JPH0643341B

PURPOSE:A drug for improving organ function in organ transplantation, comprising a polypeptide having substantially the same amino acid sequence as that of human superoxide dismutase as an active ingredient. CONSTITUTION:An organ function improver comprising a polypeptide having substantially the same amino acid sequence as that of human superoxide dismutase as an active ingredient. The polypeptide, for example, can be obtained by cultivating a bacterium which is transformed with recombinant DNA containing a human copper, zinc type superoxide dismutase at the downstream of a phenotypic expression control gene having a positive regulation site and by collecting a human copper, zinc type super oxide dismutase accumulated in a culture mixture. The polypeptide is used for preserving an organ extracted from an organism as it is in a living state or injected into an organism to improve organ functions and can be prepared into injection, tablet, ointment, capsule, liposome preparation, etc.