PRODUCTION OF GRANULAR CYSTEAMINE HYDROCHLORIDE

PRODUCTION OF GRANULAR CYSTEAMINE HYDROCHLORIDE

PURPOSE:To obtain granular cysteamine hydrochloride useful as a raw material for drugs and agricultural chemicals in high purity by reacting 2- chloroethylamine hydrochloride with 2-mercaptothiazoline, hydrolyzing, heating and melting, cooling and coagulating. CONSTITUTION:2-Chloroethylamine hydroch...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GOSHIMA YUUJIROU, YOKOYAMA HIROMI, TAMURA AKIRA
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:PURPOSE:To obtain granular cysteamine hydrochloride useful as a raw material for drugs and agricultural chemicals in high purity by reacting 2- chloroethylamine hydrochloride with 2-mercaptothiazoline, hydrolyzing, heating and melting, cooling and coagulating. CONSTITUTION:2-Chloroethylamine hydrochloride is reacted with 2- mercaptothiazoline in a solvent such as benzene to give 2-(2'-aminoethylthio)- thiazolidine hydrochloride. Then this compound is hydrolyzed with hydrochloric acid to give cysteamine hydrochloride. Crystal of cysteamine hydrochloride is heated and melted at >=68 deg.C, then dripped on a corrosion-resistant substrate (e.g. Teflon) cooled to