7H-PYRIDO(3,2,1-IJ) (2,1)BENZOXAZINE DERIVATIVE

NEW MATERIAL:The compound of formula I [X is N-substituted 5- to 7-membered saturated cyclic amine which may contain hetero atom or may be substituted with lower alkyl(amino), amino, acetylamino or OH]. EXAMPLE:9-Fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-1,2-dihydro-7H-pyri do[3,2,1- ij][2,1]benzoxaz...

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Bibliographische Detailangaben
Hauptverfasser:	WATABE MAYUMI, SAKAE MASATOSHI, HASE MASAFUMI, SABATO TAKAAKI, KATSURADA MASANORI, OTSUBO EMIKO, NISHIGAKI SADAO
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	NEW MATERIAL:The compound of formula I [X is N-substituted 5- to 7-membered saturated cyclic amine which may contain hetero atom or may be substituted with lower alkyl(amino), amino, acetylamino or OH]. EXAMPLE:9-Fluoro-10-(4-methyl-1-piperazinyl)-7-oxo-1,2-dihydro-7H-pyri do[3,2,1- ij][2,1]benzoxazine-6-carboxylic acid. USE:Antibacterial agent against Gram-negative bacteria and Gram-positive bacteria. PREPARATION:The objective compound can be produced by reacting 9,10- difluoro-7-oxo-1,2-dihydro-7H-pyrido[3,2,1-ij][2,1]benzoxazine-6-carbo xylic acid with a saturated cyclic amine of formula XH in an inert solvent (e.g. ethanol) at 70-150 deg.C for 20min to 5hr.