PRODUCTION OF 2-AMINO-4-PYRIDYLMETHYL-6 HYDROXYBENZOTHIAZOLE DERIVATIVE
PURPOSE:To obtain a 2-amino-4-pyridylmethyl-6-hydroxybenzothiazole derivative useful as an agent for preventing and treating diseases for which a lipoxygenase- inhibiting action is effective, by a new method using an amino- pyridylhydroxymethyl-hydroxybenzothazole derivative as a raw material. CONST...
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| creator | NISHIMURA HIROSHI FURUKAWA TAKESHI KOMATSU TAKEKI MINAMI NORIO YAMAGISHI YOJI |
| description | PURPOSE:To obtain a 2-amino-4-pyridylmethyl-6-hydroxybenzothiazole derivative useful as an agent for preventing and treating diseases for which a lipoxygenase- inhibiting action is effective, by a new method using an amino- pyridylhydroxymethyl-hydroxybenzothazole derivative as a raw material. CONSTITUTION:A 2-amino-4-pyridylhydroxymethyl-6-hydroxybenzothiazole derivative of formula I (R is H, methyl, methoxy; R , R are H, lower alkyl) [e.g. 4-methoxy(3-pyridyl)methyl-6-hydroxy-5,7-dimethyl-2-methylaminobenzoth iazole] is reduced with zinc in acetic acid to obtain the objective compound of formula II. In the reaction, the acetic acid is preferably used in an amount of 1-10 volumes per pt.wt. of the compound of formula I, and the zinc is used in an amount of 2-30 equivalents based on the compound of formula I under refluxing the solvent. The reaction time is usually 6 hrs to 2 days. |
| format | Patent |
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CONSTITUTION:A 2-amino-4-pyridylhydroxymethyl-6-hydroxybenzothiazole derivative of formula I (R is H, methyl, methoxy; R , R are H, lower alkyl) [e.g. 4-methoxy(3-pyridyl)methyl-6-hydroxy-5,7-dimethyl-2-methylaminobenzoth iazole] is reduced with zinc in acetic acid to obtain the objective compound of formula II. In the reaction, the acetic acid is preferably used in an amount of 1-10 volumes per pt.wt. of the compound of formula I, and the zinc is used in an amount of 2-30 equivalents based on the compound of formula I under refluxing the solvent. The reaction time is usually 6 hrs to 2 days.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950221&DB=EPODOC&CC=JP&NR=H0748371A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950221&DB=EPODOC&CC=JP&NR=H0748371A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NISHIMURA HIROSHI</creatorcontrib><creatorcontrib>FURUKAWA TAKESHI</creatorcontrib><creatorcontrib>KOMATSU TAKEKI</creatorcontrib><creatorcontrib>MINAMI NORIO</creatorcontrib><creatorcontrib>YAMAGISHI YOJI</creatorcontrib><title>PRODUCTION OF 2-AMINO-4-PYRIDYLMETHYL-6 HYDROXYBENZOTHIAZOLE DERIVATIVE</title><description>PURPOSE:To obtain a 2-amino-4-pyridylmethyl-6-hydroxybenzothiazole derivative useful as an agent for preventing and treating diseases for which a lipoxygenase- inhibiting action is effective, by a new method using an amino- pyridylhydroxymethyl-hydroxybenzothazole derivative as a raw material. CONSTITUTION:A 2-amino-4-pyridylhydroxymethyl-6-hydroxybenzothiazole derivative of formula I (R is H, methyl, methoxy; R , R are H, lower alkyl) [e.g. 4-methoxy(3-pyridyl)methyl-6-hydroxy-5,7-dimethyl-2-methylaminobenzoth iazole] is reduced with zinc in acetic acid to obtain the objective compound of formula II. In the reaction, the acetic acid is preferably used in an amount of 1-10 volumes per pt.wt. of the compound of formula I, and the zinc is used in an amount of 2-30 equivalents based on the compound of formula I under refluxing the solvent. The reaction time is usually 6 hrs to 2 days.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1995</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHAPCPJ3CXUO8fT3U_B3UzDSdfT19PPXNdENiAzydIn08XUN8Yj00TVT8Ih0CfKPiHRy9YvyD_HwdIzy93FVcHEN8gxzDPEMc-VhYE1LzClO5YXS3AwKbq4hzh66qQX58anFBYnJqXmpJfFeAR4G5iYWxuaGjsZEKAEAwCks8g</recordid><startdate>19950221</startdate><enddate>19950221</enddate><creator>NISHIMURA HIROSHI</creator><creator>FURUKAWA TAKESHI</creator><creator>KOMATSU TAKEKI</creator><creator>MINAMI NORIO</creator><creator>YAMAGISHI YOJI</creator><scope>EVB</scope></search><sort><creationdate>19950221</creationdate><title>PRODUCTION OF 2-AMINO-4-PYRIDYLMETHYL-6 HYDROXYBENZOTHIAZOLE DERIVATIVE</title><author>NISHIMURA HIROSHI ; FURUKAWA TAKESHI ; KOMATSU TAKEKI ; MINAMI NORIO ; YAMAGISHI YOJI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH0748371A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1995</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>NISHIMURA HIROSHI</creatorcontrib><creatorcontrib>FURUKAWA TAKESHI</creatorcontrib><creatorcontrib>KOMATSU TAKEKI</creatorcontrib><creatorcontrib>MINAMI NORIO</creatorcontrib><creatorcontrib>YAMAGISHI YOJI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NISHIMURA HIROSHI</au><au>FURUKAWA TAKESHI</au><au>KOMATSU TAKEKI</au><au>MINAMI NORIO</au><au>YAMAGISHI YOJI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PRODUCTION OF 2-AMINO-4-PYRIDYLMETHYL-6 HYDROXYBENZOTHIAZOLE DERIVATIVE</title><date>1995-02-21</date><risdate>1995</risdate><abstract>PURPOSE:To obtain a 2-amino-4-pyridylmethyl-6-hydroxybenzothiazole derivative useful as an agent for preventing and treating diseases for which a lipoxygenase- inhibiting action is effective, by a new method using an amino- pyridylhydroxymethyl-hydroxybenzothazole derivative as a raw material. CONSTITUTION:A 2-amino-4-pyridylhydroxymethyl-6-hydroxybenzothiazole derivative of formula I (R is H, methyl, methoxy; R , R are H, lower alkyl) [e.g. 4-methoxy(3-pyridyl)methyl-6-hydroxy-5,7-dimethyl-2-methylaminobenzoth iazole] is reduced with zinc in acetic acid to obtain the objective compound of formula II. In the reaction, the acetic acid is preferably used in an amount of 1-10 volumes per pt.wt. of the compound of formula I, and the zinc is used in an amount of 2-30 equivalents based on the compound of formula I under refluxing the solvent. The reaction time is usually 6 hrs to 2 days.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PRODUCTION OF 2-AMINO-4-PYRIDYLMETHYL-6 HYDROXYBENZOTHIAZOLE DERIVATIVE |
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