PYRAZOLE DERIVATIVE
PURPOSE:To obtain a new derivative useful as an antagonist for angiotensin II in treatment for cardiovascular diseases, especially hypertension, heart failure and vein failure, glaucoma, diabetic retinopathy, central nervous diseases and chronic renal diseases. CONSTITUTION:This compound is represen...
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| creator | MASUDA YUKINORI SATO MASAYUKI TANIGAWA KEIZO KAMIKAWAJI KAMIKAWAJI OODOI KEISUKE HIGASHIYAMA TSUTOMU |
| description | PURPOSE:To obtain a new derivative useful as an antagonist for angiotensin II in treatment for cardiovascular diseases, especially hypertension, heart failure and vein failure, glaucoma, diabetic retinopathy, central nervous diseases and chronic renal diseases. CONSTITUTION:This compound is represented by formula I[R is H, a 1-10C (substituted)-alkyl, etc.; R to R each is a halogen, nitro, etc.; R is carboxyl, 5-tetrazolyl, etc.; X is N or NO; Y and Z each is N or CR ; A and E each IS methylene, etc.; D IS phenyl, etc.; G is a covalent bond, etc.], its tautomer and salt thereof, e.g. N-[1-(2-phenylethyl)-4-ethoxycarbonyl-5-bromopyrazol-3-yl]- N[(2'-(N-triphenylmethyl-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]-n-propylamine. The compound of formula 1 (R' is H) is obtained by reacting, e.g., a compound of formula II with a compound of formula III (V is a halogen, etc.) to lead to a compound of formula IV and as necessary, carrying out deprotection of the compound of formula IV. |
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CONSTITUTION:This compound is represented by formula I[R is H, a 1-10C (substituted)-alkyl, etc.; R to R each is a halogen, nitro, etc.; R is carboxyl, 5-tetrazolyl, etc.; X is N or NO; Y and Z each is N or CR ; A and E each IS methylene, etc.; D IS phenyl, etc.; G is a covalent bond, etc.], its tautomer and salt thereof, e.g. N-[1-(2-phenylethyl)-4-ethoxycarbonyl-5-bromopyrazol-3-yl]- N[(2'-(N-triphenylmethyl-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]-n-propylamine. The compound of formula 1 (R' is H) is obtained by reacting, e.g., a compound of formula II with a compound of formula III (V is a halogen, etc.) to lead to a compound of formula IV and as necessary, carrying out deprotection of the compound of formula IV.</description><edition>6</edition><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; DERIVATIVES THEREOF ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SUGARS</subject><creationdate>1995</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950912&DB=EPODOC&CC=JP&NR=H07238081A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19950912&DB=EPODOC&CC=JP&NR=H07238081A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MASUDA YUKINORI</creatorcontrib><creatorcontrib>SATO MASAYUKI</creatorcontrib><creatorcontrib>TANIGAWA KEIZO</creatorcontrib><creatorcontrib>KAMIKAWAJI KAMIKAWAJI</creatorcontrib><creatorcontrib>OODOI KEISUKE</creatorcontrib><creatorcontrib>HIGASHIYAMA TSUTOMU</creatorcontrib><title>PYRAZOLE DERIVATIVE</title><description>PURPOSE:To obtain a new derivative useful as an antagonist for angiotensin II in treatment for cardiovascular diseases, especially hypertension, heart failure and vein failure, glaucoma, diabetic retinopathy, central nervous diseases and chronic renal diseases. CONSTITUTION:This compound is represented by formula I[R is H, a 1-10C (substituted)-alkyl, etc.; R to R each is a halogen, nitro, etc.; R is carboxyl, 5-tetrazolyl, etc.; X is N or NO; Y and Z each is N or CR ; A and E each IS methylene, etc.; D IS phenyl, etc.; G is a covalent bond, etc.], its tautomer and salt thereof, e.g. N-[1-(2-phenylethyl)-4-ethoxycarbonyl-5-bromopyrazol-3-yl]- N[(2'-(N-triphenylmethyl-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]-n-propylamine. The compound of formula 1 (R' is H) is obtained by reacting, e.g., a compound of formula II with a compound of formula III (V is a halogen, etc.) to lead to a compound of formula IV and as necessary, carrying out deprotection of the compound of formula IV.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1995</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBAOiAxyjPL3cVVwcQ3yDHMM8Qxz5WFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8V4BHgbmRsYWBhaGjsbEqAEAdWEevw</recordid><startdate>19950912</startdate><enddate>19950912</enddate><creator>MASUDA YUKINORI</creator><creator>SATO MASAYUKI</creator><creator>TANIGAWA KEIZO</creator><creator>KAMIKAWAJI KAMIKAWAJI</creator><creator>OODOI KEISUKE</creator><creator>HIGASHIYAMA TSUTOMU</creator><scope>EVB</scope></search><sort><creationdate>19950912</creationdate><title>PYRAZOLE DERIVATIVE</title><author>MASUDA YUKINORI ; SATO MASAYUKI ; TANIGAWA KEIZO ; KAMIKAWAJI KAMIKAWAJI ; OODOI KEISUKE ; HIGASHIYAMA TSUTOMU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH07238081A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1995</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>MASUDA YUKINORI</creatorcontrib><creatorcontrib>SATO MASAYUKI</creatorcontrib><creatorcontrib>TANIGAWA KEIZO</creatorcontrib><creatorcontrib>KAMIKAWAJI KAMIKAWAJI</creatorcontrib><creatorcontrib>OODOI KEISUKE</creatorcontrib><creatorcontrib>HIGASHIYAMA TSUTOMU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MASUDA YUKINORI</au><au>SATO MASAYUKI</au><au>TANIGAWA KEIZO</au><au>KAMIKAWAJI KAMIKAWAJI</au><au>OODOI KEISUKE</au><au>HIGASHIYAMA TSUTOMU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PYRAZOLE DERIVATIVE</title><date>1995-09-12</date><risdate>1995</risdate><abstract>PURPOSE:To obtain a new derivative useful as an antagonist for angiotensin II in treatment for cardiovascular diseases, especially hypertension, heart failure and vein failure, glaucoma, diabetic retinopathy, central nervous diseases and chronic renal diseases. CONSTITUTION:This compound is represented by formula I[R is H, a 1-10C (substituted)-alkyl, etc.; R to R each is a halogen, nitro, etc.; R is carboxyl, 5-tetrazolyl, etc.; X is N or NO; Y and Z each is N or CR ; A and E each IS methylene, etc.; D IS phenyl, etc.; G is a covalent bond, etc.], its tautomer and salt thereof, e.g. N-[1-(2-phenylethyl)-4-ethoxycarbonyl-5-bromopyrazol-3-yl]- N[(2'-(N-triphenylmethyl-(1H-tetrazol-5-yl) biphenyl-4-yl)methyl]-n-propylamine. The compound of formula 1 (R' is H) is obtained by reacting, e.g., a compound of formula II with a compound of formula III (V is a halogen, etc.) to lead to a compound of formula IV and as necessary, carrying out deprotection of the compound of formula IV.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | PYRAZOLE DERIVATIVE |
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