PYRIDINE-BASED THIAZOLIDINES

PURPOSE: To obtain new compounds, having more improved hypoglycemic actions and further antiglycation and aldose reductase inhibiting activities and low toxicity and useful as a preventing and therapeutic agent for diabetes and its complications. CONSTITUTION: The compounds of formula I [X is S or O...

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Hauptverfasser: OBARA YOSHIO, KATO KATSUHIRO, SUZUKI MIKIO, SHIKADA KENICHI, YOTSUMOTO TAKASHI, OODOI KEISUKE, KOBAYASHI TETSUYA, MIYAJI NOBUHIDE, NAITO TAKESHI
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creator OBARA YOSHIO
KATO KATSUHIRO
SUZUKI MIKIO
SHIKADA KENICHI
YOTSUMOTO TAKASHI
OODOI KEISUKE
KOBAYASHI TETSUYA
MIYAJI NOBUHIDE
NAITO TAKESHI
description PURPOSE: To obtain new compounds, having more improved hypoglycemic actions and further antiglycation and aldose reductase inhibiting activities and low toxicity and useful as a preventing and therapeutic agent for diabetes and its complications. CONSTITUTION: The compounds of formula I [X is S or O; X is O, NH, etc.; Y is SO2 or CR R (R is H, a 1-7C alkyl, etc.; R is H, a 3-7C cycloalkyl, etc.); Z is a 1-10C alkyl, phenyl, etc.; R to R are each H, a halogen, etc.; R is H, or together with R , indicates a bond, etc.; (n) is 0 or 1] are their salts, e.g. 5-((5-(2-oxo-2-(2-phenyl-5-methyl-4-oxazolyl)ethoxy)-2-pyridyl)methyl) thiazolidine-2,4-dione. The compounds are obtained by carrying out the dehydrating condensation of, e.g. a compound of formula II with a compound of formula III (R is H or a protecting group of amide) in an organic solvent in the presence of a base. Furthermore, the compound of formula II is a new substance and prepared by using, e.g. 5-hydroxy-2-picoline as a starting substance.
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CONSTITUTION: The compounds of formula I [X is S or O; X is O, NH, etc.; Y is SO2 or CR R (R is H, a 1-7C alkyl, etc.; R is H, a 3-7C cycloalkyl, etc.); Z is a 1-10C alkyl, phenyl, etc.; R to R are each H, a halogen, etc.; R is H, or together with R , indicates a bond, etc.; (n) is 0 or 1] are their salts, e.g. 5-((5-(2-oxo-2-(2-phenyl-5-methyl-4-oxazolyl)ethoxy)-2-pyridyl)methyl) thiazolidine-2,4-dione. The compounds are obtained by carrying out the dehydrating condensation of, e.g. a compound of formula II with a compound of formula III (R is H or a protecting group of amide) in an organic solvent in the presence of a base. Furthermore, the compound of formula II is a new substance and prepared by using, e.g. 5-hydroxy-2-picoline as a starting substance.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
title PYRIDINE-BASED THIAZOLIDINES
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