PYRIDAZINONE DERIVATIVE
PURPOSE:To obtain a new derivative effective to prophylaxis or treatment of various thrombotic diseases, having a potent and a wide range spectrum of inhibiting platelet coagulation, and a low incidence of adverse effects with a superior selectivity in its action. CONSTITUTION:This derivative (salt)...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | MATSUMOTO HIROO MATSUMOTO TAKASHI NAKABEPPU HITOSHI TSURUZOE NOBUTOMO TANIGAWA KEIZO |
| description | PURPOSE:To obtain a new derivative effective to prophylaxis or treatment of various thrombotic diseases, having a potent and a wide range spectrum of inhibiting platelet coagulation, and a low incidence of adverse effects with a superior selectivity in its action. CONSTITUTION:This derivative (salt) is expressed by formula I [R is H, a 1-4C alkyl; X is H, Cl or Br; Ar is a pyridyl or a substituted phenyl; Y is a substituted 1-4C alkylene; each one of Z and Z is H, a halogen, a 1-4 alkyl, etc.], e.g. 4-bromo-6-[3-(4chlorophenyl)-3-hydroxypropyloxy]-5-(3- pyridylmethylamino)-3 (2H) pyridazinone. The above mentioned derivative (salt) is obtained by e.g. reacting 5-halo-3 (2H)-pyridazinone compound of formula II (X is Cl or Br) with an arylmethylamine derivative (salt) of formula III in the presence of a hydrogen halogenate eliminating agent if necessary, in an inactive solvent. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JPH07252237A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JPH07252237A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JPH07252237A3</originalsourceid><addsrcrecordid>eNrjZBAPiAzydHGM8vTz93NVcHEN8gxzDPEMc-VhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfFeAR4G5kamRkbG5o7GxKgBAPWDH-c</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PYRIDAZINONE DERIVATIVE</title><source>esp@cenet</source><creator>MATSUMOTO HIROO ; MATSUMOTO TAKASHI ; NAKABEPPU HITOSHI ; TSURUZOE NOBUTOMO ; TANIGAWA KEIZO</creator><creatorcontrib>MATSUMOTO HIROO ; MATSUMOTO TAKASHI ; NAKABEPPU HITOSHI ; TSURUZOE NOBUTOMO ; TANIGAWA KEIZO</creatorcontrib><description>PURPOSE:To obtain a new derivative effective to prophylaxis or treatment of various thrombotic diseases, having a potent and a wide range spectrum of inhibiting platelet coagulation, and a low incidence of adverse effects with a superior selectivity in its action. CONSTITUTION:This derivative (salt) is expressed by formula I [R is H, a 1-4C alkyl; X is H, Cl or Br; Ar is a pyridyl or a substituted phenyl; Y is a substituted 1-4C alkylene; each one of Z and Z is H, a halogen, a 1-4 alkyl, etc.], e.g. 4-bromo-6-[3-(4chlorophenyl)-3-hydroxypropyloxy]-5-(3- pyridylmethylamino)-3 (2H) pyridazinone. The above mentioned derivative (salt) is obtained by e.g. reacting 5-halo-3 (2H)-pyridazinone compound of formula II (X is Cl or Br) with an arylmethylamine derivative (salt) of formula III in the presence of a hydrogen halogenate eliminating agent if necessary, in an inactive solvent.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951003&DB=EPODOC&CC=JP&NR=H07252237A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19951003&DB=EPODOC&CC=JP&NR=H07252237A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MATSUMOTO HIROO</creatorcontrib><creatorcontrib>MATSUMOTO TAKASHI</creatorcontrib><creatorcontrib>NAKABEPPU HITOSHI</creatorcontrib><creatorcontrib>TSURUZOE NOBUTOMO</creatorcontrib><creatorcontrib>TANIGAWA KEIZO</creatorcontrib><title>PYRIDAZINONE DERIVATIVE</title><description>PURPOSE:To obtain a new derivative effective to prophylaxis or treatment of various thrombotic diseases, having a potent and a wide range spectrum of inhibiting platelet coagulation, and a low incidence of adverse effects with a superior selectivity in its action. CONSTITUTION:This derivative (salt) is expressed by formula I [R is H, a 1-4C alkyl; X is H, Cl or Br; Ar is a pyridyl or a substituted phenyl; Y is a substituted 1-4C alkylene; each one of Z and Z is H, a halogen, a 1-4 alkyl, etc.], e.g. 4-bromo-6-[3-(4chlorophenyl)-3-hydroxypropyloxy]-5-(3- pyridylmethylamino)-3 (2H) pyridazinone. The above mentioned derivative (salt) is obtained by e.g. reacting 5-halo-3 (2H)-pyridazinone compound of formula II (X is Cl or Br) with an arylmethylamine derivative (salt) of formula III in the presence of a hydrogen halogenate eliminating agent if necessary, in an inactive solvent.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1995</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAPiAzydHGM8vTz93NVcHEN8gxzDPEMc-VhYE1LzClO5YXS3AyKbq4hzh66qQX58anFBYnJqXmpJfFeAR4G5kamRkbG5o7GxKgBAPWDH-c</recordid><startdate>19951003</startdate><enddate>19951003</enddate><creator>MATSUMOTO HIROO</creator><creator>MATSUMOTO TAKASHI</creator><creator>NAKABEPPU HITOSHI</creator><creator>TSURUZOE NOBUTOMO</creator><creator>TANIGAWA KEIZO</creator><scope>EVB</scope></search><sort><creationdate>19951003</creationdate><title>PYRIDAZINONE DERIVATIVE</title><author>MATSUMOTO HIROO ; MATSUMOTO TAKASHI ; NAKABEPPU HITOSHI ; TSURUZOE NOBUTOMO ; TANIGAWA KEIZO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH07252237A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1995</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MATSUMOTO HIROO</creatorcontrib><creatorcontrib>MATSUMOTO TAKASHI</creatorcontrib><creatorcontrib>NAKABEPPU HITOSHI</creatorcontrib><creatorcontrib>TSURUZOE NOBUTOMO</creatorcontrib><creatorcontrib>TANIGAWA KEIZO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MATSUMOTO HIROO</au><au>MATSUMOTO TAKASHI</au><au>NAKABEPPU HITOSHI</au><au>TSURUZOE NOBUTOMO</au><au>TANIGAWA KEIZO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRIDAZINONE DERIVATIVE</title><date>1995-10-03</date><risdate>1995</risdate><abstract>PURPOSE:To obtain a new derivative effective to prophylaxis or treatment of various thrombotic diseases, having a potent and a wide range spectrum of inhibiting platelet coagulation, and a low incidence of adverse effects with a superior selectivity in its action. CONSTITUTION:This derivative (salt) is expressed by formula I [R is H, a 1-4C alkyl; X is H, Cl or Br; Ar is a pyridyl or a substituted phenyl; Y is a substituted 1-4C alkylene; each one of Z and Z is H, a halogen, a 1-4 alkyl, etc.], e.g. 4-bromo-6-[3-(4chlorophenyl)-3-hydroxypropyloxy]-5-(3- pyridylmethylamino)-3 (2H) pyridazinone. The above mentioned derivative (salt) is obtained by e.g. reacting 5-halo-3 (2H)-pyridazinone compound of formula II (X is Cl or Br) with an arylmethylamine derivative (salt) of formula III in the presence of a hydrogen halogenate eliminating agent if necessary, in an inactive solvent.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_JPH07252237A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRIDAZINONE DERIVATIVE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T00%3A33%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=MATSUMOTO%20HIROO&rft.date=1995-10-03&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EJPH07252237A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |