METHODS OF INACTIVATING VIRAL CONTAMINANTS
To provide a method for preparing an antibody-containing solution free from viral contaminants starting from cultured cells.SOLUTION: Provided is a method for preparing a virus-inactivated antibody solution, comprising (i) harvesting antibody material produced by transfected cells comprising the cod...
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| creator | FILIPA ABRANTES LAURE CAHUZAC LIONEL DUARTE SONIA LETESTU |
| description | To provide a method for preparing an antibody-containing solution free from viral contaminants starting from cultured cells.SOLUTION: Provided is a method for preparing a virus-inactivated antibody solution, comprising (i) harvesting antibody material produced by transfected cells comprising the coding sequences of the antibody, which have undergone cell culture; (ii) subjecting a virus inactivation treatment for the collected antibody material, the virus inactivation treatment being incubation with a mixture of a solvent and a detergent, and the harvested antibody material being a clarified harvest produced in non-human mammalian cells and comprising a monoclonal recombinant antibody that is multispecific.SELECTED DRAWING: Figure 1
【課題】培養細胞から開始するウイルス汚染物質を含まない抗体含有溶液を作製する方法を提供する。【解決手段】ウイルス不活性化抗体溶液を作製するための方法であって、（ｉ）細胞培養を経た、抗体のコード配列を含むトランスフェクトされた細胞によって産生された前記抗体材料を採取する工程、（ｉｉ）前記採取された抗体材料に対するウイルス不活性化処理の工程であって、前記ウイルス不活性化処理が、溶媒及び洗浄剤の混合物とのインキュベーションであり、ならびに、前記採取された抗体材料が、非ヒト哺乳動物細胞で産生される、清澄化された採取物であり、かつ多重特異性であるモノクローナル組換え抗体を含む、前記工程、を含む、方法を提供する。【選択図】図１ |
| format | Patent |
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【課題】培養細胞から開始するウイルス汚染物質を含まない抗体含有溶液を作製する方法を提供する。【解決手段】ウイルス不活性化抗体溶液を作製するための方法であって、（ｉ）細胞培養を経た、抗体のコード配列を含むトランスフェクトされた細胞によって産生された前記抗体材料を採取する工程、（ｉｉ）前記採取された抗体材料に対するウイルス不活性化処理の工程であって、前記ウイルス不活性化処理が、溶媒及び洗浄剤の混合物とのインキュベーションであり、ならびに、前記採取された抗体材料が、非ヒト哺乳動物細胞で産生される、清澄化された採取物であり、かつ多重特異性であるモノクローナル組換え抗体を含む、前記工程、を含む、方法を提供する。【選択図】図１</description><language>eng ; jpn</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240109&DB=EPODOC&CC=JP&NR=2024001035A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240109&DB=EPODOC&CC=JP&NR=2024001035A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>FILIPA ABRANTES</creatorcontrib><creatorcontrib>LAURE CAHUZAC</creatorcontrib><creatorcontrib>LIONEL DUARTE</creatorcontrib><creatorcontrib>SONIA LETESTU</creatorcontrib><title>METHODS OF INACTIVATING VIRAL CONTAMINANTS</title><description>To provide a method for preparing an antibody-containing solution free from viral contaminants starting from cultured cells.SOLUTION: Provided is a method for preparing a virus-inactivated antibody solution, comprising (i) harvesting antibody material produced by transfected cells comprising the coding sequences of the antibody, which have undergone cell culture; (ii) subjecting a virus inactivation treatment for the collected antibody material, the virus inactivation treatment being incubation with a mixture of a solvent and a detergent, and the harvested antibody material being a clarified harvest produced in non-human mammalian cells and comprising a monoclonal recombinant antibody that is multispecific.SELECTED DRAWING: Figure 1
【課題】培養細胞から開始するウイルス汚染物質を含まない抗体含有溶液を作製する方法を提供する。【解決手段】ウイルス不活性化抗体溶液を作製するための方法であって、（ｉ）細胞培養を経た、抗体のコード配列を含むトランスフェクトされた細胞によって産生された前記抗体材料を採取する工程、（ｉｉ）前記採取された抗体材料に対するウイルス不活性化処理の工程であって、前記ウイルス不活性化処理が、溶媒及び洗浄剤の混合物とのインキュベーションであり、ならびに、前記採取された抗体材料が、非ヒト哺乳動物細胞で産生される、清澄化された採取物であり、かつ多重特異性であるモノクローナル組換え抗体を含む、前記工程、を含む、方法を提供する。【選択図】図１</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNDydQ3x8HcJVvB3U_D0c3QO8QxzDPH0c1cI8wxy9FFw9vcLcfQFSviFBPMwsKYl5hSn8kJpbgYlN9cQZw_d1IL8-NTigsTk1LzUknivACMDIxMDA0MDY1NHY6IUAQCjyCUe</recordid><startdate>20240109</startdate><enddate>20240109</enddate><creator>FILIPA ABRANTES</creator><creator>LAURE CAHUZAC</creator><creator>LIONEL DUARTE</creator><creator>SONIA LETESTU</creator><scope>EVB</scope></search><sort><creationdate>20240109</creationdate><title>METHODS OF INACTIVATING VIRAL CONTAMINANTS</title><author>FILIPA ABRANTES ; LAURE CAHUZAC ; LIONEL DUARTE ; SONIA LETESTU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_JP2024001035A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; jpn</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>FILIPA ABRANTES</creatorcontrib><creatorcontrib>LAURE CAHUZAC</creatorcontrib><creatorcontrib>LIONEL DUARTE</creatorcontrib><creatorcontrib>SONIA LETESTU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>FILIPA ABRANTES</au><au>LAURE CAHUZAC</au><au>LIONEL DUARTE</au><au>SONIA LETESTU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>METHODS OF INACTIVATING VIRAL CONTAMINANTS</title><date>2024-01-09</date><risdate>2024</risdate><abstract>To provide a method for preparing an antibody-containing solution free from viral contaminants starting from cultured cells.SOLUTION: Provided is a method for preparing a virus-inactivated antibody solution, comprising (i) harvesting antibody material produced by transfected cells comprising the coding sequences of the antibody, which have undergone cell culture; (ii) subjecting a virus inactivation treatment for the collected antibody material, the virus inactivation treatment being incubation with a mixture of a solvent and a detergent, and the harvested antibody material being a clarified harvest produced in non-human mammalian cells and comprising a monoclonal recombinant antibody that is multispecific.SELECTED DRAWING: Figure 1
【課題】培養細胞から開始するウイルス汚染物質を含まない抗体含有溶液を作製する方法を提供する。【解決手段】ウイルス不活性化抗体溶液を作製するための方法であって、（ｉ）細胞培養を経た、抗体のコード配列を含むトランスフェクトされた細胞によって産生された前記抗体材料を採取する工程、（ｉｉ）前記採取された抗体材料に対するウイルス不活性化処理の工程であって、前記ウイルス不活性化処理が、溶媒及び洗浄剤の混合物とのインキュベーションであり、ならびに、前記採取された抗体材料が、非ヒト哺乳動物細胞で産生される、清澄化された採取物であり、かつ多重特異性であるモノクローナル組換え抗体を含む、前記工程、を含む、方法を提供する。【選択図】図１</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPIRITS VINEGAR WINE |
| title | METHODS OF INACTIVATING VIRAL CONTAMINANTS |
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