ANTITUMOR AGENT HAVING HIGH TRANSITION TO CANCER TISSUE
PURPOSE: To obtain an antitumor agent capable of safely taking an antitumor agent in low-density lipoprotein(LDL) in in vivo without using an isolated material of LDL or or a solubilizing agent by binding a steroidal compound to a water-soluble compound and binding the steroidal compound to an antit...
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| creator | ISHIKURA TOYOAKI ITO TERUOMI |
| description | PURPOSE: To obtain an antitumor agent capable of safely taking an antitumor agent in low-density lipoprotein(LDL) in in vivo without using an isolated material of LDL or or a solubilizing agent by binding a steroidal compound to a water-soluble compound and binding the steroidal compound to an antitumor agent. CONSTITUTION: This antitumor agent is obtained by binding (A) a steroidal compound of formula I [A is an amino or OH; B is methyl, carboxyl, etc.; D is H or OH; E is B; G is D; F is a (substituted)3-9C (branched) alkyl, with the proviso that when F has no functional group, at least one of B, D, E and F is A or carboxyl], formula II or formula III to (B) a water-soluble compound such as phosphoric acid, sulfuric acid, succinic acid, maleic acid or methylmalonic acid by ester bond of one OH group of the component A with an acidic functional group or carboxyl of the component B and binding the component A to (C) a carcinostatic agent by urethane bond, acid amino bond or ester bond of OH, carboxyl and amino of the component A with a functional group of the component C. |
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CONSTITUTION: This antitumor agent is obtained by binding (A) a steroidal compound of formula I [A is an amino or OH; B is methyl, carboxyl, etc.; D is H or OH; E is B; G is D; F is a (substituted)3-9C (branched) alkyl, with the proviso that when F has no functional group, at least one of B, D, E and F is A or carboxyl], formula II or formula III to (B) a water-soluble compound such as phosphoric acid, sulfuric acid, succinic acid, maleic acid or methylmalonic acid by ester bond of one OH group of the component A with an acidic functional group or carboxyl of the component B and binding the component A to (C) a carcinostatic agent by urethane bond, acid amino bond or ester bond of OH, carboxyl and amino of the component A with a functional group of the component C.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; STEROIDS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961015&DB=EPODOC&CC=JP&NR=H08268917A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25551,76302</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19961015&DB=EPODOC&CC=JP&NR=H08268917A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ISHIKURA TOYOAKI</creatorcontrib><creatorcontrib>ITO TERUOMI</creatorcontrib><title>ANTITUMOR AGENT HAVING HIGH TRANSITION TO CANCER TISSUE</title><description>PURPOSE: To obtain an antitumor agent capable of safely taking an antitumor agent in low-density lipoprotein(LDL) in in vivo without using an isolated material of LDL or or a solubilizing agent by binding a steroidal compound to a water-soluble compound and binding the steroidal compound to an antitumor agent. CONSTITUTION: This antitumor agent is obtained by binding (A) a steroidal compound of formula I [A is an amino or OH; B is methyl, carboxyl, etc.; D is H or OH; E is B; G is D; F is a (substituted)3-9C (branched) alkyl, with the proviso that when F has no functional group, at least one of B, D, E and F is A or carboxyl], formula II or formula III to (B) a water-soluble compound such as phosphoric acid, sulfuric acid, succinic acid, maleic acid or methylmalonic acid by ester bond of one OH group of the component A with an acidic functional group or carboxyl of the component B and binding the component A to (C) a carcinostatic agent by urethane bond, acid amino bond or ester bond of OH, carboxyl and amino of the component A with a functional group of the component C.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDB39AvxDAn19Q9ScHR39QtR8HAM8_RzV_DwdPdQCAly9Av2DPH091MI8VdwdvRzdg1SCPEMDg515WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8V4BHgYWRmYWlobmjsbEqAEAT6komA</recordid><startdate>19961015</startdate><enddate>19961015</enddate><creator>ISHIKURA TOYOAKI</creator><creator>ITO TERUOMI</creator><scope>EVB</scope></search><sort><creationdate>19961015</creationdate><title>ANTITUMOR AGENT HAVING HIGH TRANSITION TO CANCER TISSUE</title><author>ISHIKURA TOYOAKI ; ITO TERUOMI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH08268917A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1996</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>ISHIKURA TOYOAKI</creatorcontrib><creatorcontrib>ITO TERUOMI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ISHIKURA TOYOAKI</au><au>ITO TERUOMI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTITUMOR AGENT HAVING HIGH TRANSITION TO CANCER TISSUE</title><date>1996-10-15</date><risdate>1996</risdate><abstract>PURPOSE: To obtain an antitumor agent capable of safely taking an antitumor agent in low-density lipoprotein(LDL) in in vivo without using an isolated material of LDL or or a solubilizing agent by binding a steroidal compound to a water-soluble compound and binding the steroidal compound to an antitumor agent. CONSTITUTION: This antitumor agent is obtained by binding (A) a steroidal compound of formula I [A is an amino or OH; B is methyl, carboxyl, etc.; D is H or OH; E is B; G is D; F is a (substituted)3-9C (branched) alkyl, with the proviso that when F has no functional group, at least one of B, D, E and F is A or carboxyl], formula II or formula III to (B) a water-soluble compound such as phosphoric acid, sulfuric acid, succinic acid, maleic acid or methylmalonic acid by ester bond of one OH group of the component A with an acidic functional group or carboxyl of the component B and binding the component A to (C) a carcinostatic agent by urethane bond, acid amino bond or ester bond of OH, carboxyl and amino of the component A with a functional group of the component C.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS |
| title | ANTITUMOR AGENT HAVING HIGH TRANSITION TO CANCER TISSUE |
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