APTAMER-TYPE MULTI-WARHEAD COVALENT DRUG
To impart new properties that are beneficial for the function as therapeutic drugs or the like to nucleic acid aptamer-based drugs, and to provide anti-SARS-CoV-2 drugs having such new properties.SOLUTION: An aptamer-based multiwarhead covalent drug having multiple covalent warheads is provided. In...
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| creator | YANG JAY TABUCHI YUDAI TAKI MASUMI |
| description | To impart new properties that are beneficial for the function as therapeutic drugs or the like to nucleic acid aptamer-based drugs, and to provide anti-SARS-CoV-2 drugs having such new properties.SOLUTION: An aptamer-based multiwarhead covalent drug having multiple covalent warheads is provided. In particular, an aptamer-based multiwarhead covalent drug targeting SARS-CoV-2 is provided. A pharmaceutical composition comprising the multiwarhead nucleic acid aptamer and a method of producing the multiwarhead nucleic acid aptamer are also provided.SELECTED DRAWING: Figure 6
【課題】治療薬等としての機能において有用となる新しい特性を核酸アプタマー型薬剤に付与する。そのような新しい特性を有する抗ＳＡＲＳ－ＣｏＶ－２薬剤を提供する。【解決手段】複数の共有結合性ウォーヘッドを有するアプタマー型マルチウォーヘッド共有結合性薬剤を提供する。特に、ＳＡＲＳ－ＣｏＶ－２を標的とするアプタマー型マルチウォーヘッド共有結合性薬剤を提供する。マルチウォーヘッド核酸アプタマーを含む医薬組成物、およびマルチウォーヘッド核酸アプタマーの製造方法も提供される。【選択図】図６ |
| format | Patent |
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【課題】治療薬等としての機能において有用となる新しい特性を核酸アプタマー型薬剤に付与する。そのような新しい特性を有する抗ＳＡＲＳ－ＣｏＶ－２薬剤を提供する。【解決手段】複数の共有結合性ウォーヘッドを有するアプタマー型マルチウォーヘッド共有結合性薬剤を提供する。特に、ＳＡＲＳ－ＣｏＶ－２を標的とするアプタマー型マルチウォーヘッド共有結合性薬剤を提供する。マルチウォーヘッド核酸アプタマーを含む医薬組成物、およびマルチウォーヘッド核酸アプタマーの製造方法も提供される。【選択図】図６</description><language>eng ; jpn</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240724&DB=EPODOC&CC=JP&NR=2024098512A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240724&DB=EPODOC&CC=JP&NR=2024098512A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>YANG JAY</creatorcontrib><creatorcontrib>TABUCHI YUDAI</creatorcontrib><creatorcontrib>TAKI MASUMI</creatorcontrib><title>APTAMER-TYPE MULTI-WARHEAD COVALENT DRUG</title><description>To impart new properties that are beneficial for the function as therapeutic drugs or the like to nucleic acid aptamer-based drugs, and to provide anti-SARS-CoV-2 drugs having such new properties.SOLUTION: An aptamer-based multiwarhead covalent drug having multiple covalent warheads is provided. In particular, an aptamer-based multiwarhead covalent drug targeting SARS-CoV-2 is provided. A pharmaceutical composition comprising the multiwarhead nucleic acid aptamer and a method of producing the multiwarhead nucleic acid aptamer are also provided.SELECTED DRAWING: Figure 6
【課題】治療薬等としての機能において有用となる新しい特性を核酸アプタマー型薬剤に付与する。そのような新しい特性を有する抗ＳＡＲＳ－ＣｏＶ－２薬剤を提供する。【解決手段】複数の共有結合性ウォーヘッドを有するアプタマー型マルチウォーヘッド共有結合性薬剤を提供する。特に、ＳＡＲＳ－ＣｏＶ－２を標的とするアプタマー型マルチウォーヘッド共有結合性薬剤を提供する。マルチウォーヘッド核酸アプタマーを含む医薬組成物、およびマルチウォーヘッド核酸アプタマーの製造方法も提供される。【選択図】図６</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBwDAhx9HUN0g2JDHBV8A31CfHUDXcM8nB1dFFw9g9z9HH1C1FwCQp152FgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8V4BRgZGJgaWFqaGRo7GRCkCAFsDJKA</recordid><startdate>20240724</startdate><enddate>20240724</enddate><creator>YANG JAY</creator><creator>TABUCHI YUDAI</creator><creator>TAKI MASUMI</creator><scope>EVB</scope></search><sort><creationdate>20240724</creationdate><title>APTAMER-TYPE MULTI-WARHEAD COVALENT DRUG</title><author>YANG JAY ; TABUCHI YUDAI ; TAKI MASUMI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2024098512A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>YANG JAY</creatorcontrib><creatorcontrib>TABUCHI YUDAI</creatorcontrib><creatorcontrib>TAKI MASUMI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>YANG JAY</au><au>TABUCHI YUDAI</au><au>TAKI MASUMI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>APTAMER-TYPE MULTI-WARHEAD COVALENT DRUG</title><date>2024-07-24</date><risdate>2024</risdate><abstract>To impart new properties that are beneficial for the function as therapeutic drugs or the like to nucleic acid aptamer-based drugs, and to provide anti-SARS-CoV-2 drugs having such new properties.SOLUTION: An aptamer-based multiwarhead covalent drug having multiple covalent warheads is provided. In particular, an aptamer-based multiwarhead covalent drug targeting SARS-CoV-2 is provided. A pharmaceutical composition comprising the multiwarhead nucleic acid aptamer and a method of producing the multiwarhead nucleic acid aptamer are also provided.SELECTED DRAWING: Figure 6
【課題】治療薬等としての機能において有用となる新しい特性を核酸アプタマー型薬剤に付与する。そのような新しい特性を有する抗ＳＡＲＳ－ＣｏＶ－２薬剤を提供する。【解決手段】複数の共有結合性ウォーヘッドを有するアプタマー型マルチウォーヘッド共有結合性薬剤を提供する。特に、ＳＡＲＳ－ＣｏＶ－２を標的とするアプタマー型マルチウォーヘッド共有結合性薬剤を提供する。マルチウォーヘッド核酸アプタマーを含む医薬組成物、およびマルチウォーヘッド核酸アプタマーの製造方法も提供される。【選択図】図６</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | APTAMER-TYPE MULTI-WARHEAD COVALENT DRUG |
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