COMPOSITION FOR TREATMENT OF TRICHOPHYTOSIS UNGUIUM

PURPOSE:To obtain a composition for the treatment of trichophytosis unguium, exhibiting excellent adhesivity and penetrability of the drug component to the horny layer of nail and having high storability. CONSTITUTION:This composition for the treatment of trichophytosis unguium is produced by prepar...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: NAKAGAWA AKIRA, MIYATA SATORU, SAKAI KENZO
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:PURPOSE:To obtain a composition for the treatment of trichophytosis unguium, exhibiting excellent adhesivity and penetrability of the drug component to the horny layer of nail and having high storability. CONSTITUTION:This composition for the treatment of trichophytosis unguium is produced by preparing a base agent containing (A) a hydrophobic film-forming agent, preferably pyroxylin (nitrocellulose wet with isopropanol or other proper solvent), (B) a fatty acid ester such as diisopropyl sebacate, diethyl sebacate and diisopropyl adipate and (C) a solvent such as ethyl acetate, acetone, ethanol, isopropanol and xylene and compounding the base agent with (D) an antimycotic agent, preferably omoconazole nitrate or butenafine hydrochloride having high penetrability to horny layer and excellent storability in horny layer. The amount of each component in the composition is 0.3-5wt.% (preferably 0.5-3wt.%) for the component D, 0.5-35wt.% for A, 0.2-20wt.% for B and 20-90wt.% for C.