BENZAMIDE COMPOUND

PURPOSE: To obtain a benzamide compound shown by a specific formula, useful as a reagent having activities such as antagonistic activity against vasopressin, vasodilating action, antihypertensive action and inhibitory action on release of liver lipid. CONSTITUTION: This compound is shown by formula I R and R together with adjoining C form a (lower alkyl-substituted) benzene ring, pyridine ring or thiophene ring; R is a (substituted) alkenyl, an aryl or a (substituted) heterocyclic ring; A is a group of formula II (R and R are each H or R is H and R is hydroxy or a lower alkylamine or R and R are bound to form oxo); E is a lower alkylene or phenylene; X is CH or N; Y is a single bond or a group of formula III [R is H, tolylbenzoyl or a (substituted) amino]} such as 4-[6-(2,3-dimethylbenzoylamino)nicotinoyl]5,6,7,8-tetrahydro 4H- thieno[3,2-b]azepine. For example, the compound is preferably obtained by reacting a compound of formula IV with a compound of formula V in the presence of a condensation agent.