PRODUCTION OF PHENYLMALONIC ACID MONOANILIDE DERIVATIVE AND 3-PHENYL-2-QUINOLONE DERIVATIVE
NEW MATERIAL:The compound of formula I (X and Y are H or 1-3C alkoxy; Z is 1-3C alkoxy). EXAMPLE:2-(3-Methoxy-phenylcarbamoyl)-2-(2,4-dimethoxyphenyl)acetic acid. USE:Useful as a drug or its synthetic intermediate. PREPARATION:The compound of formula I is produced by reacting an aniline derivative o...
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| creator | HIRATA KAZUMITSU KAMIJO TETSUKIYO TSUBAKI ATSUSHI YAMAGUCHI TOSHIAKI |
| description | NEW MATERIAL:The compound of formula I (X and Y are H or 1-3C alkoxy; Z is 1-3C alkoxy). EXAMPLE:2-(3-Methoxy-phenylcarbamoyl)-2-(2,4-dimethoxyphenyl)acetic acid. USE:Useful as a drug or its synthetic intermediate. PREPARATION:The compound of formula I is produced by reacting an aniline derivative of formula II with a phenylmalonic acid monoester derivative of formula III (R is lower alkyl) in the presence of a dehydrative condensation agent (e.g. trimethylsilyl phosphite) at room temperature and removing the ester group of the product. Cyclization of the compound of formula I in the presence of a condensation agent gives a 3-phenyl-2-quinolone derivative of formula IV exhibiting osteogenesis promoting action and useful as a remedy for osteoporosis. |
| format | Patent |
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EXAMPLE:2-(3-Methoxy-phenylcarbamoyl)-2-(2,4-dimethoxyphenyl)acetic acid. USE:Useful as a drug or its synthetic intermediate. PREPARATION:The compound of formula I is produced by reacting an aniline derivative of formula II with a phenylmalonic acid monoester derivative of formula III (R is lower alkyl) in the presence of a dehydrative condensation agent (e.g. trimethylsilyl phosphite) at room temperature and removing the ester group of the product. Cyclization of the compound of formula I in the presence of a condensation agent gives a 3-phenyl-2-quinolone derivative of formula IV exhibiting osteogenesis promoting action and useful as a remedy for osteoporosis.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1991</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910201&DB=EPODOC&CC=JP&NR=H0324047A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19910201&DB=EPODOC&CC=JP&NR=H0324047A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>HIRATA KAZUMITSU</creatorcontrib><creatorcontrib>KAMIJO TETSUKIYO</creatorcontrib><creatorcontrib>TSUBAKI ATSUSHI</creatorcontrib><creatorcontrib>YAMAGUCHI TOSHIAKI</creatorcontrib><title>PRODUCTION OF PHENYLMALONIC ACID MONOANILIDE DERIVATIVE AND 3-PHENYL-2-QUINOLONE DERIVATIVE</title><description>NEW MATERIAL:The compound of formula I (X and Y are H or 1-3C alkoxy; Z is 1-3C alkoxy). EXAMPLE:2-(3-Methoxy-phenylcarbamoyl)-2-(2,4-dimethoxyphenyl)acetic acid. USE:Useful as a drug or its synthetic intermediate. PREPARATION:The compound of formula I is produced by reacting an aniline derivative of formula II with a phenylmalonic acid monoester derivative of formula III (R is lower alkyl) in the presence of a dehydrative condensation agent (e.g. trimethylsilyl phosphite) at room temperature and removing the ester group of the product. Cyclization of the compound of formula I in the presence of a condensation agent gives a 3-phenyl-2-quinolone derivative of formula IV exhibiting osteogenesis promoting action and useful as a remedy for osteoporosis.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1991</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIgOCPJ3CXUO8fT3U_B3UwjwcPWL9PF19PH383RWcHT2dFHw9ffzd_Tz9PF0cVVwcQ3yDHMM8QxzVXD0c1Ew1oWo1zXSDQz19PMH6kJWw8PAmpaYU5zKC6W5GRTcXEOcPXRTC_LjU4sLEpNT81JL4r0CPAyMjUwMTMwdjYlQAgA2tzHo</recordid><startdate>19910201</startdate><enddate>19910201</enddate><creator>HIRATA KAZUMITSU</creator><creator>KAMIJO TETSUKIYO</creator><creator>TSUBAKI ATSUSHI</creator><creator>YAMAGUCHI TOSHIAKI</creator><scope>EVB</scope></search><sort><creationdate>19910201</creationdate><title>PRODUCTION OF PHENYLMALONIC ACID MONOANILIDE DERIVATIVE AND 3-PHENYL-2-QUINOLONE DERIVATIVE</title><author>HIRATA KAZUMITSU ; KAMIJO TETSUKIYO ; TSUBAKI ATSUSHI ; YAMAGUCHI TOSHIAKI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JPH0324047A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1991</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>HIRATA KAZUMITSU</creatorcontrib><creatorcontrib>KAMIJO TETSUKIYO</creatorcontrib><creatorcontrib>TSUBAKI ATSUSHI</creatorcontrib><creatorcontrib>YAMAGUCHI TOSHIAKI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HIRATA KAZUMITSU</au><au>KAMIJO TETSUKIYO</au><au>TSUBAKI ATSUSHI</au><au>YAMAGUCHI TOSHIAKI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PRODUCTION OF PHENYLMALONIC ACID MONOANILIDE DERIVATIVE AND 3-PHENYL-2-QUINOLONE DERIVATIVE</title><date>1991-02-01</date><risdate>1991</risdate><abstract>NEW MATERIAL:The compound of formula I (X and Y are H or 1-3C alkoxy; Z is 1-3C alkoxy). EXAMPLE:2-(3-Methoxy-phenylcarbamoyl)-2-(2,4-dimethoxyphenyl)acetic acid. USE:Useful as a drug or its synthetic intermediate. PREPARATION:The compound of formula I is produced by reacting an aniline derivative of formula II with a phenylmalonic acid monoester derivative of formula III (R is lower alkyl) in the presence of a dehydrative condensation agent (e.g. trimethylsilyl phosphite) at room temperature and removing the ester group of the product. Cyclization of the compound of formula I in the presence of a condensation agent gives a 3-phenyl-2-quinolone derivative of formula IV exhibiting osteogenesis promoting action and useful as a remedy for osteoporosis.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PRODUCTION OF PHENYLMALONIC ACID MONOANILIDE DERIVATIVE AND 3-PHENYL-2-QUINOLONE DERIVATIVE |
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