METHODS, COMPOSITIONS, AND IMPLANTABLE ELEMENTS COMPRISING ACTIVE CELLS

To provide an implantable element comprising an engineered active cell, and a pharmaceutical composition comprising the element.SOLUTION: The present invention provides an engineered active cell, or an implantable element comprising the engineered active cell, wherein the engineered active cell is an engineered retinal pigment epithelial (RPE) cell or an engineered cell derived from an RPE cell, and wherein the engineered active cell comprises an exogenous nucleic acid encoding a polypeptide, wherein the exogenous nucleic acid comprises one or more selected from a specific group of nucleotide sequences.SELECTED DRAWING: None 【課題】組み換え活性細胞を含む移植可能な要素、前記要素を含む医薬組成物を提供する。【解決手段】組み換え活性細胞、又は前記組み換え活性細胞を含む移植可能な要素であって、前記組み換え活性細胞が、組み換え網膜色素上皮（ＲＰＥ）細胞又はＲＰＥ細胞に由来する組み換え細胞であり、前記組み換え活性細胞が、ポリペプチドをコードする外因性の核酸を含み、前記外因性の核酸が、特定のヌクレオチド配列群のうちの１つ以上を含む、組み換え活性細胞又は組み換え活性細胞を含む移植可能な要素である。【選択図】なし