MATERIALS AND METHODS FOR TREATMENT OF PAIN-RELATED DISORDERS

To provide safe and effective treatments involving SCN9A-related indications.SOLUTION: The present application provides materials and methods for treating a patient having one or more conditions associated with SCN9A regardless of being ex vivo or in vivo. In addition, the present application provid...

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Hauptverfasser:	ANTE SVEN LUNDBERG, LAWRENCE KLEIN, HARI KUMAR PADMANABHAN, SAMARTH KULKARNI
Format:	Patent
Sprache:	eng ; jpn
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	To provide safe and effective treatments involving SCN9A-related indications.SOLUTION: The present application provides materials and methods for treating a patient having one or more conditions associated with SCN9A regardless of being ex vivo or in vivo. In addition, the present application provides materials and methods for editing and/or modulating the expression of the SCN9A gene in a cell by genome editing.SELECTED DRAWING: Figure 1 【課題】ＳＣＮ９Ａ関連適応症に関する安全で有効な処置を提供すること。【解決手段】本出願は、ｅｘｖｉｖｏまたはｉｎｖｉｖｏに関わらずＳＣＮ９Ａと関連する１つまたは複数の状態を有する患者を処置するための物質及び方法を提供する。加えて、本出願は、ゲノム編集によって細胞内でＳＣＮ９Ａ遺伝子の発現を編集及び／またはモジュレートするための物質及び方法を提供する。【選択図】図１