ALDH2 ACTIVITY-IMPROVING NUCLEIC ACID MOLECULE AND APPLICATIONS THEREOF
To provide a nucleic acid molecule that increases the proportion of wild-type ALDH2 by specifically knocking down a single nucleotide polymorphism, thereby enhancing ALDH2 activity, and to provide a pharmaceutical composition for treating ALDH2-related disease, comprising the nucleic acid molecule.S...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Patent |
| Sprache: | eng ; jpn |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | NAITO KOTA YONAMINE TAKASHI SHOYAMA YOSHINARI |
| description | To provide a nucleic acid molecule that increases the proportion of wild-type ALDH2 by specifically knocking down a single nucleotide polymorphism, thereby enhancing ALDH2 activity, and to provide a pharmaceutical composition for treating ALDH2-related disease, comprising the nucleic acid molecule.SOLUTION: A nucleic acid molecule comprises, as an expression inhibitory sequence for the mutant ALDH2 gene, a nucleotide sequence in the mutant ALDH2 gene that is complementary to a sequence of at least 15 consecutive nucleotides in a target sequence of up to 25 consecutive nucleotides within a region specified by a particular nucleotide sequence.SELECTED DRAWING: None
【課題】一塩基多型を特異的にノックダウンすることで野生型ＡＬＤＨ２の割合を増加させ、ＡＬＤＨ２の活性を向上させる核酸分子、および当該核酸分子を含む、ＡＬＤＨ２が関連する疾患の治療用の医薬組成物を提供する。【解決手段】変異型ＡＬＤＨ２遺伝子における、特定のヌクレオチド配列で示される領域中の連続する２５ヌクレオチド以下の標的配列中の、連続する１５ヌクレオチド以上のヌクレオチド配列と相補的なヌクレオチド配列を、変異型ＡＬＤＨ２遺伝子の発現抑制配列として含む、核酸分子。【選択図】なし |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_JP2024035693A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>JP2024035693A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_JP2024035693A3</originalsourceid><addsrcrecordid>eNrjZHB39HHxMFJwdA7xDPMMidT19A0I8g_z9HNX8At19nH1dAZKeboo-Pr7uDqH-rgqOPq5KDgGBPh4OjuGePr7BSuEeLgGufq78TCwpiXmFKfyQmluBiU31xBnD93Ugvz41OKCxOTUvNSSeK8AIwMjEwNjUzNLY0djohQBACeILPc</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ALDH2 ACTIVITY-IMPROVING NUCLEIC ACID MOLECULE AND APPLICATIONS THEREOF</title><source>esp@cenet</source><creator>NAITO KOTA ; YONAMINE TAKASHI ; SHOYAMA YOSHINARI</creator><creatorcontrib>NAITO KOTA ; YONAMINE TAKASHI ; SHOYAMA YOSHINARI</creatorcontrib><description>To provide a nucleic acid molecule that increases the proportion of wild-type ALDH2 by specifically knocking down a single nucleotide polymorphism, thereby enhancing ALDH2 activity, and to provide a pharmaceutical composition for treating ALDH2-related disease, comprising the nucleic acid molecule.SOLUTION: A nucleic acid molecule comprises, as an expression inhibitory sequence for the mutant ALDH2 gene, a nucleotide sequence in the mutant ALDH2 gene that is complementary to a sequence of at least 15 consecutive nucleotides in a target sequence of up to 25 consecutive nucleotides within a region specified by a particular nucleotide sequence.SELECTED DRAWING: None
【課題】一塩基多型を特異的にノックダウンすることで野生型ＡＬＤＨ２の割合を増加させ、ＡＬＤＨ２の活性を向上させる核酸分子、および当該核酸分子を含む、ＡＬＤＨ２が関連する疾患の治療用の医薬組成物を提供する。【解決手段】変異型ＡＬＤＨ２遺伝子における、特定のヌクレオチド配列で示される領域中の連続する２５ヌクレオチド以下の標的配列中の、連続する１５ヌクレオチド以上のヌクレオチド配列と相補的なヌクレオチド配列を、変異型ＡＬＤＨ２遺伝子の発現抑制配列として含む、核酸分子。【選択図】なし</description><language>eng ; jpn</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240314&DB=EPODOC&CC=JP&NR=2024035693A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240314&DB=EPODOC&CC=JP&NR=2024035693A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>NAITO KOTA</creatorcontrib><creatorcontrib>YONAMINE TAKASHI</creatorcontrib><creatorcontrib>SHOYAMA YOSHINARI</creatorcontrib><title>ALDH2 ACTIVITY-IMPROVING NUCLEIC ACID MOLECULE AND APPLICATIONS THEREOF</title><description>To provide a nucleic acid molecule that increases the proportion of wild-type ALDH2 by specifically knocking down a single nucleotide polymorphism, thereby enhancing ALDH2 activity, and to provide a pharmaceutical composition for treating ALDH2-related disease, comprising the nucleic acid molecule.SOLUTION: A nucleic acid molecule comprises, as an expression inhibitory sequence for the mutant ALDH2 gene, a nucleotide sequence in the mutant ALDH2 gene that is complementary to a sequence of at least 15 consecutive nucleotides in a target sequence of up to 25 consecutive nucleotides within a region specified by a particular nucleotide sequence.SELECTED DRAWING: None
【課題】一塩基多型を特異的にノックダウンすることで野生型ＡＬＤＨ２の割合を増加させ、ＡＬＤＨ２の活性を向上させる核酸分子、および当該核酸分子を含む、ＡＬＤＨ２が関連する疾患の治療用の医薬組成物を提供する。【解決手段】変異型ＡＬＤＨ２遺伝子における、特定のヌクレオチド配列で示される領域中の連続する２５ヌクレオチド以下の標的配列中の、連続する１５ヌクレオチド以上のヌクレオチド配列と相補的なヌクレオチド配列を、変異型ＡＬＤＨ２遺伝子の発現抑制配列として含む、核酸分子。【選択図】なし</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZHB39HHxMFJwdA7xDPMMidT19A0I8g_z9HNX8At19nH1dAZKeboo-Pr7uDqH-rgqOPq5KDgGBPh4OjuGePr7BSuEeLgGufq78TCwpiXmFKfyQmluBiU31xBnD93Ugvz41OKCxOTUvNSSeK8AIwMjEwNjUzNLY0djohQBACeILPc</recordid><startdate>20240314</startdate><enddate>20240314</enddate><creator>NAITO KOTA</creator><creator>YONAMINE TAKASHI</creator><creator>SHOYAMA YOSHINARI</creator><scope>EVB</scope></search><sort><creationdate>20240314</creationdate><title>ALDH2 ACTIVITY-IMPROVING NUCLEIC ACID MOLECULE AND APPLICATIONS THEREOF</title><author>NAITO KOTA ; YONAMINE TAKASHI ; SHOYAMA YOSHINARI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2024035693A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>NAITO KOTA</creatorcontrib><creatorcontrib>YONAMINE TAKASHI</creatorcontrib><creatorcontrib>SHOYAMA YOSHINARI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>NAITO KOTA</au><au>YONAMINE TAKASHI</au><au>SHOYAMA YOSHINARI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ALDH2 ACTIVITY-IMPROVING NUCLEIC ACID MOLECULE AND APPLICATIONS THEREOF</title><date>2024-03-14</date><risdate>2024</risdate><abstract>To provide a nucleic acid molecule that increases the proportion of wild-type ALDH2 by specifically knocking down a single nucleotide polymorphism, thereby enhancing ALDH2 activity, and to provide a pharmaceutical composition for treating ALDH2-related disease, comprising the nucleic acid molecule.SOLUTION: A nucleic acid molecule comprises, as an expression inhibitory sequence for the mutant ALDH2 gene, a nucleotide sequence in the mutant ALDH2 gene that is complementary to a sequence of at least 15 consecutive nucleotides in a target sequence of up to 25 consecutive nucleotides within a region specified by a particular nucleotide sequence.SELECTED DRAWING: None
【課題】一塩基多型を特異的にノックダウンすることで野生型ＡＬＤＨ２の割合を増加させ、ＡＬＤＨ２の活性を向上させる核酸分子、および当該核酸分子を含む、ＡＬＤＨ２が関連する疾患の治療用の医薬組成物を提供する。【解決手段】変異型ＡＬＤＨ２遺伝子における、特定のヌクレオチド配列で示される領域中の連続する２５ヌクレオチド以下の標的配列中の、連続する１５ヌクレオチド以上のヌクレオチド配列と相補的なヌクレオチド配列を、変異型ＡＬＤＨ２遺伝子の発現抑制配列として含む、核酸分子。【選択図】なし</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng ; jpn |
| recordid | cdi_epo_espacenet_JP2024035693A |
| source | esp@cenet |
| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | ALDH2 ACTIVITY-IMPROVING NUCLEIC ACID MOLECULE AND APPLICATIONS THEREOF |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-21T17%3A47%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=NAITO%20KOTA&rft.date=2024-03-14&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EJP2024035693A%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |