PRODUCTION OF 1,6-DI(N-P-CHLOROPHENYLBIGUANIDE)-HEXANE
PURPOSE:To obtain the subject compound in high yield and purity by adding 1,6-di(N-p-chlorophenylbiguanide)hexane dihydrochloride to a (hydrated) lower alcohol and neutralizing with a specific amount of an alkali metal hydroxide (or its aqueous solution) under refluxing. CONSTITUTION:The objective 1...
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| creator | IGARASHI RENSUKE SASAKI TOMOKI NAKAMURA AKIRA |
| description | PURPOSE:To obtain the subject compound in high yield and purity by adding 1,6-di(N-p-chlorophenylbiguanide)hexane dihydrochloride to a (hydrated) lower alcohol and neutralizing with a specific amount of an alkali metal hydroxide (or its aqueous solution) under refluxing. CONSTITUTION:The objective 1,6-di(N-p-chlorophenylbiguanide)hexane is produced by adding 1,6-di(N-p-chlorophenylbiguanide)hexane dihydrochloride to a (water-containing) lower alcohol and adding >=1.8mol, preferably 1.8-3mol (based on 1mol of the dihydrochloride) of an alkali metal hydroxide or its aqueous solution to the above mixture under refluxing. The alcohol concentration of the lower alcohol is preferably 40-95wt.%. The process is industrially advantageous. The product is useful as an antibacterial agent extremely effective to Grampositive and Gram-negative bacteria and as an antiseptic agent. |
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CONSTITUTION:The objective 1,6-di(N-p-chlorophenylbiguanide)hexane is produced by adding 1,6-di(N-p-chlorophenylbiguanide)hexane dihydrochloride to a (water-containing) lower alcohol and adding >=1.8mol, preferably 1.8-3mol (based on 1mol of the dihydrochloride) of an alkali metal hydroxide or its aqueous solution to the above mixture under refluxing. The alcohol concentration of the lower alcohol is preferably 40-95wt.%. The process is industrially advantageous. 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CONSTITUTION:The objective 1,6-di(N-p-chlorophenylbiguanide)hexane is produced by adding 1,6-di(N-p-chlorophenylbiguanide)hexane dihydrochloride to a (water-containing) lower alcohol and adding >=1.8mol, preferably 1.8-3mol (based on 1mol of the dihydrochloride) of an alkali metal hydroxide or its aqueous solution to the above mixture under refluxing. The alcohol concentration of the lower alcohol is preferably 40-95wt.%. The process is industrially advantageous. 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CONSTITUTION:The objective 1,6-di(N-p-chlorophenylbiguanide)hexane is produced by adding 1,6-di(N-p-chlorophenylbiguanide)hexane dihydrochloride to a (water-containing) lower alcohol and adding >=1.8mol, preferably 1.8-3mol (based on 1mol of the dihydrochloride) of an alkali metal hydroxide or its aqueous solution to the above mixture under refluxing. The alcohol concentration of the lower alcohol is preferably 40-95wt.%. The process is industrially advantageous. The product is useful as an antibacterial agent extremely effective to Grampositive and Gram-negative bacteria and as an antiseptic agent.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | PRODUCTION OF 1,6-DI(N-P-CHLOROPHENYLBIGUANIDE)-HEXANE |
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