GIP/GLP1 CO-AGONIST COMPOUNDS

To provide compounds that have agonist activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors and are suitable for oral administration.SOLUTION: The present invention provides a compound having a specific amino acid sequence or a p...

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Hauptverfasser: QU HONGCHANG, JORGE ALSINA-FERNANDEZ, FRANCIS STAFFORD WILLARD, JAMES LINCOLN WALLIS, COSKUN TAMER, OVER CABRERA, ROBERT CHADWICK CUMMINS, AKTHAM ABURUB, KYLE WYNN SLOOP, ROBERT ANDREW BROWN, MOHAMED ELSAYED HAMED ELSAYED, MILATA MARY ABRAHAM, PHENIL JAYANTILAL PATEL, THI THANH HUYEN TRAN, AMITA DATTA-MANNAN, LAI XIANYIN
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creator QU HONGCHANG
JORGE ALSINA-FERNANDEZ
FRANCIS STAFFORD WILLARD
JAMES LINCOLN WALLIS
COSKUN TAMER
OVER CABRERA
ROBERT CHADWICK CUMMINS
AKTHAM ABURUB
KYLE WYNN SLOOP
ROBERT ANDREW BROWN
MOHAMED ELSAYED HAMED ELSAYED
MILATA MARY ABRAHAM
PHENIL JAYANTILAL PATEL
THI THANH HUYEN TRAN
AMITA DATTA-MANNAN
LAI XIANYIN
description To provide compounds that have agonist activity at both the human glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors and are suitable for oral administration.SOLUTION: The present invention provides a compound having a specific amino acid sequence or a pharmaceutically acceptable salt thereof.SELECTED DRAWING: None 【課題】ヒトグルコース依存性インスリン分泌刺激ポリペプチド(GIP)受容体およびグルカゴン様ペプチド-1(GLP-1)受容体でアゴニスト活性を有する、経口投与に適した化合物を提供する。【解決手段】特定のアミノ酸配列を有する化合物、またはその薬学的に許容可能な塩による。【選択図】なし
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subjects BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
SPIRITS
VINEGAR
WINE
title GIP/GLP1 CO-AGONIST COMPOUNDS
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