSTITUTION: The subject new compounds are expressed by formula I (R1 is CH2 CO or of formula II; R2 is CH3 CO, CH3 (CH2 )8 CO or of formula II) and obtained by the following process: an ester extracted by a lower alcohol from the ground and/or underground portion(s) of Stellerae radix as a kind of herb crud drug is subjected to silica gel chromatography, and the eluted part obtained using a hexane-ethyl acetate (1:4) mixed solvent is subjected to reversed phase chromatography and methanol/water treatment to obtain gnidimacrin, stelleramacrin and simplexin, and the fraction with high anti-AIDS virus activity containing the above substances is purified through open column chromatography, and the resultant diterpenes are further purified through dispensing thin-layer chromatography. |
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CONSTITUTION: The subject new compounds are expressed by formula I (R1 is CH2 CO or of formula II; R2 is CH3 CO, CH3 (CH2 )8 CO or of formula II) and obtained by the following process: an ester extracted by a lower alcohol from the ground and/or underground portion(s) of Stellerae radix as a kind of herb crud drug is subjected to silica gel chromatography, and the eluted part obtained using a hexane-ethyl acetate (1:4) mixed solvent is subjected to reversed phase chromatography and methanol/water treatment to obtain gnidimacrin, stelleramacrin and simplexin, and the fraction with high anti-AIDS virus activity containing the above substances is purified through open column chromatography, and the resultant diterpenes are further purified through dispensing thin-layer chromatography.</description><edition>6</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961126&DB=EPODOC&CC=JP&NR=H08310993A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961126&DB=EPODOC&CC=JP&NR=H08310993A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>IKEGAWA AKIKO</creatorcontrib><creatorcontrib>IKEGAWA TETSUO</creatorcontrib><title>DITERPENES</title><description>PURPOSE: To obtain new diterpenes isolated from Stellerae radix as a specific kind of herb crude drug, expressed by a specific formula, having potent anti- AIDS virus action, thus useful as an anti-AIDS virus agent. CONSTITUTION: The subject new compounds are expressed by formula I (R1 is CH2 CO or of formula II; R2 is CH3 CO, CH3 (CH2 )8 CO or of formula II) and obtained by the following process: an ester extracted by a lower alcohol from the ground and/or underground portion(s) of Stellerae radix as a kind of herb crud drug is subjected to silica gel chromatography, and the eluted part obtained using a hexane-ethyl acetate (1:4) mixed solvent is subjected to reversed phase chromatography and methanol/water treatment to obtain gnidimacrin, stelleramacrin and simplexin, and the fraction with high anti-AIDS virus activity containing the above substances is purified through open column chromatography, and the resultant diterpenes are further purified through dispensing thin-layer chromatography.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZOBy8QxxDQpw9XMN5mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8V4BHgYWxoYGlpbGjsbEqAEAZiwcKA</recordid><startdate>19961126</startdate><enddate>19961126</enddate><creator>IKEGAWA AKIKO</creator><creator>IKEGAWA TETSUO</creator><scope>EVB</scope></search><sort><creationdate>19961126</creationdate><title>DITERPENES</title><author>IKEGAWA AKIKO ; IKEGAWA TETSUO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH08310993A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1996</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>IKEGAWA AKIKO</creatorcontrib><creatorcontrib>IKEGAWA TETSUO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>IKEGAWA AKIKO</au><au>IKEGAWA TETSUO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>DITERPENES</title><date>1996-11-26</date><risdate>1996</risdate><abstract>PURPOSE: To obtain new diterpenes isolated from Stellerae radix as a specific kind of herb crude drug, expressed by a specific formula, having potent anti- AIDS virus action, thus useful as an anti-AIDS virus agent. CONSTITUTION: The subject new compounds are expressed by formula I (R1 is CH2 CO or of formula II; R2 is CH3 CO, CH3 (CH2 )8 CO or of formula II) and obtained by the following process: an ester extracted by a lower alcohol from the ground and/or underground portion(s) of Stellerae radix as a kind of herb crud drug is subjected to silica gel chromatography, and the eluted part obtained using a hexane-ethyl acetate (1:4) mixed solvent is subjected to reversed phase chromatography and methanol/water treatment to obtain gnidimacrin, stelleramacrin and simplexin, and the fraction with high anti-AIDS virus activity containing the above substances is purified through open column chromatography, and the resultant diterpenes are further purified through dispensing thin-layer chromatography.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | DITERPENES |
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