4,5-ANNULATED 1,2,4-TRIAZOLONES
To provide compounds which inhibit Dihydroorotate Dehydrogenase.SOLUTION: The present invention provides 4,5-annulated 1,2,4-triazolone compounds represented by formula (I), methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and...
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| creator | MICHAEL NIEHUES SVEN CHRISTIAN MULLER THOMAS MARTINA SCHAEFER KERY LIU ANDREAS JANZER SIMON ANTHONY HERBERT JUDITH GUENTHER TIMO STELLFELD THOMAS FAUPEL STEFAN NIKOLAUS GRADL CLAUDIA MERZ ZHOU HAN JIE SHERIF EL SHEIKH JOERG KNAEBLEIN KNUT EIS ZHAO CHANGJIA STEVEN JAMES FERRARA CARL FRIEDRICH NISING DUY NGUYEN THEDE KAI KATJA ZIMMERMANN DAVID B SYKES |
| description | To provide compounds which inhibit Dihydroorotate Dehydrogenase.SOLUTION: The present invention provides 4,5-annulated 1,2,4-triazolone compounds represented by formula (I), methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds, and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.SELECTED DRAWING: None
【課題】ジヒドロオロト酸デヒドロゲナーゼを阻害する化合物を提供する。【解決手段】式（Ｉ）で表される４，５－縮環１，２，４－トリアゾロン化合物を提供する。JPEG2024063131000452.jpg54170前記化合物を調製する方法、前記化合物を調製するのに有用な中間体化合物、前記化合物を含む医薬組成物および組合せ、ならびに唯一の薬剤としてまたは他の有効成分と組み合わせて疾患、特に過剰増殖性障害を治療または予防するための医薬組成物を製造するための前記化合物の使用を提供する。【選択図】なし |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JP2024063131A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JP2024063131A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JP2024063131A3</originalsourceid><addsrcrecordid>eNrjZJA30THVdfTzC_VxDHF1UTDUMdIx0Q0J8nSM8vfx93MN5mFgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8V4BRgZGJgZmxobGho7GRCkCAMreIVo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>4,5-ANNULATED 1,2,4-TRIAZOLONES</title><source>esp@cenet</source><creator>MICHAEL NIEHUES ; SVEN CHRISTIAN ; MULLER THOMAS ; MARTINA SCHAEFER ; KERY LIU ; ANDREAS JANZER ; SIMON ANTHONY HERBERT ; JUDITH GUENTHER ; TIMO STELLFELD ; THOMAS FAUPEL ; STEFAN NIKOLAUS GRADL ; CLAUDIA MERZ ; ZHOU HAN JIE ; SHERIF EL SHEIKH ; JOERG KNAEBLEIN ; KNUT EIS ; ZHAO CHANGJIA ; STEVEN JAMES FERRARA ; CARL FRIEDRICH NISING ; DUY NGUYEN ; THEDE KAI ; KATJA ZIMMERMANN ; DAVID B SYKES</creator><creatorcontrib>MICHAEL NIEHUES ; SVEN CHRISTIAN ; MULLER THOMAS ; MARTINA SCHAEFER ; KERY LIU ; ANDREAS JANZER ; SIMON ANTHONY HERBERT ; JUDITH GUENTHER ; TIMO STELLFELD ; THOMAS FAUPEL ; STEFAN NIKOLAUS GRADL ; CLAUDIA MERZ ; ZHOU HAN JIE ; SHERIF EL SHEIKH ; JOERG KNAEBLEIN ; KNUT EIS ; ZHAO CHANGJIA ; STEVEN JAMES FERRARA ; CARL FRIEDRICH NISING ; DUY NGUYEN ; THEDE KAI ; KATJA ZIMMERMANN ; DAVID B SYKES</creatorcontrib><description>To provide compounds which inhibit Dihydroorotate Dehydrogenase.SOLUTION: The present invention provides 4,5-annulated 1,2,4-triazolone compounds represented by formula (I), methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds, and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.SELECTED DRAWING: None
【課題】ジヒドロオロト酸デヒドロゲナーゼを阻害する化合物を提供する。【解決手段】式（Ｉ）で表される４，５－縮環１，２，４－トリアゾロン化合物を提供する。JPEG2024063131000452.jpg54170前記化合物を調製する方法、前記化合物を調製するのに有用な中間体化合物、前記化合物を含む医薬組成物および組合せ、ならびに唯一の薬剤としてまたは他の有効成分と組み合わせて疾患、特に過剰増殖性障害を治療または予防するための医薬組成物を製造するための前記化合物の使用を提供する。【選択図】なし</description><language>eng ; jpn</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240510&DB=EPODOC&CC=JP&NR=2024063131A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240510&DB=EPODOC&CC=JP&NR=2024063131A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MICHAEL NIEHUES</creatorcontrib><creatorcontrib>SVEN CHRISTIAN</creatorcontrib><creatorcontrib>MULLER THOMAS</creatorcontrib><creatorcontrib>MARTINA SCHAEFER</creatorcontrib><creatorcontrib>KERY LIU</creatorcontrib><creatorcontrib>ANDREAS JANZER</creatorcontrib><creatorcontrib>SIMON ANTHONY HERBERT</creatorcontrib><creatorcontrib>JUDITH GUENTHER</creatorcontrib><creatorcontrib>TIMO STELLFELD</creatorcontrib><creatorcontrib>THOMAS FAUPEL</creatorcontrib><creatorcontrib>STEFAN NIKOLAUS GRADL</creatorcontrib><creatorcontrib>CLAUDIA MERZ</creatorcontrib><creatorcontrib>ZHOU HAN JIE</creatorcontrib><creatorcontrib>SHERIF EL SHEIKH</creatorcontrib><creatorcontrib>JOERG KNAEBLEIN</creatorcontrib><creatorcontrib>KNUT EIS</creatorcontrib><creatorcontrib>ZHAO CHANGJIA</creatorcontrib><creatorcontrib>STEVEN JAMES FERRARA</creatorcontrib><creatorcontrib>CARL FRIEDRICH NISING</creatorcontrib><creatorcontrib>DUY NGUYEN</creatorcontrib><creatorcontrib>THEDE KAI</creatorcontrib><creatorcontrib>KATJA ZIMMERMANN</creatorcontrib><creatorcontrib>DAVID B SYKES</creatorcontrib><title>4,5-ANNULATED 1,2,4-TRIAZOLONES</title><description>To provide compounds which inhibit Dihydroorotate Dehydrogenase.SOLUTION: The present invention provides 4,5-annulated 1,2,4-triazolone compounds represented by formula (I), methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds, and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.SELECTED DRAWING: None
【課題】ジヒドロオロト酸デヒドロゲナーゼを阻害する化合物を提供する。【解決手段】式（Ｉ）で表される４，５－縮環１，２，４－トリアゾロン化合物を提供する。JPEG2024063131000452.jpg54170前記化合物を調製する方法、前記化合物を調製するのに有用な中間体化合物、前記化合物を含む医薬組成物および組合せ、ならびに唯一の薬剤としてまたは他の有効成分と組み合わせて疾患、特に過剰増殖性障害を治療または予防するための医薬組成物を製造するための前記化合物の使用を提供する。【選択図】なし</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZJA30THVdfTzC_VxDHF1UTDUMdIx0Q0J8nSM8vfx93MN5mFgTUvMKU7lhdLcDEpuriHOHrqpBfnxqcUFicmpeakl8V4BRgZGJgZmxobGho7GRCkCAMreIVo</recordid><startdate>20240510</startdate><enddate>20240510</enddate><creator>MICHAEL NIEHUES</creator><creator>SVEN CHRISTIAN</creator><creator>MULLER THOMAS</creator><creator>MARTINA SCHAEFER</creator><creator>KERY LIU</creator><creator>ANDREAS JANZER</creator><creator>SIMON ANTHONY HERBERT</creator><creator>JUDITH GUENTHER</creator><creator>TIMO STELLFELD</creator><creator>THOMAS FAUPEL</creator><creator>STEFAN NIKOLAUS GRADL</creator><creator>CLAUDIA MERZ</creator><creator>ZHOU HAN JIE</creator><creator>SHERIF EL SHEIKH</creator><creator>JOERG KNAEBLEIN</creator><creator>KNUT EIS</creator><creator>ZHAO CHANGJIA</creator><creator>STEVEN JAMES FERRARA</creator><creator>CARL FRIEDRICH NISING</creator><creator>DUY NGUYEN</creator><creator>THEDE KAI</creator><creator>KATJA ZIMMERMANN</creator><creator>DAVID B SYKES</creator><scope>EVB</scope></search><sort><creationdate>20240510</creationdate><title>4,5-ANNULATED 1,2,4-TRIAZOLONES</title><author>MICHAEL NIEHUES ; SVEN CHRISTIAN ; MULLER THOMAS ; MARTINA SCHAEFER ; KERY LIU ; ANDREAS JANZER ; SIMON ANTHONY HERBERT ; JUDITH GUENTHER ; TIMO STELLFELD ; THOMAS FAUPEL ; STEFAN NIKOLAUS GRADL ; CLAUDIA MERZ ; ZHOU HAN JIE ; SHERIF EL SHEIKH ; JOERG KNAEBLEIN ; KNUT EIS ; ZHAO CHANGJIA ; STEVEN JAMES FERRARA ; CARL FRIEDRICH NISING ; DUY NGUYEN ; THEDE KAI ; KATJA ZIMMERMANN ; DAVID B SYKES</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2024063131A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>MICHAEL NIEHUES</creatorcontrib><creatorcontrib>SVEN CHRISTIAN</creatorcontrib><creatorcontrib>MULLER THOMAS</creatorcontrib><creatorcontrib>MARTINA SCHAEFER</creatorcontrib><creatorcontrib>KERY LIU</creatorcontrib><creatorcontrib>ANDREAS JANZER</creatorcontrib><creatorcontrib>SIMON ANTHONY HERBERT</creatorcontrib><creatorcontrib>JUDITH GUENTHER</creatorcontrib><creatorcontrib>TIMO STELLFELD</creatorcontrib><creatorcontrib>THOMAS FAUPEL</creatorcontrib><creatorcontrib>STEFAN NIKOLAUS GRADL</creatorcontrib><creatorcontrib>CLAUDIA MERZ</creatorcontrib><creatorcontrib>ZHOU HAN JIE</creatorcontrib><creatorcontrib>SHERIF EL SHEIKH</creatorcontrib><creatorcontrib>JOERG KNAEBLEIN</creatorcontrib><creatorcontrib>KNUT EIS</creatorcontrib><creatorcontrib>ZHAO CHANGJIA</creatorcontrib><creatorcontrib>STEVEN JAMES FERRARA</creatorcontrib><creatorcontrib>CARL FRIEDRICH NISING</creatorcontrib><creatorcontrib>DUY NGUYEN</creatorcontrib><creatorcontrib>THEDE KAI</creatorcontrib><creatorcontrib>KATJA ZIMMERMANN</creatorcontrib><creatorcontrib>DAVID B SYKES</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MICHAEL NIEHUES</au><au>SVEN CHRISTIAN</au><au>MULLER THOMAS</au><au>MARTINA SCHAEFER</au><au>KERY LIU</au><au>ANDREAS JANZER</au><au>SIMON ANTHONY HERBERT</au><au>JUDITH GUENTHER</au><au>TIMO STELLFELD</au><au>THOMAS FAUPEL</au><au>STEFAN NIKOLAUS GRADL</au><au>CLAUDIA MERZ</au><au>ZHOU HAN JIE</au><au>SHERIF EL SHEIKH</au><au>JOERG KNAEBLEIN</au><au>KNUT EIS</au><au>ZHAO CHANGJIA</au><au>STEVEN JAMES FERRARA</au><au>CARL FRIEDRICH NISING</au><au>DUY NGUYEN</au><au>THEDE KAI</au><au>KATJA ZIMMERMANN</au><au>DAVID B SYKES</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>4,5-ANNULATED 1,2,4-TRIAZOLONES</title><date>2024-05-10</date><risdate>2024</risdate><abstract>To provide compounds which inhibit Dihydroorotate Dehydrogenase.SOLUTION: The present invention provides 4,5-annulated 1,2,4-triazolone compounds represented by formula (I), methods of preparing the compounds, intermediate compounds useful for preparing the compounds, pharmaceutical compositions and combinations comprising the compounds, and the use of the compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.SELECTED DRAWING: None
【課題】ジヒドロオロト酸デヒドロゲナーゼを阻害する化合物を提供する。【解決手段】式（Ｉ）で表される４，５－縮環１，２，４－トリアゾロン化合物を提供する。JPEG2024063131000452.jpg54170前記化合物を調製する方法、前記化合物を調製するのに有用な中間体化合物、前記化合物を含む医薬組成物および組合せ、ならびに唯一の薬剤としてまたは他の有効成分と組み合わせて疾患、特に過剰増殖性障害を治療または予防するための医薬組成物を製造するための前記化合物の使用を提供する。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | 4,5-ANNULATED 1,2,4-TRIAZOLONES |
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