JP2993316B
PURPOSE:To provide the novel aminoquinolone derivative inhibiting the multiplication of HIV in a cell infected with the HIV and further suppressing the cell degeneration effect caused by the HIV. CONSTITUTION:The compound of formula I [X is H, halogen; Y is H, halogen, alkyl, amino, mono or dialkyl-...
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| creator | KATSUBE TETSUTSUGU KIMURA TOMIO |
| description | PURPOSE:To provide the novel aminoquinolone derivative inhibiting the multiplication of HIV in a cell infected with the HIV and further suppressing the cell degeneration effect caused by the HIV. CONSTITUTION:The compound of formula I [X is H, halogen; Y is H, halogen, alkyl, amino, mono or dialkyl-substituted amino, etc.; Z is carboxy. 5-tetrazolyl; Q is N, CR (R is alkoxy. alkyl, H, etc.,); R is H, alkyl, aryl. five-six membered heteroaromatic single ring containing one or two of hetero atoms (N, O, S), etc.; R is group of formula II or formula III (R , R are aryl, heteroaromatic single ring containing one or two of N, 0 and S, etc.; R , R , R are H, alkyl; R is H, alkyl, OH, alkoxy; (n) is 1, 2; (m) is 0,1; (n') is 1,2; (n'') is 1-4)], e.g. 1-cyclopropyl-6-fluoro-8-difluoromethoxy-7-[4-(2-merthoxyphenyl) pipeazin-1-ly]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride. |
| format | Patent |
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CONSTITUTION:The compound of formula I [X is H, halogen; Y is H, halogen, alkyl, amino, mono or dialkyl-substituted amino, etc.; Z is carboxy. 5-tetrazolyl; Q is N, CR (R is alkoxy. alkyl, H, etc.,); R is H, alkyl, aryl. five-six membered heteroaromatic single ring containing one or two of hetero atoms (N, O, S), etc.; R is group of formula II or formula III (R , R are aryl, heteroaromatic single ring containing one or two of N, 0 and S, etc.; R , R , R are H, alkyl; R is H, alkyl, OH, alkoxy; (n) is 1, 2; (m) is 0,1; (n') is 1,2; (n'') is 1-4)], e.g. 1-cyclopropyl-6-fluoro-8-difluoromethoxy-7-[4-(2-merthoxyphenyl) pipeazin-1-ly]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride.</description><edition>6</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991220&DB=EPODOC&CC=JP&NR=2993316B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19991220&DB=EPODOC&CC=JP&NR=2993316B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KATSUBE TETSUTSUGU</creatorcontrib><creatorcontrib>KIMURA TOMIO</creatorcontrib><title>JP2993316B</title><description>PURPOSE:To provide the novel aminoquinolone derivative inhibiting the multiplication of HIV in a cell infected with the HIV and further suppressing the cell degeneration effect caused by the HIV. CONSTITUTION:The compound of formula I [X is H, halogen; Y is H, halogen, alkyl, amino, mono or dialkyl-substituted amino, etc.; Z is carboxy. 5-tetrazolyl; Q is N, CR (R is alkoxy. alkyl, H, etc.,); R is H, alkyl, aryl. five-six membered heteroaromatic single ring containing one or two of hetero atoms (N, O, S), etc.; R is group of formula II or formula III (R , R are aryl, heteroaromatic single ring containing one or two of N, 0 and S, etc.; R , R , R are H, alkyl; R is H, alkyl, OH, alkoxy; (n) is 1, 2; (m) is 0,1; (n') is 1,2; (n'') is 1-4)], e.g. 1-cyclopropyl-6-fluoro-8-difluoromethoxy-7-[4-(2-merthoxyphenyl) pipeazin-1-ly]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZODyCjCytDQ2NjRz4mFgTUvMKU7lhdLcDIpuriHOHrqpBfnxqcUFicmpeakl8QgNTkbGxKgBACkkG3w</recordid><startdate>19991220</startdate><enddate>19991220</enddate><creator>KATSUBE TETSUTSUGU</creator><creator>KIMURA TOMIO</creator><scope>EVB</scope></search><sort><creationdate>19991220</creationdate><title>JP2993316B</title><author>KATSUBE TETSUTSUGU ; KIMURA TOMIO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2993316BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1999</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KATSUBE TETSUTSUGU</creatorcontrib><creatorcontrib>KIMURA TOMIO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KATSUBE TETSUTSUGU</au><au>KIMURA TOMIO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>JP2993316B</title><date>1999-12-20</date><risdate>1999</risdate><abstract>PURPOSE:To provide the novel aminoquinolone derivative inhibiting the multiplication of HIV in a cell infected with the HIV and further suppressing the cell degeneration effect caused by the HIV. CONSTITUTION:The compound of formula I [X is H, halogen; Y is H, halogen, alkyl, amino, mono or dialkyl-substituted amino, etc.; Z is carboxy. 5-tetrazolyl; Q is N, CR (R is alkoxy. alkyl, H, etc.,); R is H, alkyl, aryl. five-six membered heteroaromatic single ring containing one or two of hetero atoms (N, O, S), etc.; R is group of formula II or formula III (R , R are aryl, heteroaromatic single ring containing one or two of N, 0 and S, etc.; R , R , R are H, alkyl; R is H, alkyl, OH, alkoxy; (n) is 1, 2; (m) is 0,1; (n') is 1,2; (n'') is 1-4)], e.g. 1-cyclopropyl-6-fluoro-8-difluoromethoxy-7-[4-(2-merthoxyphenyl) pipeazin-1-ly]-1,4-dihydro-4-oxoquinoline-3-carboxylic acid hydrochloride.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | JP2993316B |
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