MACROCYCLIC KRAS INHIBITORS AND METHODS OF USE

To provide macrocyclic KRAS inhibitors and methods of use.SOLUTION: The present disclosure provides compounds useful for the inhibition of KRAS G12D, G12V, G12A, G12S, G13D, Q61H, Q61L or G12C. The compounds have the general Formula I' in the figure, where the variables in the Formula I' a...

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Hauptverfasser:	BRIAN ALAN LANMAN, RRIMALI VASUNDERA NAVARATNE, QUENTIN TERCENIO, LIPING H PETTUS, RYAN PAUL WURZ, ADRIANO BAUER, RENE RAHIMOFF, BENJAMIN WIGMAN, ALBERT AMEGADZIE, LI XIAOFEN, CHRISTOPHER MOHR, JOSE M MEDINA, JOHN CHARLES STELLWAGEN, FABIEN EMMETIERE, LI YUNXIAO, AARON C SIEGMUND, LIU QINGYIAN, SHON BOOKER, ZHAO WEI, CHEN NING, ANDREW SMALIGO, KEXUE LI, MICHAEL MASAHARU YAMANO, WU ZHICHEN
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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