7H-PYRIDO(3,2,1-IJ) (2,1)BENZOXAZINE DERIVATIVE
NEW MATERIAL:The compound of formula I [X is N-substituted 5- to 7-membered saturated cyclic amine which may contain hetero atom or may be substituted with lower alkyl(amino), amino, acetylamino or OH]. EXAMPLE:9-Fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-1,2-dihydro-7H-pyri do[3,2,1- ij][2,1]benzoxaz...
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| creator | WATABE MAYUMI SAKAE MASATOSHI HASE MASAFUMI SABATO TAKAAKI KATSURADA MASANORI OTSUBO EMIKO NISHIGAKI SADAO |
| description | NEW MATERIAL:The compound of formula I [X is N-substituted 5- to 7-membered saturated cyclic amine which may contain hetero atom or may be substituted with lower alkyl(amino), amino, acetylamino or OH]. EXAMPLE:9-Fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-1,2-dihydro-7H-pyri do[3,2,1- ij][2,1]benzoxazine-6-carboxylic acid. USE:Antibacterial agent against Gram-negative bacteria and Gram-positive bacteria. PREPARATION:The objective compound can be produced by reacting 9,10- difluoro-7-oxo-1,2-dihydro-7H-pyrido[3,2,1-ij][2,1]benzoxazine-6-carbo xylic acid with a saturated cyclic amine of formula XH in an inert solvent (e.g. ethanol) at 70-150 deg.C for 20min to 5hr. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 7H-PYRIDO(3,2,1-IJ) (2,1)BENZOXAZINE DERIVATIVE |
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