7H-PYRIDO(3,2,1-IJ) (2,1)BENZOXAZIEN DERIVATIVE
NEW MATERIAL:The derivative of formula I (R is H or lower alkyl) and its salt. EXAMPLE:9,10-Difluoro-7-oxo-1,2-dihydro-7H-pyrido[3,2,1-ij][2,1]benzox azine-6- carboxylic acid. USE:An intermediate for a compound of formula II (X is N-substituted 5- to 7-membered saturated cyclic amine) useful as a th...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | WATABE MAYUMI SAKAE MASATOSHI SABATO TAKAAKI KATSURADA MASANORI NISHIGAKI SADAO |
| description | NEW MATERIAL:The derivative of formula I (R is H or lower alkyl) and its salt. EXAMPLE:9,10-Difluoro-7-oxo-1,2-dihydro-7H-pyrido[3,2,1-ij][2,1]benzox azine-6- carboxylic acid. USE:An intermediate for a compound of formula II (X is N-substituted 5- to 7-membered saturated cyclic amine) useful as a therapeutic agent for infection with Gram-negative and Gram-positive bacteria. PREPARATION:The objective compound of formula I can be produced by treating a compound of formula III with ethoxymethylenemalonic acid diethyl ester to obtain a compound of formula IV, converting the compound into an OH-protected compound of formula V by treating with acetic anhydride, heating the product together with a polyphosphoric acid ethyl ester, treating the resultant compound of formula VI with a halogenation agent, deprotecting by alkali treatment to obtain a compound of formula VII and treating the compound with an acid to effect intramolecular cyclization reaction. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JPH04208287A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JPH04208287A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JPH04208287A3</originalsourceid><addsrcrecordid>eNrjZNA399ANiAzydPHXMNYx0jHU9fTSVNAAMjSdXP2i_CMcozxd_RRcXIM8wxxDPMNceRhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvFeAh4GJkYGFkYW5ozExagCPBCU4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>7H-PYRIDO(3,2,1-IJ) (2,1)BENZOXAZIEN DERIVATIVE</title><source>esp@cenet</source><creator>WATABE MAYUMI ; SAKAE MASATOSHI ; SABATO TAKAAKI ; KATSURADA MASANORI ; NISHIGAKI SADAO</creator><creatorcontrib>WATABE MAYUMI ; SAKAE MASATOSHI ; SABATO TAKAAKI ; KATSURADA MASANORI ; NISHIGAKI SADAO</creatorcontrib><description>NEW MATERIAL:The derivative of formula I (R is H or lower alkyl) and its salt. EXAMPLE:9,10-Difluoro-7-oxo-1,2-dihydro-7H-pyrido[3,2,1-ij][2,1]benzox azine-6- carboxylic acid. USE:An intermediate for a compound of formula II (X is N-substituted 5- to 7-membered saturated cyclic amine) useful as a therapeutic agent for infection with Gram-negative and Gram-positive bacteria. PREPARATION:The objective compound of formula I can be produced by treating a compound of formula III with ethoxymethylenemalonic acid diethyl ester to obtain a compound of formula IV, converting the compound into an OH-protected compound of formula V by treating with acetic anhydride, heating the product together with a polyphosphoric acid ethyl ester, treating the resultant compound of formula VI with a halogenation agent, deprotecting by alkali treatment to obtain a compound of formula VII and treating the compound with an acid to effect intramolecular cyclization reaction.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1992</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920729&DB=EPODOC&CC=JP&NR=H04208287A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920729&DB=EPODOC&CC=JP&NR=H04208287A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>WATABE MAYUMI</creatorcontrib><creatorcontrib>SAKAE MASATOSHI</creatorcontrib><creatorcontrib>SABATO TAKAAKI</creatorcontrib><creatorcontrib>KATSURADA MASANORI</creatorcontrib><creatorcontrib>NISHIGAKI SADAO</creatorcontrib><title>7H-PYRIDO(3,2,1-IJ) (2,1)BENZOXAZIEN DERIVATIVE</title><description>NEW MATERIAL:The derivative of formula I (R is H or lower alkyl) and its salt. EXAMPLE:9,10-Difluoro-7-oxo-1,2-dihydro-7H-pyrido[3,2,1-ij][2,1]benzox azine-6- carboxylic acid. USE:An intermediate for a compound of formula II (X is N-substituted 5- to 7-membered saturated cyclic amine) useful as a therapeutic agent for infection with Gram-negative and Gram-positive bacteria. PREPARATION:The objective compound of formula I can be produced by treating a compound of formula III with ethoxymethylenemalonic acid diethyl ester to obtain a compound of formula IV, converting the compound into an OH-protected compound of formula V by treating with acetic anhydride, heating the product together with a polyphosphoric acid ethyl ester, treating the resultant compound of formula VI with a halogenation agent, deprotecting by alkali treatment to obtain a compound of formula VII and treating the compound with an acid to effect intramolecular cyclization reaction.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1992</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNA399ANiAzydPHXMNYx0jHU9fTSVNAAMjSdXP2i_CMcozxd_RRcXIM8wxxDPMNceRhY0xJzilN5oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvFeAh4GJkYGFkYW5ozExagCPBCU4</recordid><startdate>19920729</startdate><enddate>19920729</enddate><creator>WATABE MAYUMI</creator><creator>SAKAE MASATOSHI</creator><creator>SABATO TAKAAKI</creator><creator>KATSURADA MASANORI</creator><creator>NISHIGAKI SADAO</creator><scope>EVB</scope></search><sort><creationdate>19920729</creationdate><title>7H-PYRIDO(3,2,1-IJ) (2,1)BENZOXAZIEN DERIVATIVE</title><author>WATABE MAYUMI ; SAKAE MASATOSHI ; SABATO TAKAAKI ; KATSURADA MASANORI ; NISHIGAKI SADAO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH04208287A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1992</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>WATABE MAYUMI</creatorcontrib><creatorcontrib>SAKAE MASATOSHI</creatorcontrib><creatorcontrib>SABATO TAKAAKI</creatorcontrib><creatorcontrib>KATSURADA MASANORI</creatorcontrib><creatorcontrib>NISHIGAKI SADAO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>WATABE MAYUMI</au><au>SAKAE MASATOSHI</au><au>SABATO TAKAAKI</au><au>KATSURADA MASANORI</au><au>NISHIGAKI SADAO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>7H-PYRIDO(3,2,1-IJ) (2,1)BENZOXAZIEN DERIVATIVE</title><date>1992-07-29</date><risdate>1992</risdate><abstract>NEW MATERIAL:The derivative of formula I (R is H or lower alkyl) and its salt. EXAMPLE:9,10-Difluoro-7-oxo-1,2-dihydro-7H-pyrido[3,2,1-ij][2,1]benzox azine-6- carboxylic acid. USE:An intermediate for a compound of formula II (X is N-substituted 5- to 7-membered saturated cyclic amine) useful as a therapeutic agent for infection with Gram-negative and Gram-positive bacteria. PREPARATION:The objective compound of formula I can be produced by treating a compound of formula III with ethoxymethylenemalonic acid diethyl ester to obtain a compound of formula IV, converting the compound into an OH-protected compound of formula V by treating with acetic anhydride, heating the product together with a polyphosphoric acid ethyl ester, treating the resultant compound of formula VI with a halogenation agent, deprotecting by alkali treatment to obtain a compound of formula VII and treating the compound with an acid to effect intramolecular cyclization reaction.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_JPH04208287A |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | 7H-PYRIDO(3,2,1-IJ) (2,1)BENZOXAZIEN DERIVATIVE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-10T15%3A05%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=WATABE%20MAYUMI&rft.date=1992-07-29&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EJPH04208287A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |