INTERLEUKIN-2 AGENTS AND USES THEREOF
To provide interleukin-2 agents and uses thereof.SOLUTION: IL-2 agents that comprise IL-2 variants are disclosed as well as methods, compositions, and uses thereof. The IL-2 agents described herein can be used to treat and/or prevent various disorders and conditions. Disclosed herein are IL-2 agents...
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| creator | GREGORY BABCOCK SHRIVER ZACHARY SCOTT MOORE CARLSON BOOPATHY RAMAKRISHNAN |
| description | To provide interleukin-2 agents and uses thereof.SOLUTION: IL-2 agents that comprise IL-2 variants are disclosed as well as methods, compositions, and uses thereof. The IL-2 agents described herein can be used to treat and/or prevent various disorders and conditions. Disclosed herein are IL-2 agents (e.g., IL-2 variants, IL-2 fusion proteins, IL-2 complexes, or IL-2 conjugates) that have one or more structural and/or functional properties described herein. Advantageously, several of the IL-2 agents describe herein have one or more improved or desired properties, compared to an IL-2 agent comprising a wild-type IL-2.SELECTED DRAWING: None
【課題】インターロイキン－２作用物質およびその使用を提供すること。【解決手段】ＩＬ－２バリアントを含むＩＬ－２作用物質、ならびにその方法、組成物および使用が開示される。本明細書中に記載されるＩＬ－２作用物質は、様々な障害および症状を処置および／または予防するために使用することができる。本明細書中に開示されるのは、本明細書中に記載される１またはそれより多くの構造的および／または機能的な特性を有するＩＬ－２作用物質（例えば、ＩＬ－２バリアント、ＩＬ－２融合タンパク質、ＩＬ－２複合体、またはＩＬ－２コンジュゲート）である。有利には、本明細書中に記載されるＩＬ－２作用物質のいくつかは、野生型ＩＬ－２を含むＩＬ－２作用物質と比較して、１またはそれより多くの改善された特性または所望の特性を有する。【選択図】なし |
| format | Patent |
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【課題】インターロイキン－２作用物質およびその使用を提供すること。【解決手段】ＩＬ－２バリアントを含むＩＬ－２作用物質、ならびにその方法、組成物および使用が開示される。本明細書中に記載されるＩＬ－２作用物質は、様々な障害および症状を処置および／または予防するために使用することができる。本明細書中に開示されるのは、本明細書中に記載される１またはそれより多くの構造的および／または機能的な特性を有するＩＬ－２作用物質（例えば、ＩＬ－２バリアント、ＩＬ－２融合タンパク質、ＩＬ－２複合体、またはＩＬ－２コンジュゲート）である。有利には、本明細書中に記載されるＩＬ－２作用物質のいくつかは、野生型ＩＬ－２を含むＩＬ－２作用物質と比較して、１またはそれより多くの改善された特性または所望の特性を有する。【選択図】なし</description><language>eng ; jpn</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240730&DB=EPODOC&CC=JP&NR=2024102211A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240730&DB=EPODOC&CC=JP&NR=2024102211A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GREGORY BABCOCK</creatorcontrib><creatorcontrib>SHRIVER ZACHARY</creatorcontrib><creatorcontrib>SCOTT MOORE CARLSON</creatorcontrib><creatorcontrib>BOOPATHY RAMAKRISHNAN</creatorcontrib><title>INTERLEUKIN-2 AGENTS AND USES THEREOF</title><description>To provide interleukin-2 agents and uses thereof.SOLUTION: IL-2 agents that comprise IL-2 variants are disclosed as well as methods, compositions, and uses thereof. The IL-2 agents described herein can be used to treat and/or prevent various disorders and conditions. Disclosed herein are IL-2 agents (e.g., IL-2 variants, IL-2 fusion proteins, IL-2 complexes, or IL-2 conjugates) that have one or more structural and/or functional properties described herein. Advantageously, several of the IL-2 agents describe herein have one or more improved or desired properties, compared to an IL-2 agent comprising a wild-type IL-2.SELECTED DRAWING: None
【課題】インターロイキン－２作用物質およびその使用を提供すること。【解決手段】ＩＬ－２バリアントを含むＩＬ－２作用物質、ならびにその方法、組成物および使用が開示される。本明細書中に記載されるＩＬ－２作用物質は、様々な障害および症状を処置および／または予防するために使用することができる。本明細書中に開示されるのは、本明細書中に記載される１またはそれより多くの構造的および／または機能的な特性を有するＩＬ－２作用物質（例えば、ＩＬ－２バリアント、ＩＬ－２融合タンパク質、ＩＬ－２複合体、またはＩＬ－２コンジュゲート）である。有利には、本明細書中に記載されるＩＬ－２作用物質のいくつかは、野生型ＩＬ－２を含むＩＬ－２作用物質と比較して、１またはそれより多くの改善された特性または所望の特性を有する。【選択図】なし</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFD19AtxDfJxDfX29NM1UnB0d_ULCVZw9HNRCA12DVYI8XANcvV342FgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8V4BRgZGJoYGRkaGho7GRCkCANCkI2k</recordid><startdate>20240730</startdate><enddate>20240730</enddate><creator>GREGORY BABCOCK</creator><creator>SHRIVER ZACHARY</creator><creator>SCOTT MOORE CARLSON</creator><creator>BOOPATHY RAMAKRISHNAN</creator><scope>EVB</scope></search><sort><creationdate>20240730</creationdate><title>INTERLEUKIN-2 AGENTS AND USES THEREOF</title><author>GREGORY BABCOCK ; SHRIVER ZACHARY ; SCOTT MOORE CARLSON ; BOOPATHY RAMAKRISHNAN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2024102211A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>GREGORY BABCOCK</creatorcontrib><creatorcontrib>SHRIVER ZACHARY</creatorcontrib><creatorcontrib>SCOTT MOORE CARLSON</creatorcontrib><creatorcontrib>BOOPATHY RAMAKRISHNAN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GREGORY BABCOCK</au><au>SHRIVER ZACHARY</au><au>SCOTT MOORE CARLSON</au><au>BOOPATHY RAMAKRISHNAN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>INTERLEUKIN-2 AGENTS AND USES THEREOF</title><date>2024-07-30</date><risdate>2024</risdate><abstract>To provide interleukin-2 agents and uses thereof.SOLUTION: IL-2 agents that comprise IL-2 variants are disclosed as well as methods, compositions, and uses thereof. The IL-2 agents described herein can be used to treat and/or prevent various disorders and conditions. Disclosed herein are IL-2 agents (e.g., IL-2 variants, IL-2 fusion proteins, IL-2 complexes, or IL-2 conjugates) that have one or more structural and/or functional properties described herein. Advantageously, several of the IL-2 agents describe herein have one or more improved or desired properties, compared to an IL-2 agent comprising a wild-type IL-2.SELECTED DRAWING: None
【課題】インターロイキン－２作用物質およびその使用を提供すること。【解決手段】ＩＬ－２バリアントを含むＩＬ－２作用物質、ならびにその方法、組成物および使用が開示される。本明細書中に記載されるＩＬ－２作用物質は、様々な障害および症状を処置および／または予防するために使用することができる。本明細書中に開示されるのは、本明細書中に記載される１またはそれより多くの構造的および／または機能的な特性を有するＩＬ－２作用物質（例えば、ＩＬ－２バリアント、ＩＬ－２融合タンパク質、ＩＬ－２複合体、またはＩＬ－２コンジュゲート）である。有利には、本明細書中に記載されるＩＬ－２作用物質のいくつかは、野生型ＩＬ－２を含むＩＬ－２作用物質と比較して、１またはそれより多くの改善された特性または所望の特性を有する。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | INTERLEUKIN-2 AGENTS AND USES THEREOF |
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