JPH075629B
The invention relates to novel DELTA -16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means...
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| creator | YOOJEFU TOOTSU JORUJI HAIYOOSHU CHABA MORUNAARU BURUCHUU HEREENYUI KURISUTEINA SEEKERI YAANOSU CHOERUGEI SAANDORU HO AARUPAADO KIRAARI ANNA BOOORU JORUJI FUEKETE RAASUROO SUHORUNYU RITSURA FUORUGAACHU |
| description | The invention relates to novel DELTA -16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen,benzoyl or C18alkanoyl group; R and R , which are the same or different, stand for hydrogen or a C14alkyl group; or one of R and R is hydrogen and the other is phenyl group; or R and R together form a C45alkylene group; --- means a single or double bond between two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy. |
| format | Patent |
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The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; STEROIDS</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950125&DB=EPODOC&CC=JP&NR=H075629B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950125&DB=EPODOC&CC=JP&NR=H075629B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YOOJEFU TOOTSU</creatorcontrib><creatorcontrib>JORUJI HAIYOOSHU</creatorcontrib><creatorcontrib>CHABA MORUNAARU</creatorcontrib><creatorcontrib>BURUCHUU HEREENYUI</creatorcontrib><creatorcontrib>KURISUTEINA SEEKERI</creatorcontrib><creatorcontrib>YAANOSU CHOERUGEI</creatorcontrib><creatorcontrib>SAANDORU HO</creatorcontrib><creatorcontrib>AARUPAADO KIRAARI</creatorcontrib><creatorcontrib>ANNA BOOORU</creatorcontrib><creatorcontrib>JORUJI FUEKETE</creatorcontrib><creatorcontrib>RAASUROO SUHORUNYU</creatorcontrib><creatorcontrib>RITSURA FUORUGAACHU</creatorcontrib><title>JPH075629B</title><description>The invention relates to novel DELTA -16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen,benzoyl or C1<->8alkanoyl group; R and R , which are the same or different, stand for hydrogen or a C1<->4alkyl group; or one of R and R is hydrogen and the other is phenyl group; or R and R together form a C4<->5alkylene group; --- means a single or double bond between two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>STEROIDS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1995</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZODyCvAwMDc1M7J04mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8QgNTkbGxKgBADTYG7g</recordid><startdate>19950125</startdate><enddate>19950125</enddate><creator>YOOJEFU TOOTSU</creator><creator>JORUJI HAIYOOSHU</creator><creator>CHABA MORUNAARU</creator><creator>BURUCHUU HEREENYUI</creator><creator>KURISUTEINA SEEKERI</creator><creator>YAANOSU CHOERUGEI</creator><creator>SAANDORU HO</creator><creator>AARUPAADO KIRAARI</creator><creator>ANNA BOOORU</creator><creator>JORUJI FUEKETE</creator><creator>RAASUROO SUHORUNYU</creator><creator>RITSURA FUORUGAACHU</creator><scope>EVB</scope></search><sort><creationdate>19950125</creationdate><title>JPH075629B</title><author>YOOJEFU TOOTSU ; JORUJI HAIYOOSHU ; CHABA MORUNAARU ; BURUCHUU HEREENYUI ; KURISUTEINA SEEKERI ; YAANOSU CHOERUGEI ; SAANDORU HO ; AARUPAADO KIRAARI ; ANNA BOOORU ; JORUJI FUEKETE ; RAASUROO SUHORUNYU ; RITSURA FUORUGAACHU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH075629BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1995</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>STEROIDS</topic><toplevel>online_resources</toplevel><creatorcontrib>YOOJEFU TOOTSU</creatorcontrib><creatorcontrib>JORUJI HAIYOOSHU</creatorcontrib><creatorcontrib>CHABA MORUNAARU</creatorcontrib><creatorcontrib>BURUCHUU HEREENYUI</creatorcontrib><creatorcontrib>KURISUTEINA SEEKERI</creatorcontrib><creatorcontrib>YAANOSU CHOERUGEI</creatorcontrib><creatorcontrib>SAANDORU HO</creatorcontrib><creatorcontrib>AARUPAADO KIRAARI</creatorcontrib><creatorcontrib>ANNA BOOORU</creatorcontrib><creatorcontrib>JORUJI FUEKETE</creatorcontrib><creatorcontrib>RAASUROO SUHORUNYU</creatorcontrib><creatorcontrib>RITSURA FUORUGAACHU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YOOJEFU TOOTSU</au><au>JORUJI HAIYOOSHU</au><au>CHABA MORUNAARU</au><au>BURUCHUU HEREENYUI</au><au>KURISUTEINA SEEKERI</au><au>YAANOSU CHOERUGEI</au><au>SAANDORU HO</au><au>AARUPAADO KIRAARI</au><au>ANNA BOOORU</au><au>JORUJI FUEKETE</au><au>RAASUROO SUHORUNYU</au><au>RITSURA FUORUGAACHU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>JPH075629B</title><date>1995-01-25</date><risdate>1995</risdate><abstract>The invention relates to novel DELTA -16 alpha ,17-dihydroxy-pregnane-16,17-cyclic aldehyde acetal and -cyclic ketone ketal derivatives of general formula (I), wherein A stands for hydrogen or hydroxyl group; X stands for hydrogen or halogen with the proviso that if A is hydrogen, then X also means hydrogen; R stands for hydrogen,benzoyl or C1<->8alkanoyl group; R and R , which are the same or different, stand for hydrogen or a C1<->4alkyl group; or one of R and R is hydrogen and the other is phenyl group; or R and R together form a C4<->5alkylene group; --- means a single or double bond between two adjacent carbon atoms, as well as pharmaceutical compositions containing these compounds and a process for their preparation. The compounds of general formula (I) possess a very strong antiinflammatory effect and only week harmful side effect. Thus, they can be used as active ingredients of antiinflammatory pharmaceutical compositions being useful in the therapy.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS |
| title | JPH075629B |
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