ORAL DISPERSIBLE VACCINE COMPRISING VIROSOMES

To provide oral vaccine dosage forms and processes for producing oral vaccine formulations.SOLUTION: An oral solid vaccine formulation comprises: lipid-based vesicles comprising an immunogenic amount of at least one target molecule; at least one cryo-lyoprotectant comprising a polyol, a sucrose, an...

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Hauptverfasser: MARIO AMACKER, SYLVAIN FLEURY, CHARLI SMARDON, ANTONIUS JOHANNES HENRIKUS STEGMANN, WONG YIK TENG, KHOJASTEH SHIRKHANI
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creator MARIO AMACKER
SYLVAIN FLEURY
CHARLI SMARDON
ANTONIUS JOHANNES HENRIKUS STEGMANN
WONG YIK TENG
KHOJASTEH SHIRKHANI
description To provide oral vaccine dosage forms and processes for producing oral vaccine formulations.SOLUTION: An oral solid vaccine formulation comprises: lipid-based vesicles comprising an immunogenic amount of at least one target molecule; at least one cryo-lyoprotectant comprising a polyol, a sucrose, an amino acid, an oligosaccharide, or a combination thereof; a matrix former comprising gelatin, starch or a combination thereof; and a structure former comprising mannitol, dextrose, lactose, galactose, cyclodextrin or a combination thereof.SELECTED DRAWING: None 【課題】 経口ワクチン剤形及び経口ワクチン製剤を産生するための方法を提供すること。【解決手段】 免疫原性量の少なくとも1つの標的分子を含む脂質ベースの小胞;ポリオール、ショ糖、アミノ酸、オリゴ糖、又はそれらの組合せを含む、少なくとも1つのクライオ-リオプロテクタント;ゼラチン、デンプン又はそれらの組合せを含む、マトリックス形成剤;及びマンニトール、デキストロース、ラクトース、ガラクトース、シクロデキストリン又はそれらの組合せを含む、構造形成剤を含む経口固形ワクチン製剤により、上記課題を解決する。【選択図】なし
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ORAL DISPERSIBLE VACCINE COMPRISING VIROSOMES
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