JPH0310621B

The present invention relates to 4-quinolone derivatives represented by the following general formula (I) and salts thereof, as well as their use as pharmaceuticals and methods for manufacturing them. In the formula, R and R are same or different and they are hydrogen, lower aklyl of one to eight carbon chain length or lower alkenyl of one to four carbon chain length; R stands for hydrogen, lower alkyl of one to eight carbon chain length, lower alkyl of one to eight carbon chain length with one or two hydroxyl group(s), lower alkyl or three to ten carbon chain length with one or two ether bond(s), or-(CH2)nA where n is an integer of 1 to 3 and A is acetyl, acetyloxy, cyano orphenoxy; Z stands for phenyl with or without substituent(s) selected from a group consisting of hydrogen, halogen, lower alkyl of one to eight carbon chain length, lower haloalkyl of one to three carbon chain length, lower alkoxy of one to four carbon chain length and COOR (in which R is hydrogen or lower alkyl of one to four carbon chain length) or Z stands for unsaturated hetero ring radical with five or six members having nitrogen, oxygen or sulfur as hetero atom.