JP2987313B

Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection: wherein A, B, R1 to R4 and n have the same meanings as defined in the specification. The novel HIV protease inhibitor of the formula (I) has a specific structure to form a stable bondin...

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Hauptverfasser: RI MASANOBU, KIN CHURETSU, KIN SHOSHU, KIN SEITEN, SAI KOJITSU, KO SHOSEI, IN KOSHOKU, BUN MITSUNORI, SAI RAKUKEN, BOKU SHISHO, SON EISAN, TEI MOTOHIRO
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creator RI MASANOBU
KIN CHURETSU
KIN SHOSHU
KIN SEITEN
SAI KOJITSU
KO SHOSEI
IN KOSHOKU
BUN MITSUNORI
SAI RAKUKEN
BOKU SHISHO
SON EISAN
TEI MOTOHIRO
description Novel cis-epoxide compounds of formula (I) are useful for treating or preventing diseases caused by HIV infection: wherein A, B, R1 to R4 and n have the same meanings as defined in the specification. The novel HIV protease inhibitor of the formula (I) has a specific structure to form a stable bonding with the enzyme active site, which entails a highly enhanced irreversible inhibition against HIV protease.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title JP2987313B
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