4-HYDROXY-2'-NITROBUTYROPHENONE AND TETRAHYDRO-2-(O-NITROPHENYL)-2-FURANOL
The following are claimed: A) 4-hydroxy-2'-nitrobutyrophenone (I); B) tetrahydro-2-(o-nitrophenyl)-2-furanol (II): and C) prepn. of 4-halo-2'-nitrobutyrophenone of formula (III) comprising reacting a cpd. of formula (IV) with a 2-haloethanol cpd. of formula (V) in the presence of an aq. ba...
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| creator | DEIBITSUDO ANDORESU KOOTESU |
| description | The following are claimed: A) 4-hydroxy-2'-nitrobutyrophenone (I); B) tetrahydro-2-(o-nitrophenyl)-2-furanol (II): and C) prepn. of 4-halo-2'-nitrobutyrophenone of formula (III) comprising reacting a cpd. of formula (IV) with a 2-haloethanol cpd. of formula (V) in the presence of an aq. base and a phase transfer catalyst, opt. in the presence of an organic solvent to form (I) and/or (II), and further reacting (I) and/or (II) with a hydrogen halide to form (III). X' = halo; R = 1-4C alkyl X" = Cl or Br. The hydrogen halide is used as an excess amt. and is HCl or HBr. The solvent is water and/or an aromatic hydrocarbon such as toluene. The reaction temp. is 40-130 deg.C. One molar equiv. of the 2-haloethanol cpd. is used. The phase transfer catalyst is benzyltrimethylammonium hydroxide and the aq. base is NaOH. (I) and/or (II) can be prepd. by reacting dihydro-3-(o-nitrobenzoyl)-2(3H)-furanone with an aq. acid selected from sulphuric acid, phosphoric acid and acetic acid, opt. in the presence of an organic solvent. |
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X' = halo; R = 1-4C alkyl X" = Cl or Br. The hydrogen halide is used as an excess amt. and is HCl or HBr. The solvent is water and/or an aromatic hydrocarbon such as toluene. The reaction temp. is 40-130 deg.C. One molar equiv. of the 2-haloethanol cpd. is used. The phase transfer catalyst is benzyltrimethylammonium hydroxide and the aq. base is NaOH. (I) and/or (II) can be prepd. by reacting dihydro-3-(o-nitrobenzoyl)-2(3H)-furanone with an aq. acid selected from sulphuric acid, phosphoric acid and acetic acid, opt. in the presence of an organic solvent.</description><edition>5</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1994</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940719&DB=EPODOC&CC=JP&NR=H06199742A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19940719&DB=EPODOC&CC=JP&NR=H06199742A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>DEIBITSUDO ANDORESU KOOTESU</creatorcontrib><title>4-HYDROXY-2'-NITROBUTYROPHENONE AND TETRAHYDRO-2-(O-NITROPHENYL)-2-FURANOL</title><description>The following are claimed: A) 4-hydroxy-2'-nitrobutyrophenone (I); B) tetrahydro-2-(o-nitrophenyl)-2-furanol (II): and C) prepn. of 4-halo-2'-nitrobutyrophenone of formula (III) comprising reacting a cpd. of formula (IV) with a 2-haloethanol cpd. of formula (V) in the presence of an aq. base and a phase transfer catalyst, opt. in the presence of an organic solvent to form (I) and/or (II), and further reacting (I) and/or (II) with a hydrogen halide to form (III). X' = halo; R = 1-4C alkyl X" = Cl or Br. The hydrogen halide is used as an excess amt. and is HCl or HBr. The solvent is water and/or an aromatic hydrocarbon such as toluene. The reaction temp. is 40-130 deg.C. One molar equiv. of the 2-haloethanol cpd. is used. The phase transfer catalyst is benzyltrimethylammonium hydroxide and the aq. base is NaOH. (I) and/or (II) can be prepd. by reacting dihydro-3-(o-nitrobenzoyl)-2(3H)-furanone with an aq. acid selected from sulphuric acid, phosphoric acid and acetic acid, opt. in the presence of an organic solvent.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1994</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZPAy0fWIdAnyj4jUNVLX9fMMCfJ3Cg2JDPIP8HD18_dzVXD0c1EIcQ0JcgQr0zXS1fCHKAMpiPTRBIq4hQY5-vn78DCwpiXmFKfyQmluBkU31xBnD93Ugvz41OKCxOTUvNSSeK8ADwMzQ0tLcxMjR2Ni1AAAbystuQ</recordid><startdate>19940719</startdate><enddate>19940719</enddate><creator>DEIBITSUDO ANDORESU KOOTESU</creator><scope>EVB</scope></search><sort><creationdate>19940719</creationdate><title>4-HYDROXY-2'-NITROBUTYROPHENONE AND TETRAHYDRO-2-(O-NITROPHENYL)-2-FURANOL</title><author>DEIBITSUDO ANDORESU KOOTESU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH06199742A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1994</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>DEIBITSUDO ANDORESU KOOTESU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>DEIBITSUDO ANDORESU KOOTESU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>4-HYDROXY-2'-NITROBUTYROPHENONE AND TETRAHYDRO-2-(O-NITROPHENYL)-2-FURANOL</title><date>1994-07-19</date><risdate>1994</risdate><abstract>The following are claimed: A) 4-hydroxy-2'-nitrobutyrophenone (I); B) tetrahydro-2-(o-nitrophenyl)-2-furanol (II): and C) prepn. of 4-halo-2'-nitrobutyrophenone of formula (III) comprising reacting a cpd. of formula (IV) with a 2-haloethanol cpd. of formula (V) in the presence of an aq. base and a phase transfer catalyst, opt. in the presence of an organic solvent to form (I) and/or (II), and further reacting (I) and/or (II) with a hydrogen halide to form (III). X' = halo; R = 1-4C alkyl X" = Cl or Br. The hydrogen halide is used as an excess amt. and is HCl or HBr. The solvent is water and/or an aromatic hydrocarbon such as toluene. The reaction temp. is 40-130 deg.C. One molar equiv. of the 2-haloethanol cpd. is used. The phase transfer catalyst is benzyltrimethylammonium hydroxide and the aq. base is NaOH. (I) and/or (II) can be prepd. by reacting dihydro-3-(o-nitrobenzoyl)-2(3H)-furanone with an aq. acid selected from sulphuric acid, phosphoric acid and acetic acid, opt. in the presence of an organic solvent.</abstract><edition>5</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | 4-HYDROXY-2'-NITROBUTYROPHENONE AND TETRAHYDRO-2-(O-NITROPHENYL)-2-FURANOL |
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