PENTABROMOPROPENE DERIVATIVE

PENTABROMOPROPENE DERIVATIVE

NEW MATERIAL:A pentabromopropene derivative expressed by formula I (R is tribromomethyl or dibromomethyl). EXAMPLE:Pentabromopropen-2-yl tribromoacetate. USE:A drug, having aldose reductase inhibitory action, useful for preventing and treating diabetic complications and capable of being orally or pa...

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Hauptverfasser: YOSHIOKA SHINJI, HORIKOSHI HIROYOSHI, SATOU AIYA, SUGANO MICHIHIRO, NAGAKI HIDEMI
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:NEW MATERIAL:A pentabromopropene derivative expressed by formula I (R is tribromomethyl or dibromomethyl). EXAMPLE:Pentabromopropen-2-yl tribromoacetate. USE:A drug, having aldose reductase inhibitory action, useful for preventing and treating diabetic complications and capable of being orally or parenterally administered. PREPARATION:Algae, belonging to the genus Asparagopsis of the family Bronnemaisoniaceae and containing a pentabromopropene derivative are isolated. As an alternative method, hexabromoacetone is reacted with a reactive derivative of an organic acid having formula II in an amount of preferably 1-2mol based on 1mol hexabromoacetone in the presence of a metal, preferably zinc to afford the compound expressed by formula I.